Reactome | CCT2 [cytosol]

CCT2 [cytosol]

Stable Identifier

R-HSA-390464

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit beta (TCP-1-beta)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P78371 CCT2

Gene Names

CCT2, 99D8.1, CCTB

Chain

initiator methionine:, chain:2-535

Reference Genes

BioGPS Gene:10576 CCT2

COSMIC (genes):CCT2 CCT2

CTD Gene:10576 CCT2

dbSNP Gene:10576 CCT2

ENSEMBL:ENSG00000166226 CCT2

ENSEMBL_homo_sapiens_GENE:ENSG00000166226.13 CCT2

HGNC:1615 CCT2

KEGG Gene (Homo sapiens):10576 CCT2

Monarch:10576 CCT2

NCBI Gene:10576 CCT2

OMIM:605139 CCT2

UCSC:P78371 CCT2

Reference Transcript

Other Identifiers

10576

11715420_a_at

11715421_a_at

16753964

201946_PM_s_at

201946_s_at

201947_PM_s_at

201947_s_at

3421631

3421632

3421633

3421634

3421635

3421636

3421637

3421638

3421640

3421643

3421644

3421645

3421650

3421652

3421653

3421654

3421655

3421656

3421657

3421658

3421661

3421666

3421667

3421668

3421669

35759_at

7957052

A_23_P105392

GE61414

GO:0000166

GO:0002199

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006457

GO:0007339

GO:0016787

GO:0016887

GO:0022414

GO:0031410

GO:0031625

GO:0032200

GO:0032212

GO:0035578

GO:0043226

GO:0044183

GO:0044297

GO:0050821

GO:0051082

GO:0051086

GO:0051131

GO:0051973

GO:0061077

GO:0065003

GO:0070062

GO:0090666

GO:0140657

GO:0140662

GO:1904851

GO:1904871

GO:1904874

HMNXSV003028752

Hs.6456.0.S1_3p_a_at

ILMN_1679382

PH_hs_0022906

PH_hs_0040227

TC12000616.hg

U91327_at

g5453602_3p_a_at

g5453602_3p_x_at

Participates

as a candidate of

as a component of

Other forms of this molecule

CCT2 [extracellular region]

CCT2 [azurophil granule lumen]

Inferred To

CCT2 [cytosol] (Bos taurus)

CCT2 [cytosol] (Canis familiaris)

CCT2 [cytosol] (Drosophila melanogaster)

CCT2 [cytosol] (Gallus gallus)

CCT2 [cytosol] (Plasmodium falciparum)

CCT2 [cytosol] (Saccharomyces cerevisiae)

CCT2 [cytosol] (Sus scrofa)

cct2 [cytosol] (Dictyostelium discoideum)

cct2 [cytosol] (Schizosaccharomyces pombe)

cct2 [cytosol] (Xenopus tropicalis)

Cct2 [cytosol] (Mus musculus)

Cct2 [cytosol] (Rattus norvegicus)

cct-2 [cytosol] (Caenorhabditis elegans)

Ghost homologue of CCT2 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_006422.1, NP_001185771.1

OpenTargets

ENSG00000166226

GeneCards

P78371

HPA

ENSG00000166226-CCT2

Ensembl

ENSG00000166226, ENSP00000299300, ENST00000299300, ENST00000543146, ENSP00000445471

PRO

P78371

Pharos - Targets

P78371

PDB

6NRB, 8SHN, 7NVL, 8SH9, 8SG8, 7TTN, 7X7Y, 6NRA, 7TTT, 8SHL, 8SGQ, 7TRG, 8SGC, 8SHG, 8SFE, 7LUP, 8HKI, 8SGL, 7WZ3, 8SHF, 6NRD, 8SHA, 8I9U, 8SHD, 7X3J, 6QB8, 7NVO, 7LUM, 7X0S, 8SHP, 7X0V, 6NRC, 7WU7, 8SHO, 7X6Q, 6NR9, 8SFF, 8SHE, 6NR8, 7X0A, 7X3U, 7NVM, 8SHQ, 7TUB, 8SG9, 8I1U, 8IB8, 8SHT, 7NVN

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.813	7
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.788	8
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.758	5
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.69	6
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.643	5
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	17
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.597	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	10
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.527	4
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q13371 PDCL	2	p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228) PDCL [cytosol] (R-HSA-6813727)	0.527	4
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.527	2
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.527	2
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.527	3
UniProt:O94953 KDM4B	2	K48PolyUb-KDM4B [nucleoplasm] (R-HSA-5683074) KDM4B [nucleoplasm] (R-HSA-3214396)	0.527	3
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.527	3
UniProt:O00628 PEX7	2	PEX7 [peroxisomal membrane] (R-HSA-9033493) PEX7 [cytosol] (R-HSA-9033107)	0.527	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	6
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.527	3
UniProt:Q7Z6Z6 PNPLA5	1	PNPLA5 [cytosol] (R-HSA-8848346)	0.527	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775)	0.499	2

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