Reactome | PPP6R3 [cytosol]

PPP6R3 [cytosol]

Stable Identifier

R-HSA-5685722

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        PP6 dephosphorylates SEC24 (Homo sapiens)
        
        PP6 [cytosol] (Homo sapiens)
        
        PPP6R1,3 [cytosol] (Homo sapiens)
        
        PPP6R3 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - PP6 dephosphorylates SEC24 (Homo sapiens)
        
        PP6 [cytosol] (Homo sapiens)
        
        PPP6R1,3 [cytosol] (Homo sapiens)
        
        PPP6R3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5H9R7 PPP6R3

Gene Names

PPP6R3, C11orf23, KIAA1558, PP6R3, SAPL, SAPS3

Chain

chain:1-873

Reference Genes

BioGPS Gene:55291 PPP6R3

COSMIC (genes):PPP6R3 PPP6R3

CTD Gene:55291 PPP6R3

dbSNP Gene:55291 PPP6R3

ENSEMBL:ENSG00000110075 PPP6R3

HGNC:1173 PPP6R3

KEGG:hsa:55291 PPP6R3

Monarch:55291 PPP6R3

NCBI Gene:55291 PPP6R3

OMIM:610879 PPP6R3

UCSC:Q5H9R7 PPP6R3

Reference Transcript

Other Identifiers

11724027_s_at

11745849_a_at

11749900_a_at

11752108_a_at

16728095

217928_PM_s_at

217928_s_at

222467_PM_s_at

222467_s_at

3337619

3337636

3337640

3337641

3337646

3337647

3337648

3337650

3337656

3337658

3337659

3337662

3337663

3337664

3337667

3337668

3337669

3337670

3337673

3337677

3337678

3337679

3337680

3337681

3337682

3337683

3337684

3337685

3337686

3337689

3337694

3337698

3337699

3337700

3337701

3337702

3337703

3337704

3337705

3337706

3337709

3337711

3337714

3337718

3337719

3337720

3337723

3337724

3337725

3337726

3337727

3337728

3337729

45247_at

55291

67715_s_at

72109_at

77863_s_at

77865_at

7942032

81396_at

A_14_P110692

A_14_P112561

A_14_P121979

A_23_P150129

A_23_P202637

A_24_P261488

A_33_P3445805

GE61228

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006516

GO:0019888

GO:0019903

GO:0030163

GO:0043226

GO:0043666

GO:0098772

GO:1901135

HMNXSV003024590

HMNXSV003037793

HMNXSV003039830

Hs.180817.0.S1_3p_a_at

ILMN_1732725

PH_hs_0022410

TC11000708.hg

TC11002748.hg

g13489082_3p_a_at

Participates

as a member of

PPP6R1,3 [cytosol] (Homo sapiens)

Other forms of this molecule

PPP6R3 [nucleoplasm]

Inferred To

SAP190 [cytosol] (Saccharomyces cerevisiae)

ppp6r3 [cytosol] (Xenopus tropicalis)

Ppp6r3 [cytosol] (Mus musculus)

Ppp6r3 [cytosol] (Rattus norvegicus)

PPP6R3 [cytosol] (Bos taurus)

PPP6R3 [cytosol] (Canis familiaris)

PPP6R3 [cytosol] (Dictyostelium discoideum)

PPP6R3 [cytosol] (Gallus gallus)

PPP6R3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_060782.2, XP_006718676.1, XP_016873451.1, XP_006718677.1, XP_006718687.1, XP_016873452.1, XP_016873455.1, XP_011543442.1, NP_001157632.1, XP_006718681.1, NP_001157634.1, NP_001157633.1, NP_001157635.1, NP_001157636.1

OpenTargets

ENSG00000110075

ENSEMBL

ENST00000393801, ENST00000529710, ENSP00000377389, ENST00000524904, ENSP00000265636, ENSP00000433058, ENSP00000377390, ENSP00000431415, ENSP00000437329, ENST00000524845, ENST00000265636, ENST00000393800

HPA

ENSG00000110075-PPP6R3

PRO

Q5H9R7

Pharos - Targets

Q5H9R7

GlyGen

Q5H9R7

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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