Reactome | PPIA [cytosol]

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PPIA

Stable Identifier

R-HSA-173123

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CypA protein

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Calcineurin activates NFAT (Homo sapiens)
        
        Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
        
        Cyclophilin A:Cyclosporin A [cytosol] (Homo sapiens)
        
        PPIA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62937 PPIA

Gene Names

PPIA, CYPA

Chain

initiator methionine:1, chain:1-165, chain:2-165

Reference Genes

BioGPS Gene:5478 PPIA

COSMIC (genes):PPIA PPIA

CTD Gene:5478 PPIA

dbSNP Gene:5478 PPIA

ENSEMBL:ENSG00000196262 PPIA

HGNC:9253 PPIA

KEGG Gene (Homo sapiens):hsa:5478 PPIA

Monarch:5478 PPIA

NCBI Gene:5478 PPIA

OMIM:123840 PPIA

UCSC:P62937 PPIA

Reference Transcript

Other Identifiers

0002690706

11725710_a_at

11725711_x_at

11725712_s_at

11752928_x_at

11758017_x_at

11758067_x_at

1AK4

1AWQ

1AWR

1AWS

1AWT

1AWU

1AWV

1BCK

1CWA

1CWB

1CWC

1CWF

1CWH

1CWI

1CWJ

1CWK

1CWL

1CWM

1CWO

1FGL

1M63

1M9C

1M9D

1M9E

1M9F

1M9X

1M9Y

1MF8

1MIK

1NMK

1OCA

1RMH

1VBS

1VBT

1W8L

1W8M

1W8V

1YND

1ZKF

201293_3p_x_at

201293_x_at

211378_3p_x_at

211378_x_at

211765_3p_x_at

211765_x_at

211978_3p_x_at

211978_x_at

212661_3p_x_at

212661_x_at

226336_at

2567594

2567597

2675551

2898671

2898673

2898675

2949035

2949036

2ALF

2CPL

2CYH

2MS4

2MZU

2N0T

2RMA

2RMB

2X25

2X2A

2X2C

2X2D

2XGY

3000075

3000080

3000081

3000083

3000085

3000087

3000091

3000092

3000093

3000094

3000095

3000096

3062970

3295264

33667_at

3374006

3569637

3602437

3915708

3CYH

3CYS

3K0M

3K0N

3K0O

3K0P

3K0Q

3K0R

3ODI

3ODL

3RDD

4655

4CYH

4IPZ

4N1M

4N1N

4N1O

4N1P

4N1Q

4N1R

4N1S

4YUG

4YUH

4YUI

4YUJ

4YUK

4YUL

4YUM

4YUN

4YUO

4YUP

5478

58345

5CYH

5F66

5FJB

5KUL

5KUN

5KUO

5KUQ

5KUR

5KUS

5KUU

5KUV

5KUW

5KUZ

5KV0

5KV1

5KV2

5KV3

5KV4

5KV5

5KV6

5KV7

5LUD

5T9U

5T9W

5T9Z

5TA2

5TA4

7919436

8067978

8132642

A_23_P258340

A_24_P920125

A_24_P95038

A_32_P68459

CAB004655

CCDS5494

CCDS75592

ENSG00000196262

ENSP00000419425

ENSP00000427976

ENSP00000430817

ENSP00000479961

ENST00000355968

ENST00000468812

ENST00000489459

ENST00000620047

EntrezGene:5478

g10863926_3p_s_at

g12654762_3p_s_at

g13543665_3p_s_at

GE79899

GO:0000413

GO:0003723

GO:0003755

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005925

GO:0006278

GO:0006457

GO:0016018

GO:0016020

GO:0016032

GO:0016853

GO:0019058

GO:0019061

GO:0019064

GO:0019068

GO:0019076

GO:0030260

GO:0031982

GO:0034389

GO:0034774

GO:0035722

GO:0043312

GO:0045069

GO:0045070

GO:0046790

GO:0050714

GO:0050900

GO:0051082

GO:0070062

GO:0075713

GO:1904813

HGNC:9253

HPA058345

Hs.182937.2.S1_3p_s_at

Hs.182937.3.A1_3p_at

Hs.267690.2.S1_3p_s_at

Hs.356331

ILMN_1704529

MIM:123840

NM_001300981

NM_021130

NP_001287910

NP_066953

PF00160

PH_hs_0032846

PPIA

PPIA-201

PPIA-204

PPIA-208

PPIA-210

PR00153

uc003tlw.4

uc064djo.1

uc064djp.1

uc064djq.1

UPI000003AF82

UPI0000072F14

V9HWF5

X52851_rna1_at

Participant Of

input

Packaging of HIV virion on the host cell plasma membrane

hasMember

Platelet releasate (inferred) cytosolic proteins [cytosol]

hasComponent

output

Formation of Pre-Integration Complex (PIC)

Other forms of this molecule

PPIA [extracellular exosome]

PPIA [secretory granule lumen]

PPIA [extracellular region]

PPIA [ficolin-1-rich granule lumen]

Cross References

RefSeq

NP_066953.1, NP_001287910.1

Brenda

5.2.1.8

ZINC - Substances

PPIA_HUMAN

GeneCards

P62937

DOCK Blaster

4YUN, 3ODL, 5CYH, 1M9C, 5T9U, 5T9Z, 1CWH, 1CWL, 5KUO, 5KUW, 1MIK, 5T9W, 1M9Y, 3CYH, 5KV5, 3K0O, 5KUZ, 1AWT, 2X2C, 2ALF, 3K0P, 2X2A, 5TA2, 1W8M, 5KUV, 4YUI, 5KUL, 4N1N, 5KV6, 2XGY, 4N1O, 4YUK, 1RMH, 1BCK, 1M9D, 4YUO, 1CWK, 5LUD, 1VBS, 2X2D, 2RMA, 5KV4, 2X25, 3K0N, 1AWU, 1AWQ, 5KV3, 1CWM, 4YUJ, 5KUU, 1YND, 5KUN, 1CWC, 1M9E, 4YUL, 4N1Q, 2CPL, 5F66, 3RDD, 1CWF, 1CWJ, 3ODI, 4IPZ, 5KV1, 1W8V, 1FGL, 3K0R, 2RMB, 3K0M, 1ZKF, 5KUS, 2CYH, 1AWV, 1AWR, 5KV2, 5KUR, 4N1S, 5TA4, 4N1M, 1CWB, 4YUM, 1M9F, 4CYH, 4N1P, 1M63, 4YUG, 1AK4, 1CWI, 5KV0, 1VBT, 1MF8, 1M9X, 1AWS, 5KUQ, 3K0Q, 1CWO, 1W8L, 4YUP, 4N1R, 5KV7, 1NMK, 4YUH, 1CWA

ZINC target

P62937

PRO

P62937

ZINC - Predictions - Purchasable

PPIA_HUMAN

HMDB Protein

HMDBP10691

PDB

5KUZ, 3K0R, 1M9C, 1CWJ, 5KUW, 5NOV, 5KV5, 5KV4, 5FJB, 1VBT, 1W8L, 4YUG, 1W8M, 5T9U, 4N1P, 1M9E, 5NOS, 1CWO, 1OCA, 2MZU, 1VBS, 3K0N, 4YUJ, 5KUR, 3CYS, 5NOQ, 2X2C, 1MIK, 5KV6, 5NOX, 3ODL, 5T9Z, 1CWK, 5CYH, 3K0Q, 2XGY, 4N1R, 1M9Y, 1AWQ, 1CWM, 5KUO, 5NOU, 2ALF, 3K0P, 5KUN, 4CYH, 1AWT, 5NOR, 1CWA, 4YUL, 1CWH, 1ZKF, 1M9D, 1M9X, 1M63, 4N1S, 5KV1, 4YUI, 1AK4, 5LUD, 1FGL, 1CWI, 5NOW, 2CPL, 1AWS, 5F66, 4YUO, 1AWR, 4YUP, 5KUU, 4N1M, 3ODI, 1CWL, 4IPZ, 4N1Q, 1CWC, 2CYH, 1AWU, 2MS4, 2N0T, 4YUN, 5KV2, 3K0M, 5NOZ, 4YUH, 5KUQ, 5KV7, 5T9W, 1W8V, 4N1N, 3RDD, 2X2A, 1RMH, 2RMB, 5KUV, 2X25, 5NOT, 3K0O, 1M9F, 3CYH, 5KV3, 1AWV, 5KUS, 4YUM, 1CWB, 1NMK, 5TA4, 2RMA, 5KUL, 1YND, 1MF8, 2X2D, 5TA2, 1BCK, 4YUK, 5KV0, 4N1O, 1CWF, 5NOY

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q72497 Q72497			0.623	7
UniProt:P46108-1 CRK			0.611	4
UniProt:Q99IB8-PRO_0000045602			0.59	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q16849 PTPRN			0.508	3
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.508	2
UniProt:O95831 AIFM1			0.463	2