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OGDH [mitochondrial matrix]
Stable Identifier
R-HSA-69981
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
alpha-ketoglutarate dehydrogenase E1 apoenzyme, 2-oxoglutarate dehydrogenase E1, ODO1_HUMAN, 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor , Alpha-ketoglutarate dehydrogenase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
OGDH complex synthesizes succinyl-CoA from 2-OG (Homo sapiens)
DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
OGDH dimer [mitochondrial matrix] (Homo sapiens)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
DLST transfers succinyl to CoA (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
OGDH dimer [mitochondrial matrix] (Homo sapiens)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
OGDH dimer decarboxylates 2-OG (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
OGDH dimer [mitochondrial matrix] (Homo sapiens)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
OGDH dimer [mitochondrial matrix] (Homo sapiens)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Glycine degradation (Homo sapiens)
DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
OGDH dimer [mitochondrial matrix] (Homo sapiens)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
LONP1 binds mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
LONP1 degrades mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
OGDH [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02218 OGDH
Gene Names
OGDH
Chain
transit peptide:1-40, chain:41-1023
Reference Genes
BioGPS Gene:4967 OGDH
COSMIC (genes):OGDH OGDH
CTD Gene:4967 OGDH
dbSNP Gene:4967 OGDH
ENSEMBL:ENSG00000105953 OGDH
HGNC:8124 OGDH
KEGG:hsa:4967 OGDH
Monarch:4967 OGDH
NCBI Gene:4967 OGDH
OMIM:613022 OGDH
UCSC:Q02218 OGDH
Reference Transcript
RefSeq:NM_002541.3 OGDH
RefSeq:NM_001003941.2 OGDH
RefSeq:NM_001165036.1 OGDH
Other Identifiers
11720752_at
11733916_at
11733917_x_at
11750633_a_at
1554151_3p_at
1554151_PM_at
1554151_at
1554152_PM_a_at
1554152_a_at
17045674
201282_PM_at
201282_at
2999949
2999954
2999956
2999967
2999969
2999970
2999971
2999974
2999976
2999978
2999979
2999980
2999981
2999982
2999984
2999989
2999990
2999991
2999992
2999993
2999994
2999995
2999996
2999997
2999998
3000002
3000003
3000004
3000005
40470_at
4967
78194_at
8132592
A_14_P121386
A_23_P123133
A_24_P290770
A_24_P9454
D10523_at
GE57043
GO:0003824
GO:0004591
GO:0005515
GO:0005634
GO:0005739
GO:0005759
GO:0005975
GO:0006091
GO:0006096
GO:0006099
GO:0006103
GO:0006104
GO:0006790
GO:0016491
GO:0016624
GO:0021695
GO:0021756
GO:0021766
GO:0021794
GO:0021860
GO:0022028
GO:0030976
GO:0031966
GO:0034602
GO:0043226
GO:0045252
GO:0046872
GO:0048856
GO:0048870
GO:0055086
GO:0061034
GO:1901135
HMNXSV003014052
HMNXSV003029712
ILMN_1733869
ILMN_1747159
ILMN_1783266
PH_hs_0031965
TC07000276.hg
g4505492_3p_at
Participates
as a member of
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Homo sapiens)
Inferred To
ogdh [mitochondrial matrix]
(Xenopus tropicalis)
Ghost homologue of OGDH [mitochondrial matrix]
(Danio rerio)
OGDH [mitochondrial matrix]
(Bos taurus)
OGDH [mitochondrial matrix]
(Caenorhabditis elegans)
OGDH [mitochondrial matrix]
(Canis familiaris)
OGDH [mitochondrial matrix]
(Dictyostelium discoideum)
OGDH [mitochondrial matrix]
(Gallus gallus)
OGDH [mitochondrial matrix]
(Mus musculus)
OGDH [mitochondrial matrix]
(Plasmodium falciparum)
OGDH [mitochondrial matrix]
(Rattus norvegicus)
OGDH [mitochondrial matrix]
(Saccharomyces cerevisiae)
OGDH [mitochondrial matrix]
(Schizosaccharomyces pombe)
OGDH [mitochondrial matrix]
(Sus scrofa)
Homologues of OGDH [mitochondrial matrix]
(Drosophila melanogaster)
Ogdh1 [mitochondrial matrix]
(Drosophila melanogaster)
Ogdh2 [mitochondrial matrix]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001003941.1
,
NP_002532.2
,
NP_001158508.1
ENSEMBL
ENST00000449767
,
ENSP00000392878
,
ENSG00000105953
,
ENSP00000222673
,
ENST00000222673
,
ENSP00000388084
,
ENST00000443864
OpenTargets
ENSG00000105953
GeneCards
OGDH
HPA
ENSG00000105953-OGDH
PRO
Q02218
Pharos - Targets
Q02218
GlyGen
Q02218
Orphanet
OGDH
HMDB Protein
HMDBP00439
PDB
7WGR
,
8I0K
,
3ERY
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
10
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