Reactome | SDHA [mitochondrial inner membrane]

SDHA [mitochondrial inner membrane]

Stable Identifier

R-HSA-70983

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Succinate Dehydrogenase complex subunit A, Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial, Fp, Flavoprotein subunit of complex II

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
    - Citric acid cycle (TCA cycle) (Homo sapiens)
      - Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)
        
        SDH complex (ox.) [mitochondrial inner membrane] (Homo sapiens)
        
        Succinate dehydrogenase flavoprotein (subunit A), oxidised [mitochondrial inner membrane] (Homo sapiens)
        
        SDHA [mitochondrial inner membrane] (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Transfer of electrons through the succinate dehydrogenase complex (Homo sapiens)
        
        SDH complex (ox.) [mitochondrial inner membrane] (Homo sapiens)
        
        Succinate dehydrogenase flavoprotein (subunit A), oxidised [mitochondrial inner membrane] (Homo sapiens)
        
        SDHA [mitochondrial inner membrane] (Homo sapiens)
        
        Succinate dehydrogenase complex (reduced) [mitochondrial inner membrane] (Homo sapiens)
        
        Succinate dehydrogenase flavoprotein (subunit A) [mitochondrial inner membrane] (Homo sapiens)
        
        SDHA [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P31040 SDHA

Gene Names

SDHA, SDH2, SDHF

Chain

transit peptide:1-42, chain:43-664

Reference Genes

BioGPS Gene:6389 SDHA

COSMIC (genes):SDHA SDHA

CTD Gene:6389 SDHA

dbSNP Gene:6389 SDHA

ENSEMBL:ENSG00000073578 SDHA

HGNC:10680 SDHA

KEGG Gene (Homo sapiens):6389 SDHA

Monarch:6389 SDHA

NCBI Gene:6389 SDHA

OMIM:600857 SDHA

UCSC:P31040 SDHA

Reference Transcript

Other Identifiers

11744078_s_at

11747729_s_at

11747868_x_at

11749757_x_at

201093_x_at

222021_3p_x_at

222021_x_at

2659048

2659053

2659062

2659063

2659065

2659087

2659090

2659092

2712552

2712554

2712556

2712558

2712563

2712573

2712574

2712575

2712576

2712577

2712582

2712586

2712589

2713507

2713513

2713525

2798540

2798541

2798543

2798544

2798546

2798547

2798548

2798550

2798553

2798554

2798555

2798556

2798559

2798560

2798565

2798566

2798567

2798571

2798575

2798576

2798577

2846060

2846061

2846064

2846066

2846069

2846070

2846088

34826_at

6389

8084912

8093039

8104166

GO:0000104

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005743

GO:0005749

GO:0006091

GO:0006099

GO:0006105

GO:0006121

GO:0007399

GO:0008150

GO:0008177

GO:0009055

GO:0016020

GO:0016491

GO:0016627

GO:0022900

GO:0022904

GO:0032991

GO:0043167

GO:0043226

GO:0044281

GO:0048856

GO:0050660

GO:0055114

HMNXSV003018881

HMNXSV003039244

HMNXSV003052645

Hs.469.2.S1_3p_s_at

ILMN_1651664

ILMN_1734640

ILMN_1744210

L21936_at

g4759079_3p_s_at

Participates

as a component of

Inferred To

Sdha [mitochondrial inner membrane] (Mus musculus)

Sdha [mitochondrial inner membrane] (Rattus norvegicus)

sdhA [mitochondrial inner membrane] (Dictyostelium discoideum)

sdha-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

sdh1 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

SDHA [mitochondrial inner membrane] (Canis familiaris)

SDHA [mitochondrial inner membrane] (Gallus gallus)

SdhA [mitochondrial inner membrane] (Drosophila melanogaster)

sdha [mitochondrial inner membrane] (Danio rerio)

sdha [mitochondrial inner membrane] (Xenopus tropicalis)

SDH1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001281261.1, NP_004159.2

OpenTargets

ENSG00000073578

IntEnz

1.3.5.1

HPA

ENSG00000073578-SDHA

GeneCards

P31040

Ensembl

ENSG00000073578, ENST00000264932, ENSP00000264932, ENST00000510361, ENSP00000427703

PRO

P31040

Pharos - Targets

P31040

Orphanet

15261

GlyGen

P31040

HMDB Protein

HMDBP00150

PDB

6VAX

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	8
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) PTPN3 [cytosol] (R-HSA-8867650) p-S459 PTPN3 [cytosol] (R-HSA-8868111)	0.499	2