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SERPINE1 [plasma membrane]
Stable Identifier
R-HSA-158922
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
plasminogen activator inhibitor 1, PAI-1
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Dissolution of Fibrin Clot (Homo sapiens)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431):SERPINE1 [plasma membrane] (Homo sapiens)
SERPINE1 [plasma membrane] (Homo sapiens)
SERPINE1-like proteins [plasma membrane] (Homo sapiens)
SERPINE1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05121 SERPINE1
Gene Names
SERPINE1, PAI1, PLANH1
Chain
signal peptide:1-23, chain:24-402
Reference Genes
BioGPS Gene:5054 SERPINE1
COSMIC (genes):SERPINE1 SERPINE1
CTD Gene:5054 SERPINE1
dbSNP Gene:5054 SERPINE1
ENSEMBL:ENSG00000106366 SERPINE1
HGNC:8583 SERPINE1
KEGG:hsa:5054 SERPINE1
Monarch:5054 SERPINE1
NCBI Gene:5054 SERPINE1
OMIM:173360 SERPINE1
UCSC:P05121 SERPINE1
Reference Transcript
RefSeq:NM_000602.4 SERPINE1
Other Identifiers
11715636_a_at
11746856_a_at
11757312_x_at
17049676
202627_PM_s_at
202627_s_at
202628_PM_s_at
202628_s_at
3016149
3016150
3016153
3016154
3016158
3016161
3016163
3016166
3016168
3016170
3016172
38125_at
5054
672_at
8135069
A_14_P105272
A_14_P119092
A_24_P158089
GE57824
GO:0001525
GO:0002020
GO:0004867
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0010469
GO:0010757
GO:0010951
GO:0014912
GO:0030194
GO:0030195
GO:0030312
GO:0030336
GO:0031012
GO:0031093
GO:0032757
GO:0033629
GO:0035491
GO:0042730
GO:0043226
GO:0045766
GO:0048260
GO:0050729
GO:0050829
GO:0051918
GO:0061044
GO:0061045
GO:0062023
GO:0070062
GO:0071222
GO:0090026
GO:0090399
GO:0097180
GO:0097187
GO:0098542
GO:0098772
GO:1901331
GO:1902042
GO:1904090
GO:2000098
GO:2000352
HMNXSV003055269
Hs.82085.0.S1_3p_a_at
ILMN_1744381
J03764_at
PH_hs_0024995
TC07000643.hg
TC07002499.hg
X04729_s_at
g10835158_3p_a_at
Participates
as a component of
PI-PLAUR:PLAU(21-177):PLAU(179-431):SERPINE1 [plasma membrane] (Homo sapiens)
as a member of
SERPINE1-like proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
SERPINE1 [extracellular region]
SERPINE1 [platelet alpha granule lumen]
Inferred To
Homologues of SERPINE1 [plasma membrane]
(Sus scrofa)
SERPINE1 [plasma membrane]
(Bos taurus)
SERPINE1 [plasma membrane]
(Canis familiaris)
SERPINE1 [plasma membrane]
(Sus scrofa)
Serpine1 [plasma membrane]
(Mus musculus)
Serpine1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000593.1
OpenTargets
ENSG00000106366
ENSEMBL
ENST00000223095
,
ENSP00000223095
ZINC - Substances
PAI1_HUMAN
ZINC - Biogenic
PAI1_HUMAN
ZINC target
P05121
PRO
P05121
PDB
1OC0
,
5ZLZ
,
3R4L
,
3EOX
,
5BRR
,
4AQH
,
3PB1
,
3CVM
,
6I8S
,
4G8R
,
1B3K
,
1DVM
,
1DVN
,
7AQF
,
3Q03
,
7AQG
,
3Q02
,
1LJ5
,
6ZRV
,
6GWN
,
1DB2
,
1C5G
,
3UT3
,
4G8O
,
6GWP
,
4IC0
,
6GWQ
,
1A7C
,
9PAI
ZINC - Investigational
PAI1_HUMAN
HPA
ENSG00000106366-SERPINE1
Pharos - Targets
P05121
Orphanet
SERPINE1
ZINC - Predictions - Purchasable
PAI1_HUMAN
HMDB Protein
HMDBP01864
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96EQ0 SGTB
0.718
6
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.718
6
UniProt:P00749 PLAU
6
PLAU(21-431) [specific granule membrane]
(R-HSA-6799705)
PLAU(21-431) [plasma membrane]
(R-HSA-158945)
PLAU(21-431) [tertiary granule membrane]
(R-HSA-6800974)
PLAU(21-431) [extracellular region]
(R-HSA-158979)
PLAU(179-431) [plasma membrane]
(R-HSA-158970)
PLAU(21-177) [plasma membrane]
(R-HSA-158956)
0.59
2
ChEBI:28304 HEPARIN
0.564
2
UniProt:O43711 TLX3
0.556
3
UniProt:P78337 PITX1
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q9UMX0-2 UBQLN1
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P02763 ORM1
4
ORM1 [platelet alpha granule lumen]
(R-HSA-8848906)
ORM1 [tertiary granule lumen]
(R-HSA-6801026)
ORM1 [extracellular region]
(R-HSA-6799687)
ORM1 [specific granule lumen]
(R-HSA-6799632)
0.537
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
10
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