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Go!
NCL [nucleoplasm]
Stable Identifier
R-HSA-6791213
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleolin, NUCL_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)
NCL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19338 NCL
Gene Names
NCL
Chain
initiator methionine:, chain:2-710
Reference Genes
BioGPS Gene:4691 NCL
COSMIC (genes):NCL NCL
CTD Gene:4691 NCL
dbSNP Gene:4691 NCL
ENSEMBL:ENSG00000115053 NCL
ENSEMBL_homo_sapiens_GENE:ENSG00000115053.17 NCL
HGNC:7667 NCL
KEGG Gene (Homo sapiens):4691 NCL
Monarch:4691 NCL
NCBI Gene:4691 NCL
OMIM:164035 NCL
UCSC:P19338 NCL
Reference Transcript
RefSeq:NM_005381.2 NCL
Other Identifiers
11745154_a_at
11745155_s_at
16909491
200610_PM_s_at
200610_s_at
241892_PM_at
241892_at
2603459
2603461
2603462
2603463
2603465
2603466
2603467
2603468
2603471
2603473
2603474
2603477
2603479
2603481
2603483
2603485
2603486
2603487
2603488
2603489
2603490
2603491
2603492
2603493
2603495
2603496
2603498
32590_at
4691
8059689
A_23_P5551
GE81501
GO:0001525
GO:0001533
GO:0003676
GO:0003677
GO:0003723
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005681
GO:0005694
GO:0005730
GO:0005737
GO:0005886
GO:0005938
GO:0006351
GO:0006355
GO:0016020
GO:0016071
GO:0017148
GO:0023052
GO:0036211
GO:0036464
GO:0042162
GO:0042731
GO:0042802
GO:0043226
GO:0043560
GO:0044547
GO:0045944
GO:0046627
GO:0048026
GO:0048027
GO:0048856
GO:0050730
GO:0070062
GO:0071364
GO:1901838
GO:1990830
GO:1990904
HMNXSV003009139
Hs.253767.0.A1_3p_at
ILMN_1695422
ILMN_2121437
M60858_rna1_at
PH_hs_0004572
TC02002859.hg
g4885510_3p_a_at
This entity regulates
Positively
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA
(Homo sapiens)
Other forms of this molecule
NCL [plasma membrane]
NCL [macropinosome membrane]
Inferred To
NCL [nucleoplasm]
(Bos taurus)
NCL [nucleoplasm]
(Canis familiaris)
NCL [nucleoplasm]
(Dictyostelium discoideum)
NCL [nucleoplasm]
(Gallus gallus)
NCL [nucleoplasm]
(Sus scrofa)
Ncl [nucleoplasm]
(Mus musculus)
Ncl [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_005372.2
OpenTargets
ENSG00000115053
GeneCards
P19338
HPA
ENSG00000115053-NCL
Ensembl
ENSP00000318195
,
ENST00000322723
,
ENSG00000115053
PRO
P19338
Pharos - Targets
P19338
PDB
2KRR
,
2FC8
,
2FC9
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P39060-PRO_0000005794 COL18A1
0.784
12
ChEBI:28304 HEPARIN
0.722
3
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.71
8
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.643
5
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.643
4
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.615
3
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.59
3
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.59
2
UniProt:O95793 STAU1
0.577
3
UniProt:P16401 H1-5
1
HIST1H1B [nucleoplasm]
(R-HSA-211248)
0.564
2
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.558
2
UniProt:P19338 NCL
3
NCL [plasma membrane]
(R-HSA-9836466)
NCL [macropinosome membrane]
(R-HSA-9837666)
NCL [nucleoplasm]
(R-HSA-6791213)
0.558
5
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.547
2
UniProt:O75940 SMNDC1
1
SMNDC1 [nucleoplasm]
(R-HSA-8865958)
0.536
2
UniProt:Q99608 NDN
1
NDN [nucleoplasm]
(R-HSA-6789966)
0.536
2
UniProt:P61513 RPL37A
1
RPL37A [cytosol]
(R-HSA-72468)
0.527
2
UniProt:P36578 RPL4
1
RPL4 [cytosol]
(R-HSA-72474)
0.527
2
UniProt:Q15050 RRS1
0.527
2
UniProt:Q4G0J3 LARP7
0.527
2
UniProt:P62913 RPL11
1
RPL11 [cytosol]
(R-HSA-72406)
0.527
2
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
2
UniProt:Q9CR42 ANKR1
0.524
2
UniProt:Q14684-1 RRP1B
0.512
4
UniProt:Q9UQ80 PA2G4
2
PA2G4 [extracellular region]
(R-HSA-6806200)
PA2G4 [azurophil granule lumen]
(R-HSA-6799205)
0.499
2
UniProt:Q8AZK7 EBNA5
0.499
2
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
3
UniProt:Q9Y6D6 BIG1
0.499
5
IntAct:EBI-1549316 PROBE
0.499
2
IntAct:EBI-1549314 PROBE
0.499
2
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.499
3
UniProt:P62280 RPS11
2
RPS11 [nucleoplasm]
(R-HSA-6791212)
RPS11 [cytosol]
(R-HSA-72327)
0.483
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
10
UniProt:P62753 RPS6
4
RPS6 [nucleoplasm]
(R-HSA-6790606)
3OHR147-RPS6 [cytosol]
(R-HSA-9629876)
p-5S-RPS6 [cytosol]
(R-HSA-165727)
RPS6 [cytosol]
(R-HSA-72381)
0.483
2
UniProt:P62140 PPP1CB
4
PPP1CB [cytosol]
(R-HSA-163405)
PPP1CB [nucleoplasm]
(R-HSA-62003)
PPP1CB P49R [cytosol]
(R-HSA-9660547)
PPP1CB A56P [cytosol]
(R-HSA-9660543)
0.463
2
UniProt:P27958-PRO_0000037577
0.463
4
UniProt:P61586 RHOA
6
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
RHOA [cytosol]
(R-HSA-194866)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [plasma membrane]
(R-HSA-194510)
0.463
3
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.463
3
UniProt:Q01130 SRSF2
1
SRSF2 [nucleoplasm]
(R-HSA-72033)
0.463
2
UniProt:Q8N0X7 SPART
0.462
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
IntAct:EBI-5333170 SSRNA
0.462
3
IntAct:EBI-5333168 SSRNA
0.462
4
IntAct:EBI-5333262 SSDNA
0.462
4
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