CTNNB1 S45F [cytosol]

Stable Identifier
R-HSA-4791268
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Catenin beta-1, CTNB1_HUMAN
Icon
CTNNB1 S45F [cytosol] icon
CTNNB1 S45F [cytosol] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
10367940 Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis

Miyoshi, Y, Iwao, K, Nawa, G, Yoshikawa, H, Ochi, T, Nakamura, Y

Oncol. Res. 1998
9065402 Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Morin, PJ, Sparks, AB, Korinek, V, Barker, N, Clevers, HC, Vogelstein, B, Kinzler, KW

Science 1997
11746989 Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability

Shimizu, Y, Ikeda, S, Fujimori, M, Kodama, S, Nakahara, M, Okajima, M, Asahara, T

Genes Chromosomes Cancer 2002
17204608 An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

Rivera, MN, Kim, WJ, Wells, J, Driscoll, DR, Brannigan, BW, Han, M, Kim, JC, Feinberg, AP, Gerald, WL, Vargas, SO, Chin, L, Iafrate, AJ, Bell, DW, Haber, DA

Science 2007
External Reference Information
External Reference
UniProt:P35222 CTNNB1
Gene Names
CTNNB1, CTNNB, OK/SW-cl.35, PRO2286
Chain
initiator methionine:1, chain:2-781
Reference Genes
BioGPS Gene:1499 CTNNB1
COSMIC (genes):CTNNB1 CTNNB1
CTD Gene:1499 CTNNB1
dbSNP Gene:1499 CTNNB1
ENSEMBL:ENSG00000168036 CTNNB1
ENSEMBL_homo_sapiens_GENE:ENSG00000168036 CTNNB1
HGNC:2514 CTNNB1
KEGG Gene (Homo sapiens):1499 CTNNB1
Monarch:1499 CTNNB1
NCBI Gene:1499 CTNNB1
OMIM:116806 CTNNB1
UCSC:P35222 CTNNB1
Reference Transcript
Other Identifiers
0001990132
108
11722167_s_at
11747387_a_at
11747388_x_at
11748951_a_at
11748952_x_at
11749021_s_at
11749022_x_at
11750680_x_at
1499
1554411_at
16939558
1950
1G3J
1JDH
1JPW
1LUJ
1P22
1QZ7
1T08
1TH1
201533_at
2618941
2618942
2618945
2618946
2618955
2618957
2618958
2618959
2618960
2618961
2618962
2618965
2618967
2618969
2618971
2618973
2618975
2618978
2618980
2618981
2618982
2618983
29159
29160
2G57
2GL7
2Z6H
3DIW
3FQN
3FQR
3SL9
3SLA
3TX7
40777_at
4DJS
8079021
A0A024R2Q3
A0A2R8Y543
A0A2R8Y5A3
A0A2R8Y5C3
A0A2R8Y5Z1
A0A2R8Y750
A0A2R8Y7Z0
A0A2R8Y804
A0A2R8Y815
A0A2R8YCH5
A_14_P106050
A_14_P131897
A_23_P29495
A_23_P29499
A_33_P3421695
AAG35511
AAH58926
AAL89457
AAR18817
AB062292
AC104307
AF130085
AK289932
AY081165
AY463360
BAB93475
BAF82621
BC058926
C9IZ65
C9JV16
CAA61107
CAA79497
CAB000108
CAB001950
CCDS2694
CH471055
CTNNB1
CTNNB1-201
CTNNB1-202
CTNNB1-203
CTNNB1-204
CTNNB1-206
CTNNB1-207
CTNNB1-208
CTNNB1-209
CTNNB1-216
CTNNB1-217
CTNNB1-218
CTNNB1-222
CTNNB1-223
CTNNB1-225
CTNNB1-226
CTNNB1-228
CTNNB1-229
CTNNB1-235
CTNNB1-238
CTNNB1-241
CTNNB1-246
CTNNB1-250
CTNNB1-252
CTNNB1-255
E7EMJ5
E7EV28
E9PDF9
EAW64625
EAW64626
EAW64627
EAW64628
ENSG00000168036
ENSP00000344456
ENSP00000379486
ENSP00000379488
ENSP00000385604
ENSP00000387455
ENSP00000401599
ENSP00000409302
ENSP00000412219
ENSP00000493533
ENSP00000493610
ENSP00000494053
ENSP00000494411
ENSP00000494677
ENSP00000494845
ENSP00000494914
ENSP00000495076
ENSP00000495244
ENSP00000495360
ENSP00000495450
ENSP00000495719
ENSP00000495992
ENSP00000496021
ENSP00000496180
ENSP00000496385
ENST00000349496
ENST00000396183
ENST00000396185
ENST00000405570
ENST00000431914
ENST00000433400
ENST00000441708
ENST00000450969
ENST00000642248
ENST00000642315
ENST00000642426
ENST00000642992
ENST00000643031
ENST00000643297
ENST00000643541
ENST00000643977
ENST00000643992
ENST00000644867
ENST00000645210
ENST00000645320
ENST00000645982
ENST00000646369
ENST00000646725
ENST00000647390
EntrezGene:1499
g4503130_3p_at
GE60116
GO:0000003
GO:0000122
GO:0000228
GO:0000278
GO:0000578
GO:0000902
GO:0000904
GO:0000922
GO:0000988
GO:0001085
GO:0001102
GO:0001501
GO:0001569
GO:0001570
GO:0001658
GO:0001701
GO:0001702
GO:0001706
GO:0001708
GO:0001709
GO:0001711
GO:0001764
GO:0001822
GO:0001837
GO:0001840
GO:0001944
GO:0002052
GO:0002053
GO:0002089
GO:0002376
GO:0003266
GO:0003338
GO:0003340
GO:0003674
GO:0003682
GO:0003700
GO:0003713
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005719
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0005913
GO:0005916
GO:0005923
GO:0005925
GO:0005938
GO:0006259
GO:0006355
GO:0006357
GO:0006464
GO:0006790
GO:0006810
GO:0006950
GO:0007010
GO:0007049
GO:0007059
GO:0007155
GO:0007160
GO:0007165
GO:0007223
GO:0007267
GO:0007268
GO:0007398
GO:0007399
GO:0007403
GO:0007507
GO:0008022
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009058
GO:0009790
GO:0009948
GO:0009950
GO:0009953
GO:0009954
GO:0009987
GO:0010468
GO:0010628
GO:0010629
GO:0010718
GO:0010909
GO:0014704
GO:0016020
GO:0016032
GO:0016055
GO:0016192
GO:0016323
GO:0016328
GO:0016331
GO:0016342
GO:0016525
GO:0016600
GO:0019827
GO:0019899
GO:0019900
GO:0019901
GO:0019903
GO:0021700
GO:0021819
GO:0022009
GO:0022405
GO:0022607
GO:0030018
GO:0030027
GO:0030054
GO:0030097
GO:0030154
GO:0030182
GO:0030217
GO:0030316
GO:0030324
GO:0030331
GO:0030521
GO:0030539
GO:0030856
GO:0030858
GO:0030877
GO:0030900
GO:0030901
GO:0030902
GO:0030997
GO:0031016
GO:0031069
GO:0031253
GO:0031528
GO:0031641
GO:0032212
GO:0032331
GO:0032355
GO:0032481
GO:0032991
GO:0032993
GO:0033077
GO:0033234
GO:0034330
GO:0034332
GO:0034333
GO:0034394
GO:0034613
GO:0034641
GO:0034750
GO:0035050
GO:0035112
GO:0035115
GO:0035116
GO:0035257
GO:0035315
GO:0035635
GO:0036023
GO:0040007
GO:0040011
GO:0042127
GO:0042129
GO:0042475
GO:0042493
GO:0042592
GO:0042733
GO:0042981
GO:0042995
GO:0043065
GO:0043066
GO:0043123
GO:0043226
GO:0043296
GO:0043410
GO:0043525
GO:0043588
GO:0044281
GO:0044325
GO:0044334
GO:0044336
GO:0044403
GO:0044798
GO:0045177
GO:0045202
GO:0045294
GO:0045296
GO:0045453
GO:0045595
GO:0045596
GO:0045603
GO:0045667
GO:0045669
GO:0045670
GO:0045671
GO:0045743
GO:0045765
GO:0045892
GO:0045893
GO:0045944
GO:0045976
GO:0046332
GO:0046982
GO:0048096
GO:0048145
GO:0048469
GO:0048471
GO:0048489
GO:0048513
GO:0048538
GO:0048599
GO:0048617
GO:0048643
GO:0048646
GO:0048660
GO:0048715
GO:0048856
GO:0048870
GO:0050681
GO:0050767
GO:0050768
GO:0050808
GO:0051091
GO:0051145
GO:0051149
GO:0051276
GO:0051571
GO:0051884
GO:0051973
GO:0060066
GO:0060070
GO:0060173
GO:0060439
GO:0060440
GO:0060441
GO:0060479
GO:0060484
GO:0060492
GO:0060742
GO:0060769
GO:0060789
GO:0060828
GO:0060916
GO:0061047
GO:0061154
GO:0061198
GO:0061324
GO:0061549
GO:0061550
GO:0065003
GO:0070062
GO:0070369
GO:0070411
GO:0070491
GO:0070602
GO:0071363
GO:0071681
GO:0071944
GO:0072001
GO:0072033
GO:0072053
GO:0072054
GO:0072079
GO:0072182
GO:0090279
GO:0097718
GO:0098609
GO:1901215
GO:1903204
GO:1904501
GO:1904793
GO:1904796
GO:1904798
GO:1904837
GO:1904886
GO:1904888
GO:1904948
GO:1904954
GO:1990138
GO:1990403
GO:1990791
GO:1990907
GO:1990909
GO:2000008
GO:2000017
GO:2000144
GO:2000179
GO:2001234
HGNC:2514
HPA029159
HPA029160
Hs2.171271.2.S1_3p_s_at
ILMN_1651617
ILMN_1746396
ILMN_1757350
IPR000225
IPR011989
IPR013284
IPR016024
MIM:114500
MIM:114550
MIM:116806
MIM:132600
MIM:155255
MIM:167000
MIM:615075
MIM:617572
NM_001098209
NM_001098210
NM_001904
NP_001091679
NP_001091680
NP_001895
PF00514
PH_hs_0024820
PR01869
SM00185
TC03000214.hg
uc003ckp.3
uc003ckq.3
uc003ckr.3
uc010hia.2
UPI000012862F
X87838
X87838_at
XM_005264886
XM_017005738
XM_024453357
XM_024453358
XP_005264943
XP_016861227
XP_024309124
XP_024309125
XP_024309126
Z19054
Participant Of
hasCandidate
Other forms of this molecule
CTNNB1 S45P [cytosol]
pT41,S45-CTNNB1 S37F [cytosol]
pT41,S45-CTNNB1 S37A [cytosol]
pT41,S45-CTNNB1 S37C [cytosol]
pS37,T41,S45-CTNNB1 S33C [cytosol]
pS37,T41,S45-CTNNB1 S33F [cytosol]
pS37,T41,S45-CTNNB1 S33P [cytosol]
pS37,T41,S45-CTNNB1 S33Y [cytosol]
pS45-CTNNB1 T41A [cytosol]
pS45-CTNNB1 T41I [cytosol]
Ub-K,p-Y-CTNNB1 [cytosol]
p-Y-CTNNB1 [cytosol]
p-S552-CTNNB1 [nucleoplasm]
p-S552-CTNNB1 [cytosol]
CTNNB1(116-376) [cytosol]
CTNNB1(1-115) [cytosol]
CTNNB1 [plasma membrane]
p-S45 CTNNB1 [cytosol]
p-T41,S45 CTNNB1 [cytosol]
p-S37,T41,S45, CTNNB1 [cytosol]
p-S33,S37,T41,S45 CTNNB1 [cytosol]
CTNNB1 [cytosol]
CTNNB1 [nucleoplasm]
Modified Residues
Name
L-serine 45 replaced with L-phenylalanine
Coordinate
45
PsiMod
L-serine removal [MOD:01646]
A protein modification that effectively removes or replaces an L-serine.
L-phenylalanine residue [MOD:00023]
A protein modification that effectively converts a source amino acid residue to L-phenylalanine.
Disease
Name Identifier Synonyms
adrenal gland cancer 3953 malignant neoplasm of adrenal gland, adrenal cancer, malignant neoplasm of adrenal gland NOS (disorder), adrenal neoplasm, neoplasm of adrenal gland (disorder), malignant tumor of adrenal gland (disorder), tumor of the Adrenal gland, malignant Adrenal tumor
endometrial cancer 1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
colorectal cancer 9256
hepatocellular carcinoma 684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
cancer 162 malignant tumor, malignant neoplasm, primary cancer
kidney cancer 263 malignant neoplasm of kidney except pelvis, malignant tumour of kidney, renal cancer
connective tissue cancer 201 connective tissue neoplasm, neoplasm of connective tissues (disorder), Tumour of connective tissue
Cross References
RefSeq
COSMIC
OpenTargets
GeneCards
ZINC - Substances
DOCK Blaster
ZINC target
PRO
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
PDB
Interactors (85)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9NQB0 TCF7L2  4 0.967 25
 UniProt:P12830 CDH1  10 0.951 15
 UniProt:P49841 GSK3B  4 0.95 19
 UniProt:P25054 APC  13 0.949 17
 UniProt:P15884 TCF4  1 0.94 22
 UniProt:O15169 AXIN1  11 0.94 44
 UniProt:Q9Y297 BTRC  2 0.926 8
 UniProt:Q9NSA3 CTNNBIP1  1 0.917 12
 UniProt:P10275 AR  4 0.891 15
 UniProt:P19022 CDH2  3 0.887 8
 UniProt:P46937 YAP1  7 0.881 14
 UniProt:Q9UJU2 LEF1  2 0.858 9
 UniProt:P33151 CDH5  2 0.815 6
 UniProt:P36402 TCF7  1 0.779 4
 UniProt:P35221 CTNNA1  2 0.758 4
 UniProt:Q9UKB1 FBXW11  1 0.723 4
 UniProt:Q6P1J9 CDC73  1 0.714 10
 UniProt:P63208 SKP1  2 0.713 3
 UniProt:Q5JTC6 AMER1  3 0.711 9
 UniProt:O43707 ACTN4  3 0.696 7
 UniProt:O35625 Axin1  3 0.688 4
 UniProt:Q96AC1 FERMT2  1 0.681 13
 UniProt:Q08050 FOXM1  3 0.672 16
 UniProt:P14923 JUP  5 0.669 3
 UniProt:P19838 NFKB1  8 0.667 3
 UniProt:Q01826 SATB1  5 0.66 9
 UniProt:Q13761 RUNX3  7 0.656 12
 UniProt:P55197 AF10      0.656 5
 UniProt:O00482-1 NR5A2  1 0.65 5
 UniProt:Q9GZV5 WWTR1  3 0.641 4
 UniProt:P26358 DNMT1  2 0.628 8
 UniProt:Q9YGY0 AXIN1      0.609 2
 UniProt:P08575 PTPRC  2 0.609 2
 UniProt:P23470 PTPRG      0.609 2
 UniProt:Q12913 PTPRJ  2 0.609 2
 UniProt:Q9GZQ8 MAP1LC3B  3 0.602 5
 UniProt:P49023 PXN  4 0.602 4
 UniProt:P49789 FHIT      0.602 4
 UniProt:P18012 IPAC      0.602 4
 UniProt:P50402 EMD  1 0.591 3
 UniProt:Q8TEW0 PARD3  3 0.589 2
 UniProt:Q04206 RELA  6 0.589 3
 UniProt:P11362 FGFR1  8 0.589 2
 UniProt:Q13308 PTK7      0.581 5
 UniProt:Q9BZE0 GLIS2      0.581 6
 UniProt:Q13625 TP53BP2  1 0.576 5
 IntAct:EBI-4399559 UBIQ      0.576 3
 UniProt:O75564 JERKY      0.576 3
 UniProt:Q92793 CREBBP  3 0.573 2
 UniProt:P33724  5 0.571 5
 UniProt:P11388 TOP2A  3 0.57 5
 UniProt:P16284 PECAM1  4 0.564 3
 UniProt:Q99697 PITX2  1 0.564 2
 UniProt:Q8TEK3 DOT1L  1 0.564 3
 UniProt:Q9Y2T1 AXIN2  4 0.564 2
 UniProt:P00519 ABL1  5 0.544 2
 UniProt:P12931 SRC  6 0.544 2
 UniProt:Q03431 PTH1R  1 0.543 4
 UniProt:Q9NYF0 DACT1  1 0.537 3
 IntAct:EBI-5237192 AXIN2      0.527 2
 UniProt:P09803 Cdh1  1 0.527 3
 UniProt:Q9EPK5 Wwtr1  4 0.525 2
 UniProt:Q9UKE5 TNIK  1 0.525 3
 UniProt:P02511 CRYAB  1 0.524 3
 UniProt:A1Z199 A1Z199      0.524 2
 UniProt:P14618-1 PKM  1 0.524 3
 UniProt:Q9JHQ5  1 0.524 2
 UniProt:P14618 PKM  3 0.524 4
 UniProt:O14746 TERT  1 0.524 2
 UniProt:P29474 NOS3  7 0.524 4
 UniProt:Q15599 NHRF2      0.508 2
 UniProt:O00512 BCL9  1 0.508 2
 UniProt:P08069 IGF1R  3 0.499 3
 IntAct:EBI-6668710 TCF      0.499 3
 UniProt:P18146 EGR1  1 0.499 7
 UniProt:Q9H6I2 SOX17  1 0.499 2
 UniProt:Q9Y265 RUVBL1  1 0.499 3
 UniProt:Q92597 NDRG1  1 0.499 3
 UniProt:P49757 NUMB  1 0.499 2
 UniProt:Q14160 SCRIB  1 0.463 2
 UniProt:P46940 IQGAP1  3 0.463 3
 UniProt:Q14526 HIC1  2 0.463 2
 UniProt:O95071 UBR5      0.463 6
 UniProt:P11279 LAMP1  3 0.462 2
 UniProt:Q99593 TBX5  1 0.462 3