Reactome | UniProt:P04637 TP53

UniProt:P04637 TP53

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

P53_HUMAN, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61

List of interactors in Reactome

Interactors (110)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
Q00987	7	MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.995	117
P04637	2	polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 [nucleoplasm] (R-HSA-69488)	0.98	33
Q09472	2	EP300 [nucleoplasm] (R-HSA-381325) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.976	22
Q93009	1	USP7 [nucleoplasm] (R-HSA-3215278)	0.969	23
P0CG48	10	UBC [cytosol] (R-HSA-8853531) UBC(1-76) [cytosol] (R-HSA-939188) UBC(153-228) [cytosol] (R-HSA-939258) UBC(229-304) [cytosol] (R-HSA-939192) UBC(305-380) [cytosol] (R-HSA-939232) UBC(381-456) [cytosol] (R-HSA-939191) UBC(457-532) [cytosol] (R-HSA-939184) UBC(533-608) [cytosol] (R-HSA-939239) UBC(609-684) [cytosol] (R-HSA-939165) UBC(77-152) [cytosol] (R-HSA-939164)	0.96	15
Q92793	3	CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.96	17
Q96EB6	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.957	18
Q14999	1	CUL7 [cytosol] (R-HSA-535534)	0.919	18
Q96PM5	1	RCHY1 [nucleoplasm] (R-HSA-5655134)	0.892	13
Q12888	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.87	8
Q13526	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.846	14
P45481	3	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.845	10
Q9UER7	2	DAXX [nucleoplasm] (R-HSA-3222068) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.84	12
Q15672	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.817	10
Q8WUF5	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.815	12
P38646	2	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968)	0.811	6
Q9NRG4	1	SMYD2 [nucleoplasm] (R-HSA-3222233)	0.806	6
O14641	1	DVL2 [cytosol] (R-HSA-201694)	0.778	6
P38936	2	CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585)	0.778	5
Q923E4	2	Sirt1 [nucleoplasm] (R-MMU-5211238) SIRT1 [nucleoplasm] (R-MMU-427531)	0.766	4
Q05397	5	p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) pY-PTK2 [cytosol] (R-HSA-9632393)	0.751	13
P09874	3	monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PARP1 [nucleoplasm] (R-HSA-201568) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.75	5
P09429	2	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221)	0.74	9
P31947	1	SFN [cytosol] (R-HSA-1445105)	0.738	5
P53350	4	p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603) PLK1 [nucleoplasm] (R-HSA-156720)	0.737	6
P63279	3	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [cytosol] (R-HSA-4655342) UBE2I [nucleoplasm] (R-HSA-912481)	0.737	5
Q9NPI1	1	BRD7 [nucleoplasm] (R-HSA-3222092)	0.729	9
O14503	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.728	11
Q9UBL3	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.723	8
P63165	2	SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831)	0.722	3
Q8NHY2	3	p-S387-RFWD2 [cytosol] (R-HSA-349439) p-S387-RFWD2 [nucleoplasm] (R-HSA-349450) RFWD2 [nucleoplasm] (R-HSA-349454)	0.717	5
Q13547	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.713	7
Q9H2X6	2	HIPK2 [nucleoplasm] (R-HSA-3215222) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.713	3
P42858	1	HTT [nucleoplasm] (R-HSA-9023590)	0.709	19
P13569	5	CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR G551D [plasma membrane] (R-HSA-5678977) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	18
P29590	4	monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.7	4
P61964	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.69	5
Q15291	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.69	5
P02829	1	HSP90AB1 [cytosol] (R-SCE-419617)	0.678	8
P06748	6	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) NPM1 [cytosol] (R-HSA-3008211) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) p-S4-NPM1 [cytosol] (R-HSA-6801679) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056)	0.676	6
Q15796	1	SMAD2 [cytosol] (R-HSA-3006353)	0.674	7
P63104	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.669	3
P31948	1	STIP1 [cytosol] (R-HSA-443857)	0.666	4
P04792	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.665	3
P49841	2	GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.658	3
P17844	4	DDX5 [cytosol] (R-HSA-9682643) DDX5 [nucleoplasm] (R-HSA-3900136) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186)	0.656	6
P51587	2	BRCA2 [cytosol] (R-HSA-9709265) BRCA2 [nucleoplasm] (R-HSA-50951)	0.655	7
Q14191	2	monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904) WRN [nucleoplasm] (R-HSA-67387)	0.647	5
O96017	3	CHEK2 [nucleoplasm] (R-HSA-113824) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.646	3
Q06330	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.645	5
Q9Y618	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.645	7
Q9UPR3	1	SMG5 [cytosol] (R-HSA-927867)	0.643	3
Q6NYC1	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.639	7
P49757	1	NUMB [plasma membrane] (R-HSA-443595)	0.632	5
Q9Y3T9	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.632	8
P04271	1	S100B [extracellular region] (R-HSA-879433)	0.623	3
Q8N726	3	p14ARF [cytosol] (R-HSA-9645669) p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.623	3
P35232	1	PHB [cytosol] (R-HSA-5672944)	0.619	6
Q9Y265	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.619	10
Q86TM6	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.61	5
O14920	3	IKBKB [cytosol] (R-HSA-168114) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.609	2
P41235	1	HNF4A [nucleoplasm] (R-HSA-446162)	0.604	3
P15036	2	ETS2 [nucleoplasm] (R-HSA-1629811) p-T72-ETS2 [nucleoplasm] (R-HSA-3132735)	0.602	4
Q05655	5	p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) PRKCD [cytosol] (R-HSA-58200) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [cytosol] (R-HSA-212551)	0.602	4
Q9UHC7	2	MKRN1 [cytosol] (R-HSA-976042) p-S109-MKRN1 [cytosol] (R-HSA-8948758)	0.602	8
Q9UHH9	1	IP6K2 [nucleoplasm] (R-HSA-1015687)	0.602	4
Q9P0U4	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.597	7
O60285	2	NUAK1 [nucleoplasm] (R-HSA-3222004) p-T211-NUAK1 [nucleoplasm] (R-HSA-3222011)	0.591	5
Q8TAQ5	2	p-S68-ZNF420 [nucleoplasm] (R-HSA-6799095) ZNF420 [nucleoplasm] (R-HSA-1247509)	0.591	4
O14980	2	XPO1 [cytosol] (R-HSA-165539) XPO1 [nucleoplasm] (R-HSA-165529)	0.589	3
P08047	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.589	6
P61978	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.589	2
Q96ST3	2	monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071) SIN3A [nucleoplasm] (R-HSA-351657)	0.589	2
P22736	2	NR4A1 [nucleoplasm] (R-HSA-199831) p-S351-NR4A1 [nucleoplasm] (R-HSA-199846)	0.581	6
P61289	1	PSME3 [cytosol] (R-HSA-68816)	0.576	7
O75925	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.571	4
P10415	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.564	5
Q9H7Z6	1	KAT8 [nucleoplasm] (R-HSA-3321802)	0.564	2
P00519	5	ABL1 [cytosol] (R-HSA-375987) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.558	2
P19338	2	NCL [nucleoplasm] (R-HSA-6791213) NCL [plasma membrane] (R-HSA-9836466)	0.558	2
P17676	3	CEBPB [nucleoplasm] (R-HSA-381378) p-T235, S321-CEBPB [nucleoplasm] (R-HSA-3857339) p-T235-CEBPB [nucleoplasm] (R-HSA-3857343)	0.556	4
P46821	1	MAP1B(2-2206) [cytosol] (R-HSA-9836954)	0.556	6
P55212	1	CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
Q15424	3	monoSUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343) polySUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) SAFB [nucleoplasm] (R-HSA-4085379)	0.556	5
P04183	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
P04731	1	MT1A [cytosol] (R-HSA-5660412)	0.544	3
P29066	1	ARRB1 [cytosol] (R-RNO-264470)	0.544	3
P38398	3	BRCA1 [nucleoplasm] (R-HSA-50949) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624)	0.544	2
Q8R5A0	1	SMYD2 [nucleoplasm] (R-MMU-3222233)	0.544	3
P11473	2	polySUMO2-VDR [nucleoplasm] (R-HSA-4546376) VDR [nucleoplasm] (R-HSA-375512)	0.537	6
O43524	11	Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3 [cytosol] (R-HSA-5687032) FOXO3 [nucleoplasm] (R-HSA-199305) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289)	0.536	2
O15047	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.532	4
P06400	4	hyperphosphorylated RB1 [nucleoplasm] (R-HSA-188389) RB1 [cytosol] (R-HSA-9660621) RB1 [nucleoplasm] (R-HSA-68642) RB1 T738_R775del [nucleoplasm] (R-HSA-9661042)	0.527	2
P17987	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
Q15831	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.527	2
Q9UNE7	1	STUB1 [cytosol] (R-HSA-975970)	0.527	3
O15169	1	AXIN1 [cytosol] (R-HSA-195249)	0.524	4
O95863	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.524	2
Q15648	1	MED1 [nucleoplasm] (R-HSA-212445)	0.524	3
Q92841	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.524	3
O75928	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.519	2
Q86Z02	1	HIPK1 [nucleoplasm] (R-HSA-3215224)	0.508	2
Q8N2W9	2	monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415) PIAS4 [nucleoplasm] (R-HSA-2993789)	0.508	2
P49407	1	ARRB1 [cytosol] (R-HSA-264470)	0.499	5
Q8N9N5	1	BANP [nucleoplasm] (R-HSA-3221973)	0.499	3
Q92993	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.499	3
P16885	5	p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [plasma membrane] (R-HSA-114601)	0.488	2
Q16666	1	IFI16 [cytosol] (R-HSA-1834934)	0.488	2
Q96CJ1	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.488	2
O70445	1	Bard1 [nucleoplasm] (R-MMU-5659775)	0.463	2

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