Reactome | MLEC [specific granule membrane]

MLEC [specific granule membrane]

Stable Identifier

R-HSA-6799618

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule membrane

Synonyms

Malectin, MLEC_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14165 MLEC

Gene Names

MLEC, KIAA0152

Chain

signal peptide:1-28, chain:29-292

Reference Genes

BioGPS Gene:9761 MLEC

COSMIC (genes):MLEC MLEC

CTD Gene:9761 MLEC

dbSNP Gene:9761 MLEC

ENSEMBL:ENSG00000110917 MLEC

HGNC:28973 MLEC

KEGG:hsa:9761 MLEC

Monarch:9761 MLEC

NCBI Gene:9761 MLEC

OMIM:613802 MLEC

UCSC:Q14165 MLEC

Reference Transcript

RefSeq:NM_014730.3 MLEC

Other Identifiers

11715518_a_at

11715519_a_at

11715520_at

11715521_a_at

16757969

200616_PM_s_at

200616_s_at

200617_PM_at

200617_at

243545_PM_at

243545_at

3434528

3434529

3434530

3434531

3434537

3434538

3434539

3434541

3434542

3434543

3434544

3434545

3434546

3434547

3434548

3434549

3434550

3434551

3434553

3434555

3434557

3434559

3434561

3434563

3434564

3434577

41728_at

7959205

9761

A_14_P110817

A_23_P2554

A_24_P304449

D63486_at

GE62497

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0006486

GO:0006487

GO:0008250

GO:0016020

GO:0019899

GO:0030246

GO:0035579

GO:0043226

HMNXSV003032241

HMNXSV003034664

Hs.201789.0.A1_3p_at

ILMN_1657495

PH_hs_0010734

TC12000949.hg

g12653206_3p_a_at

g7661947_3p_at

Participates

as a member of

Specific granule membrane proteins [specific granule membrane] (Homo sapiens)

Other forms of this molecule

MLEC [endoplasmic reticulum membrane]

MLEC [plasma membrane]

Inferred To

mlec [specific granule membrane] (Xenopus tropicalis)

Dmel\CG9257 [specific granule membrane] (Drosophila melanogaster)

MLEC [specific granule membrane] (Bos taurus)

MLEC [specific granule membrane] (Caenorhabditis elegans)

MLEC [specific granule membrane] (Canis familiaris)

MLEC [specific granule membrane] (Danio rerio)

MLEC [specific granule membrane] (Gallus gallus)

MLEC [specific granule membrane] (Mus musculus)

MLEC [specific granule membrane] (Rattus norvegicus)

MLEC [specific granule membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000228506, ENST00000228506

OpenTargets

ENSG00000110917

HPA

ENSG00000110917-MLEC

PRO

Q14165

Pharos - Targets

Q14165

GlyGen

Q14165

PDB

6S7T

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.744	4
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.688	3
UniProt:Q8TCJ2 STT3B	1	STT3B [endoplasmic reticulum membrane] (R-HSA-264930)	0.657	3
UniProt:P39656 DDOST	3	DDOST [plasma membrane] (R-HSA-879386) DDOST [azurophil granule membrane] (R-HSA-6799145) DDOST [endoplasmic reticulum membrane] (R-HSA-264963)	0.564	2
UniProt:P61803 DAD1	1	DAD1 [endoplasmic reticulum membrane] (R-HSA-265089)	0.528	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9

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