Reactome | AHCY [cytosol]

AHCY [cytosol]

Stable Identifier

R-HSA-174373

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SAH hydrolase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P23526 AHCY

Gene Names

AHCY, SAHH

Chain

initiator methionine:, chain:2-432

Reference Genes

BioGPS Gene:191 AHCY

COSMIC (genes):AHCY AHCY

CTD Gene:191 AHCY

dbSNP Gene:191 AHCY

ENSEMBL:ENSG00000101444 AHCY

ENSEMBL_homo_sapiens_GENE:ENSG00000101444.13 AHCY

HGNC:343 AHCY

KEGG Gene (Homo sapiens):191 AHCY

Monarch:191 AHCY

NCBI Gene:191 AHCY

OMIM:180960 AHCY

UCSC:P23526 AHCY

Reference Transcript

Other Identifiers

11730199_a_at

11745929_a_at

11747783_x_at

16918496

191

200903_PM_s_at

200903_s_at

3903377

3903378

3903379

3903380

3903381

3903382

3903383

3903385

3903386

3903387

3903388

3903390

3903391

3903392

3903393

3903398

3903399

3903401

40821_at

8065738

A_23_P17575

A_24_P57367

GE58009

GO:0003824

GO:0004013

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005783

GO:0005829

GO:0006730

GO:0006790

GO:0016787

GO:0031410

GO:0033353

GO:0042470

GO:0043226

GO:0070062

HMNXSV003033859

ILMN_1657862

M61832_s_at

PH_hs_0024442

TC20000780.hg

g9951914_3p_a_at

Participates

as a component of

AHCY:NAD+ [cytosol] (Homo sapiens)

Other forms of this molecule

AHCY Y143C [cytosol]

AHCY W112* [cytosol]

Inferred To

AHCY [cytosol] (Bos taurus)

AHCY [cytosol] (Caenorhabditis elegans)

AHCY [cytosol] (Canis familiaris)

AHCY [cytosol] (Danio rerio)

AHCY [cytosol] (Dictyostelium discoideum)

AHCY [cytosol] (Drosophila melanogaster)

AHCY [cytosol] (Gallus gallus)

AHCY [cytosol] (Mus musculus)

AHCY [cytosol] (Saccharomyces cerevisiae)

AHCY [cytosol] (Schizosaccharomyces pombe)

AHCY [cytosol] (Sus scrofa)

AHCY [cytosol] (Xenopus tropicalis)

Ahcy [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_011526961.1, NP_001155238.1, XP_016883198.1, XP_005260374.1, NP_000678.1, XP_016883197.1, NP_001309013.1, NP_001309014.1

Guide to Pharmacology - Targets

1233

OpenTargets

ENSG00000101444

ZINC - Substances

SAHH_HUMAN

ZINC target

P23526

PRO

P23526

PDB

1A7A, 5W4B, 5W49, 4PGF, 1LI4, 3NJ4, 4PFJ, 4YVF

HPA

ENSG00000101444-AHCY

GeneCards

P23526

Ensembl

ENSP00000217426, ENSG00000101444, ENST00000217426, ENSP00000442820, ENST00000538132

Pharos - Targets

P23526

ZINC - Predictions - Purchasable

SAHH_HUMAN

Orphanet

15477

HMDB Protein

HMDBP00662

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BV19 CA050			0.923	13
UniProt:Q6AI12 ANR40			0.905	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	15
UniProt:Q92624 APBP2			0.556	3
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.547	2
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.527	2
UniProt:Q9Q2G4 Q9Q2G4			0.462	2

Cite Us!