Reactome | PPIA [cytosol]

PPIA [cytosol]

Stable Identifier

R-HSA-173123

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CypA protein

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Calcineurin activates NFAT (Homo sapiens)
        
        Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
        
        Cyclophilin A:Cyclosporin A [cytosol] (Homo sapiens)
        
        PPIA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62937 PPIA

Gene Names

PPIA, CYPA

Chain

initiator methionine:1, chain:1-165, chain:2-165

Reference Genes

BioGPS Gene:5478 PPIA

COSMIC (genes):PPIA PPIA

CTD Gene:5478 PPIA

dbSNP Gene:5478 PPIA

ENSEMBL:ENSG00000196262 PPIA

HGNC:9253 PPIA

KEGG Gene (Homo sapiens):5478 PPIA

Monarch:5478 PPIA

NCBI Gene:5478 PPIA

OMIM:123840 PPIA

UCSC:P62937 PPIA

Reference Transcript

Other Identifiers

0002690706

11725710_a_at

11725711_x_at

11725712_s_at

11752928_x_at

11758017_x_at

11758067_x_at

201293_3p_x_at

201293_x_at

211378_3p_x_at

211378_x_at

211765_3p_x_at

211765_x_at

211978_3p_x_at

211978_x_at

212661_3p_x_at

212661_x_at

226336_at

2567594

2567597

2675551

2898671

2898673

2898675

2949035

2949036

3000074

3000075

3000080

3000081

3000083

3000085

3000087

3000091

3000092

3000093

3000094

3000095

3000096

3000097

3062970

3295264

33667_at

3374006

3569637

3602437

3915708

5478

7919436

8067978

8132642

A_23_P258340

A_24_P920125

A_24_P95038

A_32_P68459

GE79899

GO:0000187

GO:0000413

GO:0001933

GO:0001934

GO:0002376

GO:0003674

GO:0003723

GO:0003755

GO:0005178

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005925

GO:0006259

GO:0006278

GO:0006457

GO:0006464

GO:0006469

GO:0006810

GO:0006915

GO:0006950

GO:0007155

GO:0007165

GO:0008150

GO:0008219

GO:0009058

GO:0015031

GO:0016018

GO:0016020

GO:0016032

GO:0016192

GO:0016853

GO:0019058

GO:0019061

GO:0019064

GO:0019068

GO:0019076

GO:0030154

GO:0030168

GO:0030182

GO:0030593

GO:0030595

GO:0031410

GO:0031982

GO:0032148

GO:0032873

GO:0032991

GO:0034389

GO:0034599

GO:0034641

GO:0034774

GO:0035307

GO:0035722

GO:0040011

GO:0042118

GO:0043167

GO:0043226

GO:0043231

GO:0043312

GO:0044403

GO:0044409

GO:0045069

GO:0045070

GO:0046790

GO:0048856

GO:0048870

GO:0050714

GO:0050900

GO:0051082

GO:0051092

GO:0060352

GO:0061024

GO:0061944

GO:0070062

GO:0070527

GO:0075713

GO:1902176

GO:1903901

GO:1904399

GO:1904813

GO:2001233

HMNXSV003009370

HMNXSV003058305

Hs.182937.2.S1_3p_s_at

Hs.182937.3.A1_3p_at

Hs.267690.2.S1_3p_s_at

ILMN_1704529

PH_hs_0032846

X52851_rna1_at

g10863926_3p_s_at

g12654762_3p_s_at

g13543665_3p_s_at

Participates

as a member of

Platelet releasate (inferred) cytosolic proteins [cytosol] (Homo sapiens)

as a component of

as an input of

Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)

as an output of

Formation of Pre-Integration Complex (PIC) (Homo sapiens)

Other forms of this molecule

PPIA [extracellular exosome]

PPIA [ficolin-1-rich granule lumen]

PPIA [extracellular region]

PPIA [secretory granule lumen]

Cross References

RefSeq

NP_066953.1, NP_001287910.1

Guide to Pharmacology - Targets

2751

OpenTargets

ENSG00000196262

ZINC - Substances

PPIA_HUMAN

ZINC target

P62937

PRO

P62937

GlyGen

P62937

PDB

2CYH, 2RMB, 5NOS, 5KUS, 3CYS, 6Y9Z, 2N0T, 1FGL, 1CWJ, 6GJN, 1AWT, 4YUK, 5NOU, 2RMA, 5KUU, 1AWQ, 5LUD, 3K0P, 3CYH, 5KV6, 1M9F, 4N1N, 6GJI, 5KUN, 6Y9W, 1CWM, 4YUN, 6X3R, 3RDD, 4N1O, 2X2D, 4YUG, 5KUZ, 5NOY, 1M9C, 6U5D, 5KUO, 4YUH, 6GJJ, 1YND, 1M9Y, 4N1R, 2XGY, 5KV3, 6X4M, 5KV4, 2X25, 6BTA, 1OCA, 4N1S, 6X4O, 6GJR, 4YUM, 5NOW, 6GS6, 5KV7, 1CWF, 3K0O, 5T9U, 5KV0, 1CWC, 6Y9X, 1W8L, 2X2A, 2MS4, 1AWU, 6X4P, 1CWK, 5KUR, 5TA2, 5NOR, 1VBS, 1AWS, 4YUJ, 6U5E, 6GJM, 1CWI, 1NMK, 1MIK, 5TA4, 2CPL, 1W8V, 1CWH, 1AWR, 5WC7, 6ZDJ, 5NOV, 6Y9V, 3ODI, 1BCK, 5KUL, 5KUW, 1M63, 3K0Q, 1CWO, 4YUO, 5NOQ, 4N1P, 5KUQ, 2X2C, 1M9D, 3K0M, 3K0R, 4YUP, 6I42, 5NOZ, 1M9X, 6GJL, 1MF8, 4YUI, 4N1Q, 1VBT, 1RMH, 1ZKF, 6GJP, 5NOT, 5KV5, 6X4N, 4CYH, 6U5G, 4YUL, 4IPZ, 5KUV, 4N1M, 5T9W, 1M9E, 2ALF, 3K0N, 5NOX, 3ODL, 5FJB, 6X3Y, 1W8M, 5T9Z, 5KV1, 6Y9Y, 1CWB, 5KV2, 6U5C, 1CWA, 5F66, 5CYH, 6GJY, 1AWV, 2MZU, 1AK4, 6X4Q, 1CWL

GeneCards

P62937

HPA

ENSG00000196262-PPIA

Ensembl

ENST00000468812, ENSP00000427976, ENSG00000196262, ENST00000620047, ENSP00000479961, ENSP00000419425, ENST00000355968, ENST00000489459, ENSP00000430817

Pharos - Targets

P62937

ZINC - Predictions - Purchasable

PPIA_HUMAN

HMDB Protein

HMDBP10691

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59595 N	9	SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063) N [plasma membrane] (R-COV-9683611) N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478)	0.676	4
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	4
UniProt:Q72497 Q72497			0.623	7
UniProt:P46108-1 CRK			0.595	4
UniProt:Q99IB8-PRO_0000045602			0.59	2
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.589	2
UniProt:Q00535 CDK5	4	p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.556	3
UniProt:P62841 RPS15	2	RPS15 [cytosol] (R-HSA-72335) RPS15 [nucleoplasm] (R-HSA-6798706)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.556	3
UniProt:O43614 HCRTR2	1	HCRTR2 [plasma membrane] (R-HSA-389421)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:O00429 DNM1L	2	DNM1L [cytosol] (R-HSA-351943) DNM1L [mitochondrial outer membrane] (R-HSA-351942)	0.527	5
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.508	2
UniProt:Q16849 PTPRN			0.508	3
UniProt:P0C6X7-PRO_0000037309 REP			0.508	4
UniProt:O95831 AIFM1			0.463	2