CTNNB1 S45F [cytosol]

Stable Identifier
R-HSA-4791268
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Catenin beta-1, CTNB1_HUMAN
Icon
CTNNB1 S45F [cytosol] icon
CTNNB1 S45F [cytosol] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
9065402 Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Barker, N, Clevers, HC, Morin, PJ, Kinzler, KW, Vogelstein, B, Korinek, V, Sparks, AB

Science 1997
10367940 Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis

Nawa, G, Ochi, T, Nakamura, Y, Miyoshi, Y, Yoshikawa, H, Iwao, K

Oncol. Res. 1998
11746989 Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability

Kodama, S, Fujimori, M, Ikeda, S, Nakahara, M, Okajima, M, Asahara, T, Shimizu, Y

Genes Chromosomes Cancer 2002
17204608 An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

Iafrate, AJ, Wells, J, Rivera, MN, Chin, L, Han, M, Vargas, SO, Haber, DA, Bell, DW, Brannigan, BW, Gerald, WL, Kim, JC, Feinberg, AP, Kim, WJ, Driscoll, DR

Science 2007
External Reference Information
External Reference
UniProt:P35222 CTNNB1
Gene Names
CTNNB1, CTNNB, OK/SW-cl.35, PRO2286
Chain
initiator methionine:1, chain:2-781
Reference Genes
BioGPS Gene:1499 CTNNB1
COSMIC (genes):CTNNB1 CTNNB1
CTD Gene:1499 CTNNB1
dbSNP Gene:1499 CTNNB1
ENSEMBL:ENSG00000168036.18 CTNNB1
HGNC:2514 CTNNB1
KEGG Gene (Homo sapiens):1499 CTNNB1
Monarch:1499 CTNNB1
NCBI Gene:1499 CTNNB1
OMIM:116806 CTNNB1
UCSC:P35222 CTNNB1
Reference Transcript
Other Identifiers
0001990132
11722167_s_at
11747387_a_at
11747388_x_at
11748951_a_at
11748952_x_at
11749021_s_at
11749022_x_at
11750680_x_at
1499
1554411_PM_at
1554411_at
16939558
201533_PM_at
201533_at
2618941
2618942
2618945
2618946
2618952
2618953
2618955
2618957
2618958
2618959
2618960
2618961
2618962
2618965
2618967
2618969
2618971
2618973
2618975
2618978
2618980
2618981
2618982
2618983
40777_at
8079021
A_14_P106050
A_14_P131897
A_23_P29495
A_23_P29499
A_33_P3421695
GE60116
GE752547
GO:0000122
GO:0000165
GO:0000209
GO:0000278
GO:0000578
GO:0000791
GO:0000904
GO:0000922
GO:0001221
GO:0001501
GO:0001569
GO:0001570
GO:0001649
GO:0001658
GO:0001701
GO:0001702
GO:0001706
GO:0001708
GO:0001711
GO:0001764
GO:0001822
GO:0001837
GO:0001840
GO:0001894
GO:0001944
GO:0002052
GO:0002053
GO:0002062
GO:0002067
GO:0002089
GO:0002376
GO:0003266
GO:0003338
GO:0003340
GO:0003682
GO:0003713
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0005916
GO:0005923
GO:0005925
GO:0005938
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007010
GO:0007059
GO:0007155
GO:0007160
GO:0007249
GO:0007268
GO:0007398
GO:0007399
GO:0007403
GO:0007405
GO:0007507
GO:0008013
GO:0008022
GO:0008104
GO:0008283
GO:0008284
GO:0008285
GO:0008543
GO:0009410
GO:0009948
GO:0009950
GO:0009953
GO:0009954
GO:0010463
GO:0010468
GO:0010628
GO:0010629
GO:0010718
GO:0010909
GO:0012501
GO:0014704
GO:0016020
GO:0016055
GO:0016192
GO:0016323
GO:0016327
GO:0016328
GO:0016331
GO:0016342
GO:0016525
GO:0016600
GO:0016922
GO:0019827
GO:0019899
GO:0019900
GO:0019901
GO:0019903
GO:0021819
GO:0021854
GO:0022009
GO:0022405
GO:0022414
GO:0023052
GO:0030018
GO:0030027
GO:0030054
GO:0030097
GO:0030154
GO:0030163
GO:0030182
GO:0030217
GO:0030316
GO:0030324
GO:0030331
GO:0030539
GO:0030856
GO:0030858
GO:0030877
GO:0030900
GO:0030901
GO:0030902
GO:0030997
GO:0031016
GO:0031069
GO:0031253
GO:0031528
GO:0031641
GO:0032200
GO:0032212
GO:0032331
GO:0032355
GO:0032968
GO:0032991
GO:0032993
GO:0033077
GO:0033234
GO:0034330
GO:0034332
GO:0034333
GO:0034394
GO:0034750
GO:0035050
GO:0035112
GO:0035115
GO:0035116
GO:0035315
GO:0035995
GO:0036023
GO:0036211
GO:0036520
GO:0042127
GO:0042129
GO:0042475
GO:0042733
GO:0042734
GO:0042981
GO:0042995
GO:0043065
GO:0043066
GO:0043123
GO:0043161
GO:0043226
GO:0043296
GO:0043410
GO:0043525
GO:0043588
GO:0044093
GO:0044325
GO:0044334
GO:0044336
GO:0044338
GO:0044339
GO:0045177
GO:0045202
GO:0045211
GO:0045294
GO:0045296
GO:0045453
GO:0045595
GO:0045596
GO:0045597
GO:0045603
GO:0045667
GO:0045669
GO:0045670
GO:0045671
GO:0045743
GO:0045765
GO:0045892
GO:0045893
GO:0045944
GO:0045976
GO:0046332
GO:0048145
GO:0048469
GO:0048471
GO:0048489
GO:0048513
GO:0048538
GO:0048568
GO:0048599
GO:0048617
GO:0048643
GO:0048660
GO:0048664
GO:0048709
GO:0048715
GO:0048856
GO:0048870
GO:0050767
GO:0050768
GO:0050808
GO:0051091
GO:0051145
GO:0051450
GO:0051571
GO:0051884
GO:0051973
GO:0060066
GO:0060070
GO:0060173
GO:0060439
GO:0060440
GO:0060441
GO:0060479
GO:0060484
GO:0060487
GO:0060492
GO:0060742
GO:0060767
GO:0060769
GO:0060789
GO:0060916
GO:0061047
GO:0061154
GO:0061198
GO:0061324
GO:0061549
GO:0061550
GO:0061629
GO:0070062
GO:0070161
GO:0070369
GO:0070411
GO:0070602
GO:0071363
GO:0071681
GO:0071944
GO:0072033
GO:0072053
GO:0072054
GO:0072079
GO:0072089
GO:0072182
GO:0072497
GO:0090090
GO:0090279
GO:0090425
GO:0090575
GO:0097091
GO:0097190
GO:0097718
GO:0098609
GO:0098685
GO:0098831
GO:0099092
GO:0140297
GO:1901135
GO:1901215
GO:1903204
GO:1904796
GO:1904798
GO:1904888
GO:1904948
GO:1904954
GO:1990138
GO:1990226
GO:1990403
GO:1990711
GO:1990791
GO:1990907
GO:1990909
GO:2000008
GO:2000017
GO:2000179
GO:2000288
GO:2000648
GO:2001234
HMNXSV003034293
Hs2.171271.2.S1_3p_s_at
ILMN_1651617
ILMN_1726641
ILMN_1746396
ILMN_1757350
PH_hs_0024820
TC03000214.hg
X87838_at
g4503130_3p_at
Participates
as a candidate of
Other forms of this molecule
CTNNB1 S45A [cytosol]
CTNNB1 S45C [cytosol]
CTNNB1 S45Y [cytosol]
CTNNB1 S45N [cytosol]
CTNNB1 S45P [cytosol]
pT41,S45-CTNNB1 S37P [cytosol]
pT41,S45-CTNNB1 S37F [cytosol]
pT41,S45-CTNNB1 S37A [cytosol]
pT41,S45-CTNNB1 S37Y [cytosol]
pT41,S45-CTNNB1 S37C [cytosol]
pS37,T41,S45-CTNNB1 S33A [cytosol]
pS37,T41,S45-CTNNB1 S33T [cytosol]
pS37,T41,S45-CTNNB1 S33C [cytosol]
pS37,T41,S45-CTNNB1 S33F [cytosol]
pS37,T41,S45-CTNNB1 S33P [cytosol]
pS37,T41,S45-CTNNB1 S33Y [cytosol]
pS45-CTNNB1 T41N [cytosol]
pS45-CTNNB1 T41A [cytosol]
pS45-CTNNB1 T41I [cytosol]
Ub-K,p-Y-CTNNB1 [cytosol]
p-Y-CTNNB1 [cytosol]
p-S552-CTNNB1 [nucleoplasm]
p-S552-CTNNB1 [cytosol]
CTNNB1 [plasma membrane]
p-S45 CTNNB1 [cytosol]
p-T41,S45 CTNNB1 [cytosol]
p-S37,T41,S45, CTNNB1 [cytosol]
p-S33,S37,T41,S45 CTNNB1 [cytosol]
CTNNB1(116-376) [cytosol]
CTNNB1(1-115) [cytosol]
CTNNB1 [cytosol]
CTNNB1 [nucleoplasm]
Modified Residues
Name
L-serine 45 replaced with L-phenylalanine
Coordinate
45
PsiMod
L-phenylalanine residue [MOD:00023]
A protein modification that effectively converts a source amino acid residue to L-phenylalanine.
L-serine removal [MOD:01646]
A protein modification that effectively removes or replaces an L-serine.
Disease
Name Identifier Synonyms
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
adrenal gland cancer DOID:3953 malignant neoplasm of adrenal gland, adrenal cancer, malignant neoplasm of adrenal gland NOS (disorder), adrenal neoplasm, neoplasm of adrenal gland (disorder), malignant tumor of adrenal gland (disorder), tumor of the Adrenal gland, malignant Adrenal tumor
colorectal cancer DOID:9256
hepatocellular carcinoma DOID:684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
kidney cancer DOID:263 malignant neoplasm of kidney except pelvis, malignant tumour of kidney, renal cancer
connective tissue cancer DOID:201 connective tissue neoplasm, neoplasm of connective tissues (disorder), Tumour of connective tissue
Cross References
RefSeq
OpenTargets
ZINC - Substances
ZINC target
PRO
PDB
COSMIC
HPA
GeneCards
Ensembl
ENSP00000495360, ENST00000642992, ENST00000645982, ENSP00000495244, ENSP00000494845, ENSP00000385604, ENSP00000401599, ENST00000645210, ENSP00000495992, ENSP00000494677, ENSP00000493610, ENSP00000494914, ENSP00000494053, ENSP00000495719, ENSP00000412219, ENSP00000409302, ENST00000433400, ENST00000645320, ENST00000644867, ENST00000642248, ENST00000647390, ENST00000450969, ENSP00000496385, ENST00000441708, ENSP00000379486, ENSP00000344456, ENST00000643031, ENST00000642426, ENSP00000387455, ENST00000643992, ENSP00000495076, ENST00000396183, ENST00000396185, ENST00000646369, ENSG00000168036, ENST00000643297, ENSP00000493533, ENST00000349496, ENST00000642315, ENST00000431914, ENSP00000494411, ENST00000646725, ENST00000643977, ENSP00000496180, ENSP00000379488, ENSP00000496021, ENSP00000495450, ENST00000643541, ENST00000405570
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (110)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9NQB0 TCF7L2  4 0.97 27
 UniProt:P25054 APC  20 0.953 19
 UniProt:P12830 CDH1  8 0.953 18
 UniProt:Q9NSA3 CTNNBIP1  1 0.952 16
 UniProt:P49841 GSK3B  4 0.947 19
 UniProt:P15884 TCF4  1 0.94 22
 UniProt:O15169 AXIN1  11 0.94 44
 UniProt:Q9Y297 BTRC  2 0.926 8
 UniProt:Q9UJU2 LEF1  2 0.893 10
 UniProt:P10275 AR  4 0.891 15
 UniProt:P19022 CDH2  3 0.887 8
 UniProt:P46937 YAP1  7 0.881 14
 UniProt:P33151 CDH5  2 0.857 7
 UniProt:P35221 CTNNA1  2 0.813 6
 UniProt:P36402 TCF7  1 0.779 4
 UniProt:O00512 BCL9  1 0.725 5
 UniProt:Q9UKB1 FBXW11  1 0.723 4
 UniProt:Q6P1J9 CDC73  1 0.714 10
 UniProt:Q5JTC6 AMER1  5 0.711 9
 UniProt:P02511 CRYAB  1 0.709 6
 UniProt:P63208 SKP1  2 0.692 3
 UniProt:O35625 Axin1  8 0.688 4
 UniProt:Q96AC1 FERMT2  1 0.681 13
 UniProt:O43707 ACTN4  3 0.68 7
 UniProt:Q08050 FOXM1  3 0.672 16
 UniProt:P42858 HTT  1 0.666 14
 UniProt:Q01826 SATB1  5 0.66 9
 UniProt:P55197 AF10      0.656 5
 UniProt:Q13761 RUNX3  7 0.656 12
 UniProt:O00482-1 NR5A2  1 0.65 5
 UniProt:P19838 NFKB1  8 0.646 3
 UniProt:Q9GZV5 WWTR1  3 0.641 4
 UniProt:P26358 DNMT1  2 0.628 8
 UniProt:P11362 FGFR1  9 0.623 3
 UniProt:P14923 JUP  6 0.615 3
 UniProt:Q67FY2  1 0.609 2
 UniProt:Q9YGY0 AXIN1      0.609 2
 UniProt:P23470 PTPRG      0.609 2
 UniProt:P08575 PTPRC  2 0.609 2
 UniProt:Q12913 PTPRJ  2 0.609 2
 UniProt:P49789 FHIT      0.602 4
 UniProt:Q9UI47-1 CTNNA3      0.602 4
 UniProt:P18012 IPAC      0.602 4
 UniProt:P49023 PXN  4 0.602 4
 UniProt:Q9UBN7 HDAC6  4 0.602 4
 UniProt:Q9GZQ8 MAP1LC3B  3 0.602 5
 UniProt:P50402 EMD  4 0.591 3
 UniProt:Q04206 RELA  6 0.589 3
 UniProt:Q13308 PTK7      0.581 5
 UniProt:Q9BZE0 GLIS2      0.581 6
 IntAct:EBI-4399559 UBIQ      0.576 3
 UniProt:O75564 JERKY      0.576 3
 UniProt:Q13625 TP53BP2  1 0.576 5
 UniProt:Q92793 CREBBP  4 0.573 2
 UniProt:P33724  5 0.571 5
 UniProt:P11388 TOP2A  3 0.57 5
 UniProt:Q8TEK3 DOT1L  1 0.564 3
 UniProt:Q9Y2T1 AXIN2  4 0.564 2
 UniProt:Q9DBG9  1 0.558 3
 UniProt:P01023 A2M  2 0.556 3
 UniProt:P62826 RAN  2 0.556 3
 UniProt:O00291 HIP1  7 0.556 3
 UniProt:O75400-2 PRPF40A      0.556 3
 UniProt:Q14114-3 Q141143      0.556 3
 UniProt:P13473-2 P134732      0.556 3
 UniProt:P23560-2 BDNF      0.556 3
 UniProt:O14656-2 TOR1A      0.556 3
 UniProt:Q7Z699 SPRED1  2 0.556 3
 UniProt:P35520 CBS  1 0.556 3
 UniProt:P51608 MECP2      0.556 3
 UniProt:Q8WXH2 JPH3      0.556 3
 UniProt:Q92915-2 FGF14      0.556 3
 UniProt:G5E9A7 G5E9A7      0.556 3
 UniProt:P04406 GAPDH  1 0.556 3
 UniProt:P19404 NDUFV2  1 0.556 3
 UniProt:P07900 HSP90AA1  8 0.556 3
 UniProt:P55212 CASP6  5 0.556 3
 UniProt:P14136 GFAP  3 0.556 3
 UniProt:P00519 ABL1  5 0.544 2
 UniProt:P12931 SRC  6 0.544 2
 UniProt:Q9NYF0 DACT1  1 0.537 3
 UniProt:Q8TEW0 PARD3  3 0.536 2
 IntAct:EBI-5237192 AXIN2      0.527 2
 UniProt:P09803 Cdh1  6 0.527 3
 UniProt:Q9UKE5 TNIK  1 0.525 3
 UniProt:Q9EPK5 Wwtr1  4 0.525 2
 UniProt:P14618 PKM  3 0.524 4
 UniProt:A1Z199 A1Z199      0.524 2
 UniProt:P14618-1 PKM  1 0.524 3
 UniProt:O14746 TERT  1 0.524 2
 UniProt:Q15599 NHRF2      0.508 2
 UniProt:Q03431 PTH1R  1 0.505 4
 UniProt:P08069 IGF1R  3 0.499 3
 UniProt:P18146 EGR1  1 0.499 7
 UniProt:Q9H6I2 SOX17  1 0.499 2
 UniProt:Q92597 NDRG1  1 0.499 3
 IntAct:EBI-6668710 TCF      0.499 3
 UniProt:Q9Y265 RUVBL1  1 0.499 3
 UniProt:P49757 NUMB  1 0.499 2
 UniProt:P16284 PECAM1  4 0.483 3
 UniProt:Q9UI47 CTNA3      0.483 2
 UniProt:Q99697 PITX2  1 0.483 2
 UniProt:P00533 EGFR  20 0.483 2
 UniProt:Q9JHQ5  1 0.471 2
 UniProt:P29474 NOS3  7 0.471 4
 UniProt:O95071 UBR5      0.463 6
 UniProt:Q14160 SCRIB  1 0.463 2
 UniProt:Q14526 HIC1  2 0.463 2
 UniProt:P46940 IQGAP1  3 0.463 3
 UniProt:Q99593 TBX5  1 0.462 3
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