Reactome | RPS6 [cytosol]

RPS6 [cytosol]

Stable Identifier

R-HSA-72381

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 6, P10660, 40S ribosomal protein S6, Phosphoprotein NP33

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Influenza Infection (Homo sapiens)
    - Influenza Life Cycle (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62753 RPS6

Gene Names

RPS6, OK/SW-cl.2

Chain

chain:1-249

Reference Genes

BioGPS Gene:6194 RPS6

COSMIC (genes):RPS6 RPS6

CTD Gene:6194 RPS6

dbSNP Gene:6194 RPS6

ENSEMBL:ENSG00000137154 RPS6

ENSEMBL_homo_sapiens_GENE:ENSG00000137154 RPS6

HGNC:10429 RPS6

KEGG Gene (Homo sapiens):6194 RPS6

Monarch:6194 RPS6

NCBI Gene:6194 RPS6

OMIM:180460 RPS6

UCSC:P62753 RPS6

Reference Transcript

RefSeq:NM_001010.2 RPS6

Other Identifiers

0005700403

11719464_x_at

11763007_x_at

17092737

18670421

18670422

18670423

18670425

18670426

18670429

18670432

200081_PM_s_at

200081_s_at

201254_x_at

209134_s_at

31153

3200714

3200715

3200716

3200718

3200719

3200724

3200725

3200726

3200728

3200733

35125_at

3822012

4012811

4027

4UG0

4V6X

5A2Q

5AJ0

5FLX

5LKS

5OA3

5T2C

5VYC

6194

6EK0

6F4P

6F4Q

6FEC

6G18

6G4S

6G4W

6G51

6G53

6G5H

6G5I

8160308

91667_at

A2A3R5

A2A3R7

A_23_P123563

AAA60287

AAA60288

AAA60289

AAH00524

AAH09427

AAH27620

AAH71907

AAH71908

AAH94826

AB062123

BAB93455

BC000524

BC009427

BC027620

BC071907

BC071908

BC094826

CAA47719

CAB004027

CCDS6492

ENSG00000137154

ENSP00000369757

ENST00000380394

EntrezGene:6194

g12751054_3p_s_at

GO:0000003

GO:0000082

GO:0000184

GO:0000278

GO:0001890

GO:0002309

GO:0002376

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005844

GO:0006364

GO:0006412

GO:0006413

GO:0006605

GO:0006614

GO:0006810

GO:0006924

GO:0007049

GO:0007093

GO:0007165

GO:0007369

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0009790

GO:0015935

GO:0016020

GO:0019899

GO:0019901

GO:0022605

GO:0022627

GO:0030154

GO:0030425

GO:0031929

GO:0032991

GO:0033077

GO:0034641

GO:0034655

GO:0036464

GO:0042254

GO:0042274

GO:0042592

GO:0042593

GO:0043065

GO:0043066

GO:0043226

GO:0044297

GO:0048471

GO:0048821

GO:0048856

GO:1990904

HGNC:10429

HPA031153

ILMN_1656791

ILMN_1808939

IPR001377

IPR014401

IPR018282

J03537

M20020

M77232

M77232_rna1_at

MIM:180460

NM_001010

NP_001001

PF01092

PH_hs_0030081

PH_hs_0039702

RPS6

RPS6-204

SM01405

TC09000936.hg

TC09000938.hg

uc003znv.2

UPI00000018E3

X67309

Participant Of

input

Phosphorylation of Ribosomal protein S6 by activated S6K1

hasComponent

40S ribosomal complex [cytosol]

Other forms of this molecule

p-5S-RPS6 [cytosol]

RPS6 [nucleoplasm]

Inferred To

Ghost homologue of RPS6 [cytosol] (Canis familiaris)

Ghost homologue of RPS6 [cytosol] (Mus musculus)

RPS6 [cytosol] (Arabidopsis thaliana)

RPS6 [cytosol] (Bos taurus)

RPS6 [cytosol] (Caenorhabditis elegans)

RPS6 [cytosol] (Danio rerio)

RPS6 [cytosol] (Dictyostelium discoideum)

RPS6 [cytosol] (Drosophila melanogaster)

RPS6 [cytosol] (Gallus gallus)

RPS6 [cytosol] (Oryza sativa)

RPS6 [cytosol] (Plasmodium falciparum)

RPS6 [cytosol] (Rattus norvegicus)

RPS6 [cytosol] (Saccharomyces cerevisiae)

RPS6 [cytosol] (Schizosaccharomyces pombe)

RPS6 [cytosol] (Sus scrofa)

RPS6 [cytosol] (Taeniopygia guttata)

RPS6 [cytosol] (Xenopus tropicalis)

Homologues of RPS6 [cytosol] (Arabidopsis thaliana)

Homologues of RPS6 [cytosol] (Bos taurus)

Homologues of RPS6 [cytosol] (Gallus gallus)

Homologues of RPS6 [cytosol] (Oryza sativa)

Homologues of RPS6 [cytosol] (Saccharomyces cerevisiae)

Homologues of RPS6 [cytosol] (Schizosaccharomyces pombe)

Homologues of RPS6 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001001.2

OpenTargets

ENSG00000137154

GeneCards

P62753

PRO

P62753

PDB

4V6X, 5VYC, 6G5I, 6FEC, 6G53, 5AJ0, 5T2C, 6G5H, 5LKS, 6G51, 6G4W, 6F4Q, 5OA3, 5A2Q, 5FLX, 6F4P, 6G4S, 6G18, 6EK0, 4UG0

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95793 STAU1			0.714	5
UniProt:P06748 NPM1	5	p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [cytosol] (R-HSA-3008211) NPM1 [nucleoplasm] (R-HSA-606320) SUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) SUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.669	3
UniProt:Q14684 RRP1B			0.597	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.576	3
UniProt:Q96RG2 PASK			0.558	3
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	3
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.527	2
UniProt:O00567 NOP56	2	NOP56 [cytosol] (R-HSA-391293) NOP56 [nucleoplasm] (R-HSA-6790696)	0.527	2
UniProt:Q5C9Z4 NOM1			0.527	2
UniProt:P82650 MRPS22	1	MRPS22 [mitochondrial inner membrane] (R-HSA-5368259)	0.462	2
UniProt:P61254 RPL26	1	RPL26 [cytosol] (R-HSA-72436)	0.462	2
UniProt:P82675 MRPS5	1	MRPS5 [mitochondrial inner membrane] (R-HSA-5368176)	0.462	2
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.462	2
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.462	2
UniProt:Q7L2E3 DHX30			0.462	2
UniProt:P82930 MRPS34	1	MRPS34 [mitochondrial inner membrane] (R-HSA-5368186)	0.462	2
UniProt:P03372 ESR1	4	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:Q00005 2ABB			0.462	2
UniProt:Q8N9T8 KRI1			0.462	2
UniProt:Q9BRP8 PYM1			0.462	2
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.462	2
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.462	2
UniProt:Q9P2E9 RRBP1			0.462	2
UniProt:Q5JTH9 RRP12			0.462	2
UniProt:P82914 MRPS15	1	MRPS15 [mitochondrial inner membrane] (R-HSA-5368166)	0.462	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.462	2
UniProt:Q9BZE4 NOG1			0.462	2
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.462	2
UniProt:P82663 MRPS25	1	MRPS25 [mitochondrial inner membrane] (R-HSA-5368204)	0.462	2
UniProt:Q9UNX3 RPL26L1	1	RPL26L1 [cytosol] (R-HSA-72438)	0.462	2
UniProt:Q9Y3B7 MRPL11	1	MRPL11 [mitochondrial inner membrane] (R-HSA-5368251)	0.462	2
UniProt:P62753 RPS6	3	p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381) RPS6 [nucleoplasm] (R-HSA-6790606)	0.462	2
UniProt:P62891 RPL39	1	RPL39 [cytosol] (R-HSA-72472)	0.462	2
UniProt:Q8TDN6 BRX1			0.462	2
UniProt:Q5SSJ5 HP1B3			0.462	2
UniProt:P51398 DAP3	1	DAP3 [mitochondrial inner membrane] (R-HSA-5368174)	0.462	2
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.462	2
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.462	2
UniProt:Q14137 BOP1	1	BOP1 [nucleoplasm] (R-HSA-6791206)	0.462	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.462	2