Reactome | VDAC1 [mitochondrial outer membrane]

VDAC1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-1267988

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Voltage-dependent anion-selective channel protein 1, VDAC1_HUMAN

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External Reference Information

External Reference

UniProt:P21796 VDAC1

Gene Names

VDAC1, VDAC

Chain

initiator methionine:, chain:2-283

Reference Genes

BioGPS Gene:7416 VDAC1

COSMIC (genes):VDAC1 VDAC1

CTD Gene:7416 VDAC1

dbSNP Gene:7416 VDAC1

ENSEMBL:ENSG00000213585 VDAC1

HGNC:12669 VDAC1

KEGG:hsa:7416 VDAC1

Monarch:7416 VDAC1

NCBI Gene:7416 VDAC1

OMIM:604492 VDAC1

UCSC:P21796 VDAC1

Reference Transcript

Other Identifiers

11715655_s_at

16999985

212038_PM_s_at

212038_s_at

217140_PM_s_at

217140_s_at

2370085

2683588

2875955

2875956

2875957

2875958

2875959

2875960

2875961

2875962

2875963

2875964

2875965

2875966

2875967

2875968

2875972

2875974

2875978

2875980

31608_g_at

3456919

3982776

3982780

3982781

4008064

4008066

4008075

4008077

4014643

40198_at

4033601

49354_at

7416

8114145

A_23_P144816

GE57563

GO:0001662

GO:0005215

GO:0005515

GO:0005524

GO:0005634

GO:0005739

GO:0005741

GO:0005757

GO:0005886

GO:0006090

GO:0006811

GO:0006820

GO:0006869

GO:0006915

GO:0007268

GO:0007270

GO:0007612

GO:0008142

GO:0008289

GO:0008308

GO:0012501

GO:0015288

GO:0015485

GO:0016020

GO:0019901

GO:0023052

GO:0030154

GO:0030855

GO:0031210

GO:0031966

GO:0036444

GO:0042645

GO:0042802

GO:0043065

GO:0043066

GO:0043226

GO:0043227

GO:0044325

GO:0045121

GO:0045202

GO:0046930

GO:0050877

GO:0055085

GO:0070062

GO:0097001

GO:0098656

GO:0110099

GO:1901524

GO:1903146

GO:1905091

GO:1990542

GO:2000378

HMNXSV003020379

Hs.149155.2.A1_3p_a_at

ILMN_2175601

L06132_at

PH_hs_0030040

TC05001785.hg

TC05003242.hg

p33706

Participates

as a candidate of

as a member of

VDAC1,2,3 [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

p-S65-Ub:VDAC1 [mitochondrial outer membrane]

K63polyUb-VDAC1 [mitochondrial outer membrane]

K48polyUb-VDAC1 [mitochondrial outer membrane]

Ub-VDAC1 [mitochondrial outer membrane]

VDAC1 [mitochondrial intermembrane space]

PolyUb-VDAC1 [mitochondrial outer membrane]

Inferred To

Porin2 [mitochondrial outer membrane] (Drosophila melanogaster)

vdac1 [mitochondrial outer membrane] (Danio rerio)

vdac1 [mitochondrial outer membrane] (Xenopus tropicalis)

VDAC1 [mitochondrial outer membrane] (Bos taurus)

VDAC1 [mitochondrial outer membrane] (Canis familiaris)

VDAC1 [mitochondrial outer membrane] (Gallus gallus)

VDAC1 [mitochondrial outer membrane] (Mus musculus)

VDAC1 [mitochondrial outer membrane] (Plasmodium falciparum)

VDAC1 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

VDAC1 [mitochondrial outer membrane] (Schizosaccharomyces pombe)

VDAC1 [mitochondrial outer membrane] (Sus scrofa)

vdac-1 [mitochondrial outer membrane] (Caenorhabditis elegans)

POR1 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

CG31722 [mitochondrial outer membrane] (Drosophila melanogaster)

CG31722-B [mitochondrial outer membrane] (Drosophila melanogaster)

porA [mitochondrial outer membrane] (Dictyostelium discoideum)

porin [mitochondrial outer membrane] (Drosophila melanogaster)

Vdac1 [mitochondrial outer membrane] (Rattus norvegicus)

Homologues of VDAC1 [mitochondrial outer membrane] (Drosophila melanogaster)

Homologues of VDAC1 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_005272132.1, NP_003365.1, XP_016865310.1, XP_016865311.1, XP_016865312.1

OpenTargets

ENSG00000213585

ENSEMBL

ENSP00000265333, ENSP00000378484, ENSP00000378487, ENST00000265333, ENST00000395047, ENST00000395044

HPA

ENSG00000213585-VDAC1

PRO

P21796

Pharos - Targets

P21796

GlyGen

P21796

HMDB Protein

HMDBP02507

PDB

2K4T, 5JDP, 6G6U, 6TIQ, 6TIR, 2JK4, 5XDO, 5XDN, 6G73, 7QI2, 8J0O

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y277 VDAC3	5	PolyUb-VDAC3 [mitochondrial outer membrane] (R-HSA-6783045) VDAC3 [mitochondrial outer membrane] (R-HSA-5696901) Ub-VDAC3 [mitochondrial outer membrane] (R-HSA-9835015) K63polyUb-VDAC3 [mitochondrial outer membrane] (R-HSA-9843310) p-S65-Ub:VDAC3 [mitochondrial outer membrane] (R-HSA-9835016)	0.669	4
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.655	4
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.623	6
UniProt:P0C0U1 PB1	2	PB1-F2 [mitochondrial intermembrane space] (R-FLU-5146789) PB1-F2 [cytosol] (R-FLU-169216)	0.591	4
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.589	2
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.576	3
UniProt:P19367 HK1	4	HK1 [cytosol] (R-HSA-70395) HK1 L529S [cytosol] (R-HSA-5621861) HK1 H577_C672del [cytosol] (R-HSA-5621873) HK1 T680S [cytosol] (R-HSA-5621880)	0.564	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.564	3
UniProt:P81605 DCD	4	DCD(20-62) [extracellular region] (R-HSA-6802986) DCD(20-110) [extracellular region] (R-HSA-6802997) DCD(63-110) [extracellular region] (R-HSA-6802991) DCD(63-109) [extracellular region] (R-HSA-6801811)	0.564	2
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374) SLC25A6 [mitochondrial inner membrane] (R-HSA-49745)	0.564	4
UniProt:P06753 TPM3	3	TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710848) TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710837) TPM3 [cytosol] (R-HSA-390543)	0.564	4
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.544	2
UniProt:Q07813	2	Bax [cytosol] (R-MMU-139907) Bax [mitochondrial outer membrane] (R-MMU-139949)	0.544	2
UniProt:Q7L3V2 BOP			0.544	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.527	3
UniProt:P51149 RAB7A	7	RAB7A [secretory granule membrane] (R-HSA-6804969) RAB7A [plasma membrane] (R-HSA-6804990) RAB7A [cytosol] (R-HSA-8870415) RAB7A [phagocytic vesicle membrane] (R-HSA-9636586) RAB7A [lysosomal membrane] (R-HSA-2213231) GGC-RAB7A [cytosol] (R-HSA-8870438) GGC-RAB7A [lysosomal membrane] (R-HSA-8877454)	0.527	2
UniProt:P0DTD1-PRO_0000449624 REP			0.527	2
UniProt:P61019 RAB2A	3	GGC-RAB2A [cytosol] (R-HSA-8873963) RAB2A [cytosol] (R-HSA-8873716) RAB2A [Golgi membrane] (R-HSA-2422386)	0.527	2
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960)	0.508	2
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.499	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.499	5
UniProt:P30041 PRDX6	3	PRDX6 [cytosol] (R-HSA-3343670) PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [azurophil granule lumen] (R-HSA-6798744)	0.499	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5
UniProt:Q9H9B4 SFXN1			0.483	4
UniProt:P12956 XRCC6	5	XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300)	0.483	3
UniProt:P04578-PRO_0000038428 ENV			0.462	2

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