Reactome | RPS6 [cytosol]

RPS6 [cytosol]

Stable Identifier

R-HSA-72381

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 6, P10660, 40S ribosomal protein S6, Phosphoprotein NP33

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
    - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
      - EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
      - tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - IMPACT binds GCN1 (Homo sapiens)
      - GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
      - tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62753 RPS6

Gene Names

RPS6, OK/SW-cl.2

Chain

chain:1-249

Reference Genes

BioGPS Gene:6194 RPS6

COSMIC (genes):RPS6 RPS6

CTD Gene:6194 RPS6

dbSNP Gene:6194 RPS6

ENSEMBL:ENSG00000137154 RPS6

HGNC:10429 RPS6

KEGG Gene (Homo sapiens):6194 RPS6

Monarch:6194 RPS6

NCBI Gene:6194 RPS6

OMIM:180460 RPS6

UCSC:P62753 RPS6

Reference Transcript

RefSeq:NM_001010.2 RPS6

Other Identifiers

0005700403

11719464_x_at

11763007_x_at

17092737

18670421

18670422

18670423

18670425

18670426

18670429

18670432

200081_PM_s_at

200081_s_at

201254_x_at

209134_s_at

3200714

3200715

3200716

3200718

3200719

3200724

3200725

3200726

3200728

3200733

35125_at

3822012

4012811

6194

8160308

91667_at

A_23_P123563

GO:0000003

GO:0000082

GO:0000184

GO:0000278

GO:0001890

GO:0002309

GO:0002376

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005844

GO:0006364

GO:0006412

GO:0006413

GO:0006605

GO:0006614

GO:0006810

GO:0006924

GO:0007049

GO:0007093

GO:0007165

GO:0007369

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009056

GO:0009058

GO:0009790

GO:0015031

GO:0015935

GO:0016020

GO:0019083

GO:0019899

GO:0019901

GO:0022605

GO:0022627

GO:0030154

GO:0030425

GO:0031929

GO:0032991

GO:0033077

GO:0034641

GO:0034655

GO:0036464

GO:0042254

GO:0042274

GO:0042592

GO:0042593

GO:0043065

GO:0043066

GO:0043226

GO:0044297

GO:0044403

GO:0048471

GO:0048821

GO:0048856

GO:1990904

ILMN_1656791

ILMN_1808939

M77232_rna1_at

PH_hs_0030081

PH_hs_0039702

TC09000936.hg

TC09000938.hg

g12751054_3p_s_at

Participant Of

input

Phosphorylation of Ribosomal protein S6 by activated S6K1

hasComponent

40S ribosomal complex [cytosol]

Other forms of this molecule

RPS6 [nucleoplasm]

p-5S-RPS6 [cytosol]

Inferred To

Ghost homologue of RPS6 [cytosol] (Gallus gallus)

RPS6A [cytosol] (Saccharomyces cerevisiae)

rps602 [cytosol] (Schizosaccharomyces pombe)

RPS6 [cytosol] (Bos taurus)

RPS6 [cytosol] (Canis familiaris)

RPS6 [cytosol] (Plasmodium falciparum)

RPS6 [cytosol] (Sus scrofa)

Homologues of RPS6 [cytosol] (Bos taurus)

Homologues of RPS6 [cytosol] (Saccharomyces cerevisiae)

RPS6B [cytosol] (Saccharomyces cerevisiae)

rps6 [cytosol] (Danio rerio)

rps6 [cytosol] (Dictyostelium discoideum)

rps6 [cytosol] (Xenopus tropicalis)

RpS6 [cytosol] (Drosophila melanogaster)

rps-6 [cytosol] (Caenorhabditis elegans)

Rps6 [cytosol] (Mus musculus)

Rps6 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001001.2

OpenTargets

ENSG00000137154

GeneCards

P62753

HPA

ENSG00000137154-RPS6

Ensembl

ENST00000380394, ENSP00000369757, ENSG00000137154

PRO

P62753

PDB

6G53, 6Y57, 6G4W, 5LKS, 6G51, 5T2C, 6OM0, 6G4S, 6QZP, 6FEC, 6OLE, 6OLZ, 5OA3, 6F4Q, 6F4P, 6Y2L, 4UG0, 5AJ0, 6Y0G, 6OLI, 6G5I, 6OLG, 6IP8, 5FLX, 5A2Q, 6G5H, 6IP5, 6IP6, 6EK0, 6OM7, 4V6X, 5VYC, 6G18, 6OLF, 6ZOJ

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95793 STAU1			0.714	5
UniProt:P06748 NPM1	5	p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [cytosol] (R-HSA-3008211) NPM1 [nucleoplasm] (R-HSA-606320) SUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) SUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.669	3
UniProt:Q14684 RRP1B			0.597	3
UniProt:Q09161 NCBP1	2	NCBP1 [cytosol] (R-HSA-162459) NCBP1 [nucleoplasm] (R-HSA-51469)	0.576	3
UniProt:Q96RG2 PASK			0.558	3
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	3
UniProt:Q15397 PUM3			0.527	2
UniProt:O00567 NOP56	2	NOP56 [cytosol] (R-HSA-391293) NOP56 [nucleoplasm] (R-HSA-6790696)	0.527	2
UniProt:Q5C9Z4 NOM1			0.527	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.527	2
UniProt:P82650 MRPS22	1	MRPS22 [mitochondrial inner membrane] (R-HSA-5368259)	0.462	2
UniProt:P61254 RPL26	1	RPL26 [cytosol] (R-HSA-72436)	0.462	2
UniProt:P82675 MRPS5	1	MRPS5 [mitochondrial inner membrane] (R-HSA-5368176)	0.462	2
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.462	2
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.462	2
UniProt:Q7L2E3 DHX30			0.462	2
UniProt:P82930 MRPS34	1	MRPS34 [mitochondrial inner membrane] (R-HSA-5368186)	0.462	2
UniProt:Q00005 2ABB			0.462	2
UniProt:Q8N9T8 KRI1			0.462	2
UniProt:Q9BRP8 PYM1			0.462	2
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.462	2
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.462	2
UniProt:Q9P2E9 RRBP1			0.462	2
UniProt:Q5JTH9 RRP12			0.462	2
UniProt:P82914 MRPS15	1	MRPS15 [mitochondrial inner membrane] (R-HSA-5368166)	0.462	2
UniProt:Q9BZE4 NOG1			0.462	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.462	2
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.462	2
UniProt:P82663 MRPS25	1	MRPS25 [mitochondrial inner membrane] (R-HSA-5368204)	0.462	2
UniProt:Q9UNX3 RPL26L1	1	RPL26L1 [cytosol] (R-HSA-72438)	0.462	2
UniProt:Q9Y3B7 MRPL11	1	MRPL11 [mitochondrial inner membrane] (R-HSA-5368251)	0.462	2
UniProt:P62753 RPS6	3	p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [nucleoplasm] (R-HSA-6790606) RPS6 [cytosol] (R-HSA-72381)	0.462	2
UniProt:P62891 RPL39	1	RPL39 [cytosol] (R-HSA-72472)	0.462	2
UniProt:Q8TDN6 BRX1			0.462	2
UniProt:Q5SSJ5 HP1B3			0.462	2
UniProt:P51398 DAP3	1	DAP3 [mitochondrial inner membrane] (R-HSA-5368174)	0.462	2
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.462	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.462	2
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.462	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:Q14137 BOP1	1	BOP1 [nucleoplasm] (R-HSA-6791206)	0.462	2

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