Reactome | PPP6R3 [cytosol]

PPP6R3 [cytosol]

Stable Identifier

R-HSA-5685722

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        PP6 dephosphorylates SEC24 (Homo sapiens)
        
        PP6 [cytosol] (Homo sapiens)
        
        PPP6R1,3 [cytosol] (Homo sapiens)
        
        PPP6R3 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - PP6 dephosphorylates SEC24 (Homo sapiens)
        
        PP6 [cytosol] (Homo sapiens)
        
        PPP6R1,3 [cytosol] (Homo sapiens)
        
        PPP6R3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5H9R7 PPP6R3

Gene Names

PPP6R3, C11orf23, KIAA1558, PP6R3, SAPL, SAPS3

Chain

chain:1-873

Reference Genes

BioGPS Gene:55291 PPP6R3

COSMIC (genes):PPP6R3 PPP6R3

CTD Gene:55291 PPP6R3

dbSNP Gene:55291 PPP6R3

ENSEMBL:ENSG00000110075 PPP6R3

HGNC:1173 PPP6R3

KEGG:hsa:55291 PPP6R3

Monarch:55291 PPP6R3

NCBI Entrez Gene:55291 PPP6R3

OMIM:610879 PPP6R3

UCSC:Q5H9R7 PPP6R3

Reference Transcript

Other Identifiers

11749900_a_at

3337635

3337636

3337640

3337646

3337647

3337648

3337662

3337663

3337664

3337667

3337668

3337669

3337670

3337673

3337677

3337678

3337679

3337682

3337694

3337698

3337699

3337700

3337701

3337702

3337718

55291

67715_s_at

72109_at

A_14_P110692

A_14_P112561

A_14_P121979

A_23_P150129

A_23_P202637

A_33_P3445805

GE61228

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006516

GO:0009966

GO:0019888

GO:0019903

GO:0030163

GO:1901135

HMNXSV003024590

HMNXSV003037793

HMNXSV003039830

ILMN_1732725

PH_hs_0022410

Participates

as a member of

PPP6R1,3 [cytosol] (Homo sapiens)

Other forms of this molecule

PPP6R3 [nucleoplasm]

Inferred To

SAP190 [cytosol] (Saccharomyces cerevisiae)

ppp6r3 [cytosol] (Xenopus tropicalis)

Ppp6r3 [cytosol] (Mus musculus)

Ppp6r3 [cytosol] (Rattus norvegicus)

PPP6R3 [cytosol] (Bos taurus)

PPP6R3 [cytosol] (Canis familiaris)

PPP6R3 [cytosol] (Dictyostelium discoideum)

PPP6R3 [cytosol] (Gallus gallus)

PPP6R3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001157636.1, NP_001157635.1, XP_047283164.1, XP_047283163.1, NP_001339304.1, NP_001157632.1, XP_054225248.1, XP_016873455.1, XP_047283162.1, XP_047283160.1, NP_001157633.1, NP_001157634.1, XP_047283161.1, XP_006718687.1, XP_011543442.1, XP_054225262.1, XP_047283174.1, XP_054225236.1, XP_054225235.1, XP_006718681.1, XP_054225233.1, XP_054225234.1, NP_001339292.1, NP_001339293.1, NP_001339297.1, XP_006718677.1, XP_006718676.1, XP_054225232.1, XP_016873451.1, XP_016873452.1, NP_001339308.1, NP_001339277.1, NP_060782.2, XP_054225237.1

OpenTargets

ENSG00000110075

ENSEMBL

ENST00000524904, ENSP00000265636, ENST00000524845, ENST00000265636, ENSP00000431415, ENSG00000110075, ENST00000393800, ENST00000529710, ENSP00000377389, ENSP00000433058, ENSP00000437329, ENSP00000377390, ENST00000393801

HPA

ENSG00000110075-PPP6R3

GeneCards

PPP6R3

PRO

Q5H9R7

Pharos - Targets

Q5H9R7

GlyGen

Q5H9R7

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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