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Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
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Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
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PPIA [cytosol]
Stable Identifier
R-HSA-173123
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CypA protein
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Annealing of 3'-end of unwound transfer RNA primer with genomic RNA (Homo sapiens)
RTC (Reverse Transcription Complex) with RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Binding and entry of HIV virion (Homo sapiens)
Fusion of viral membrane with host cell membrane (Homo sapiens)
Viral core surrounded by Matrix layer [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Formation of RTC (Reverse Transcription Complex) (Homo sapiens)
RTC (Reverse Transcription Complex) with RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
uncoated viral complex [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Integration of provirus (Homo sapiens)
Formation of Pre-Integration Complex (PIC) (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [cytosol] (Homo sapiens)
RTC with integration competent viral DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)
RTC with integration competent viral DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [cytosol] (Homo sapiens)
RTC with integration competent viral DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)
RTC with duplex DNA containing discontinuous plus strand flap [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with integration competent viral DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Reverse Transcription of HIV RNA (Homo sapiens)
Minus-strand DNA synthesis (Homo sapiens)
First strand transfer mediated by Repeated (R) sequence (Homo sapiens)
RTC with degraded RNA template and minus sssDNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with minus sssDNA transferred to 3'-end of viral RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Minus strand DNA synthesis resumes (Homo sapiens)
RTC with minus sssDNA transferred to 3'-end of viral RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with minus strand DNA synthesis initiated from 3'-end [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with nicked minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RNase H-mediated cleavage of the template strand (Homo sapiens)
RTC with extensive RNase-H digestion [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with minus strand DNA synthesis initiated from 3'-end [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)
RTC with degraded RNA template and minus sssDNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with nicked minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RNase H-mediated degradation of the template strand (Homo sapiens)
RTC with extending minus strand DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with extensive RNase-H digestion [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Plus-strand DNA synthesis (Homo sapiens)
3' PPT-primed initiation of plus-strand DNA synthesis (Homo sapiens)
RTC with extending minus strand DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with extending second-strand DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers (Homo sapiens)
RTC with extending second-strand DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC without viral RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Second strand transfer by annealing complementary PBS sequences (Homo sapiens)
RTC with annealed complementary PBS seqments in +sssDNA and -strand DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC without viral RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Synthesis of full-length duplex viral DNA with a discontinuous plus strand (Homo sapiens)
RTC with annealed complementary PBS seqments in +sssDNA and -strand DNA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with duplex DNA containing discontinuous plus strand flap [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Uncoating of the HIV Virion (Homo sapiens)
Disassembly of viral capsid (Homo sapiens)
Encapsidated viral core [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
uncoated viral complex [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Disintegration of matrix layer (Homo sapiens)
Encapsidated viral core [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Viral core surrounded by Matrix layer [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Assembly Of The HIV Virion (Homo sapiens)
Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)
Assembling HIV virion [plasma membrane] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Assembling HIV virion [plasma membrane] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
APOBEC3G mediated resistance to HIV-1 infection (Homo sapiens)
Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand (Homo sapiens)
APOBEC3G:RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)
APOBEC3G:RTC with deaminated minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
RTC with minus sssDNA containing deaminated C residues:tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
APOBEC3G:RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of (inferred) platelet cytosolic components (Homo sapiens)
Platelet releasate (inferred) cytosolic proteins [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
Cyclophilin A:Cyclosporin A [cytosol] (Homo sapiens)
PPIA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62937 PPIA
Gene Names
PPIA, CYPA
Chain
initiator methionine:1, chain:1-165, chain:2-165
Reference Genes
BioGPS Gene:5478 PPIA
COSMIC (genes):PPIA PPIA
CTD Gene:5478 PPIA
dbSNP Gene:5478 PPIA
ENSEMBL:ENSG00000196262 PPIA
ENSEMBL_homo_sapiens_GENE:ENSG00000196262 PPIA
HGNC:9253 PPIA
KEGG Gene (Homo sapiens):5478 PPIA
Monarch:5478 PPIA
NCBI Gene:5478 PPIA
OMIM:123840 PPIA
UCSC:P62937 PPIA
Reference Transcript
RefSeq:NM_001300981.1 PPIA
RefSeq:NM_021130.4 PPIA
Other Identifiers
0002690706
11725710_a_at
11725711_x_at
11725712_s_at
11752928_x_at
11758017_x_at
11758067_x_at
1AK4
1AWQ
1AWR
1AWS
1AWT
1AWU
1AWV
1BCK
1CWA
1CWB
1CWC
1CWF
1CWH
1CWI
1CWJ
1CWK
1CWL
1CWM
1CWO
1FGL
1M63
1M9C
1M9D
1M9E
1M9F
1M9X
1M9Y
1MF8
1MIK
1NMK
1OCA
1RMH
1VBS
1VBT
1W8L
1W8M
1W8V
1YND
1ZKF
201293_3p_x_at
201293_x_at
211378_3p_x_at
211378_x_at
211765_3p_x_at
211765_x_at
211978_3p_x_at
211978_x_at
212661_3p_x_at
212661_x_at
226336_at
2567594
2567597
2675551
2898671
2898673
2898675
2949035
2949036
2ALF
2CPL
2CYH
2MS4
2MZU
2N0T
2RMA
2RMB
2X25
2X2A
2X2C
2X2D
2XGY
3000075
3000080
3000081
3000083
3000085
3000087
3000091
3000092
3000093
3000094
3000095
3000096
3062970
3295264
33667_at
3374006
3569637
3602437
3915708
3CYH
3CYS
3K0M
3K0N
3K0O
3K0P
3K0Q
3K0R
3ODI
3ODL
3RDD
4655
4CYH
4IPZ
4N1M
4N1N
4N1O
4N1P
4N1Q
4N1R
4N1S
4YUG
4YUH
4YUI
4YUJ
4YUK
4YUL
4YUM
4YUN
4YUO
4YUP
5478
58345
5CYH
5F66
5FJB
5KUL
5KUN
5KUO
5KUQ
5KUR
5KUS
5KUU
5KUV
5KUW
5KUZ
5KV0
5KV1
5KV2
5KV3
5KV4
5KV5
5KV6
5KV7
5LUD
5NOQ
5NOR
5NOS
5NOT
5NOU
5NOV
5NOW
5NOX
5NOY
5NOZ
5T9U
5T9W
5T9Z
5TA2
5TA4
5WC7
6BTA
7919436
8067978
8132642
A_23_P258340
A_24_P920125
A_24_P95038
A_32_P68459
AAH00689
AAH03026
AAH05320
AAH05982
AAH07104
AAH13915
AAH73992
AAH93076
AAI06031
AAI37058
AAI37059
AAU13906
AB451307
AB451438
AC004854
AC013436
ACJ13704
AK290085
AK293003
AY739283
BAF82774
BAF85692
BAG70121
BAG70252
BC000689
BC003026
BC005320
BC005982
BC007104
BC013915
BC073992
BC093076
BC106030
BC137057
BC137058
C9J5S7
CAA37039
CAA68264
CAB004655
CAG32988
CCDS5494
CCDS75592
CR456707
E5RIZ5
ENSG00000196262
ENSP00000419425
ENSP00000427976
ENSP00000430817
ENSP00000479961
ENST00000355968
ENST00000468812
ENST00000489459
ENST00000620047
EntrezGene:5478
EU794650
F8WE65
g10863926_3p_s_at
g12654762_3p_s_at
g13543665_3p_s_at
GE79899
GO:0000413
GO:0002376
GO:0003674
GO:0003723
GO:0003755
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005925
GO:0006259
GO:0006278
GO:0006457
GO:0006464
GO:0006810
GO:0007165
GO:0008150
GO:0009058
GO:0016018
GO:0016020
GO:0016032
GO:0016192
GO:0016853
GO:0019058
GO:0019061
GO:0019064
GO:0019068
GO:0019076
GO:0022607
GO:0030260
GO:0031410
GO:0031982
GO:0032991
GO:0034389
GO:0034641
GO:0034774
GO:0035722
GO:0040011
GO:0043226
GO:0043312
GO:0044403
GO:0045069
GO:0045070
GO:0046790
GO:0048870
GO:0050714
GO:0050900
GO:0051082
GO:0061024
GO:0070062
GO:0075713
GO:1904813
HGNC:9253
HPA058345
Hs.182937.2.S1_3p_s_at
Hs.182937.3.A1_3p_at
Hs.267690.2.S1_3p_s_at
ILMN_1704529
IPR002130
IPR020892
IPR024936
IPR029000
MIM:123840
NM_001300981
NM_021130
NP_001287910
NP_066953
PF00160
PH_hs_0032846
PPIA
PPIA-201
PPIA-204
PPIA-208
PPIA-210
PR00153
uc003tlw.4
uc064djo.1
uc064djp.1
uc064djq.1
UPI000003AF82
UPI0000072F14
V9HWF5
X52851
X52851_rna1_at
XM_024446809
XP_024302577
Y00052
Participant Of
hasMember
Platelet releasate (inferred) cytosolic proteins [cytosol]
input
Packaging of HIV virion on the host cell plasma membrane
output
Formation of Pre-Integration Complex (PIC)
hasComponent
Assembling HIV virion [plasma membrane]
Cyclophilin A:Cyclosporin A [cytosol]
Encapsidated viral core [cytosol]
RTC (Reverse Transcription Complex) with RNA template [cytosol]
RTC with annealed complementary PBS seqments in +sssDNA and -strand DNA [cytosol]
RTC with degraded RNA template and minus sssDNA [cytosol]
RTC with duplex DNA containing discontinuous plus strand flap [cytosol]
RTC with extending minus strand DNA [cytosol]
RTC with extending second-strand DNA [cytosol]
RTC with extensive RNase-H digestion [cytosol]
RTC with integration competent viral DNA [cytosol]
RTC with minus sssDNA containing deaminated C residues:tRNA primer:RNA template [cytosol]
RTC with minus sssDNA transferred to 3'-end of viral RNA template [cytosol]
RTC with minus sssDNA:tRNA primer:RNA template [cytosol]
RTC with minus strand DNA synthesis initiated from 3'-end [cytosol]
RTC with nicked minus sssDNA:tRNA primer:RNA template [cytosol]
RTC with tRNA primer:RNA template [cytosol]
RTC without viral RNA template [cytosol]
uncoated viral complex [cytosol]
Viral core surrounded by Matrix layer [cytosol]
Other forms of this molecule
PPIA [extracellular exosome]
PPIA [secretory granule lumen]
PPIA [ficolin-1-rich granule lumen]
PPIA [extracellular region]
Cross References
RefSeq
NP_001287910.1
,
NP_066953.1
OpenTargets
ENSG00000196262
ZINC - Substances
PPIA_HUMAN
GeneCards
P62937
DOCK Blaster
4N1S
,
1W8M
,
2CYH
,
4N1M
,
5TA4
,
1BCK
,
5KUQ
,
1M9E
,
5KV1
,
1CWH
,
1CWL
,
4N1Q
,
2X25
,
3K0Q
,
2X2D
,
5T9W
,
5KUS
,
1AWQ
,
1AWU
,
1VBT
,
4YUJ
,
4YUN
,
1RMH
,
2XGY
,
1NMK
,
3ODI
,
5CYH
,
1M9F
,
5KUZ
,
5KV0
,
1CWK
,
5KV5
,
4N1P
,
5T9U
,
4N1R
,
3K0P
,
1CWM
,
5T9Z
,
1MF8
,
3K0O
,
1AK4
,
5KV7
,
1M9X
,
1AWR
,
1AWV
,
1CWC
,
4YUK
,
4YUO
,
3RDD
,
2RMA
,
5TA2
,
4N1N
,
5KV3
,
1ZKF
,
5KUW
,
5KUO
,
1CWF
,
1CWJ
,
1M9C
,
4IPZ
,
1YND
,
5KV6
,
1MIK
,
5LUD
,
3K0N
,
5KUL
,
5KUV
,
4YUH
,
1M9Y
,
1VBS
,
1AWS
,
1CWB
,
2ALF
,
4YUL
,
2RMB
,
1W8L
,
3ODL
,
1FGL
,
5KV2
,
4CYH
,
4N1O
,
1CWI
,
1M9D
,
1M63
,
5KUR
,
5F66
,
5KUN
,
3CYH
,
1CWO
,
2X2A
,
2X2C
,
5KV4
,
3K0M
,
1W8V
,
4YUP
,
3K0R
,
5KUU
,
2CPL
,
4YUI
,
1AWT
,
1CWA
,
4YUM
,
4YUG
ZINC target
P62937
PRO
P62937
BRENDA (Homo sapiens)
5.2.1.8
ZINC - Predictions - Purchasable
PPIA_HUMAN
HMDB Protein
HMDBP10691
PDB
5KUU
,
5NOT
,
5KUS
,
5T9W
,
4N1R
,
4N1S
,
5NOW
,
1CWH
,
5TA4
,
1W8V
,
5T9U
,
1CWI
,
1FGL
,
5LUD
,
4YUG
,
5F66
,
5KUZ
,
1RMH
,
5NOX
,
2X25
,
1ZKF
,
5KV0
,
3CYH
,
1CWL
,
5KV3
,
1M9C
,
1CWM
,
5CYH
,
4YUH
,
1YND
,
5FJB
,
3CYS
,
4YUK
,
1BCK
,
1AWQ
,
1M9F
,
5KV4
,
4IPZ
,
5KV7
,
3K0O
,
5KUL
,
4CYH
,
2X2D
,
1MIK
,
4YUL
,
4N1M
,
1MF8
,
5NOQ
,
1M9X
,
2CPL
,
1AWT
,
4YUO
,
1AWU
,
3K0P
,
5TA2
,
2RMA
,
1VBT
,
5KUR
,
1VBS
,
5NOR
,
4N1P
,
5KUQ
,
4N1Q
,
4YUP
,
2CYH
,
5WC7
,
5NOU
,
1W8L
,
1CWC
,
1CWF
,
1W8M
,
5KUW
,
1NMK
,
5KUV
,
5NOV
,
5KV1
,
5NOY
,
1CWJ
,
3RDD
,
1CWK
,
6BTA
,
1OCA
,
4YUI
,
1AK4
,
5T9Z
,
1M9D
,
2MS4
,
2MZU
,
5NOZ
,
5KV2
,
1CWO
,
2X2C
,
5KV5
,
3K0M
,
1M63
,
1M9E
,
2X2A
,
4YUJ
,
4YUM
,
2ALF
,
1AWR
,
3K0N
,
1AWS
,
5KV6
,
3ODL
,
3K0Q
,
5KUO
,
3ODI
,
5KUN
,
1M9Y
,
4N1N
,
4YUN
,
4N1O
,
5NOS
,
1CWA
,
2RMB
,
1CWB
,
2N0T
,
1AWV
,
3K0R
,
2XGY
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q72497 Q72497
0.623
7
UniProt:P46108-1 CRK
0.611
4
UniProt:Q99IB8-PRO_0000045602
0.59
2
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:O00429 DNM1L
2
DNM1L [cytosol]
(R-HSA-351943)
DNM1L [mitochondrial outer membrane]
(R-HSA-351942)
0.527
5
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.508
2
UniProt:Q16849 PTPRN
0.508
3
UniProt:Q96D03 DDT4L
0.488
2
UniProt:O95831 AIFM1
0.463
2
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