Reactome | HSPA2 [cytosol]

HSPA2 [cytosol]

Stable Identifier

R-HSA-3371408

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Heat shock-related 70 kDa protein 2, HSP72_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
      - PKR-mediated signaling (Homo sapiens)
        
        FA core complex:HSP70s binds PKR (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        HSP70 proteins [cytosol] (Homo sapiens)
        
        HSPA2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        HSP70 proteins [cytosol] (Homo sapiens)
        
        HSPA2 [cytosol] (Homo sapiens)
        
        PKR forms a dimer (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        HSP70 proteins [cytosol] (Homo sapiens)
        
        HSPA2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54652 HSPA2

Gene Names

HSPA2

Chain

chain:1-639

Reference Genes

BioGPS Gene:3306 HSPA2

COSMIC (genes):HSPA2 HSPA2

CTD Gene:3306 HSPA2

dbSNP Gene:3306 HSPA2

ENSEMBL:ENSG00000126803 HSPA2

ENSEMBL:ENSG00000126803.10 HSPA2

HGNC:5235 HSPA2

KEGG Gene (Homo sapiens):3306 HSPA2

Monarch:3306 HSPA2

NCBI Gene:3306 HSPA2

OMIM:140560 HSPA2

UCSC:P54652 HSPA2

Reference Transcript

RefSeq:NM_021979.3 HSPA2

Other Identifiers

11724723_a_at

16785379

211538_PM_s_at

211538_s_at

2363790

3306

3540137

3540138

3540139

3540140

3540141

3540142

3540143

3540144

3540145

3540146

3540147

3540148

3540156

3540157

3540158

36925_at

645_at

7975076

A_14_P200378

A_23_P88303

GE59248

GO:0000166

GO:0000228

GO:0000278

GO:0000795

GO:0001673

GO:0001934

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0006457

GO:0006986

GO:0007140

GO:0007141

GO:0007283

GO:0007286

GO:0008092

GO:0008289

GO:0009408

GO:0009409

GO:0009986

GO:0010971

GO:0016020

GO:0016787

GO:0016887

GO:0019899

GO:0022414

GO:0030154

GO:0031072

GO:0032781

GO:0036128

GO:0036211

GO:0042026

GO:0043226

GO:0044183

GO:0048156

GO:0048856

GO:0051082

GO:0051085

GO:0051087

GO:0051861

GO:0055085

GO:0070062

GO:0070194

GO:0072562

GO:0072687

GO:0090084

GO:0097718

GO:0140013

GO:0140657

GO:0140662

GO:1901896

HMNXSV003027503

ILMN_1766499

ILMN_2153916

L26336_at

PH_hs_0020027

TC14000391.hg

g4204879_3p_a_at

Participates

as a component of

as a candidate of

HSP70 proteins [cytosol] (Homo sapiens)

Other forms of this molecule

HSPA2 [nucleoplasm]

Inferred To

hspE-2 [cytosol] (Dictyostelium discoideum)

Hsc70-1 [cytosol] (Drosophila melanogaster)

hsp-1 [cytosol] (Caenorhabditis elegans)

hspB [cytosol] (Dictyostelium discoideum)

Hsc70-4 [cytosol] (Drosophila melanogaster)

HSPA2 [cytosol] (Bos taurus)

HSPA2 [cytosol] (Canis familiaris)

HSPA2 [cytosol] (Dictyostelium discoideum)

HSPA2 [cytosol] (Mus musculus)

HSPA2 [cytosol] (Rattus norvegicus)

HSPA2 [cytosol] (Saccharomyces cerevisiae)

HSPA2 [cytosol] (Schizosaccharomyces pombe)

ssa2 [cytosol] (Schizosaccharomyces pombe)

hspa8 [cytosol] (Danio rerio)

SSA3 [cytosol] (Saccharomyces cerevisiae)

SSA4 [cytosol] (Saccharomyces cerevisiae)

si:dkey-4p15.3 [cytosol] (Danio rerio)

tut7 [cytosol] (Xenopus tropicalis)

ssa1 [cytosol] (Schizosaccharomyces pombe)

SSA1 [cytosol] (Saccharomyces cerevisiae)

Homologues of HSPA2 [cytosol] (Danio rerio)

Homologues of HSPA2 [cytosol] (Dictyostelium discoideum)

Homologues of HSPA2 [cytosol] (Drosophila melanogaster)

Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)

Homologues of HSPA2 [cytosol] (Schizosaccharomyces pombe)

SSA2 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_068814.2

Guide to Pharmacology - Targets

2541

OpenTargets

ENSG00000126803

HPA

ENSG00000126803-HSPA2

GeneCards

P54652

Ensembl

ENSP00000247207, ENSP00000378199, ENST00000394709, ENSG00000126803, ENST00000247207

PRO

P54652

Pharos - Targets

P54652

PDB

5FPM, 4FSV, 5FPE, 3I33, 5FPN, 5FPD

Interactors (63)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZL4 HPBP1			0.801	7
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.703	5
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.666	4
UniProt:Q9NSA1 FGF21	2	FGF21 [cytosol] (R-HSA-6784692) FGF21 [extracellular region] (R-HSA-189909)	0.61	4
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.569	4
UniProt:Q58EX7-2 Q58EX72			0.556	3
UniProt:O60636 TSN2			0.556	3
UniProt:Q9NUC0 SRTD4			0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.556	3
IntAct:EBI-25852558 CCSB			0.556	3
UniProt:Q92782-2 Q927822			0.556	3
UniProt:Q92530 PSMF1	2	PSMF1 [nucleoplasm] (R-HSA-174308) PSMF1 [cytosol] (R-HSA-68818)	0.556	3
UniProt:Q9NX94 WBP1L			0.556	3
UniProt:Q8WUU4 ZN296			0.556	3
UniProt:Q9BRR0 ZKSCAN3	1	ZKSCAN3 [nucleoplasm] (R-HSA-1027422)	0.556	3
UniProt:A0A024RCP2 A0A024RCP2			0.556	3
UniProt:Q9UHI5 SLC7A8	1	SLC7A8 [plasma membrane] (R-HSA-352156)	0.556	3
UniProt:Q96FT7-4 ASIC4			0.556	3
UniProt:P49459 UBE2A	3	UBE2A [cytosol] (R-HSA-947617) Ub-C88-UBE2A [nucleoplasm] (R-HSA-8864186) UBE2A [nucleoplasm] (R-HSA-8852048)	0.556	3
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.556	3
UniProt:Q6DHV7-2 Q6DHV72			0.556	3
UniProt:Q92615 LAR4B			0.556	3
UniProt:P79522 PRR3			0.556	3
UniProt:Q7Z7C8-2 TAF8			0.556	3
UniProt:Q9NNX6-10 CD209			0.556	3
UniProt:Q8N2H9-4 PELI3			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
IntAct:EBI-25835796 CCSB			0.556	3
UniProt:Q5SXH7-1 PLEKHS1			0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q53R41 FAKD1			0.556	3
UniProt:Q9HD47-3 RANGRF			0.556	3
UniProt:Q9Y4F5-3 CEP170B			0.556	3
UniProt:Q15973 ZNF124	1	ZNF124 [nucleoplasm] (R-HSA-975017)	0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:Q66PJ3-4 ARL6IP4			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q8N0U2 TMM61			0.556	3
UniProt:Q14181 POLA2	1	POLA2 [nucleoplasm] (R-HSA-68493)	0.556	3
IntAct:EBI-25835866 CCSB			0.556	3
UniProt:Q6P597 KLC3	1	KLC3 [cytosol] (R-HSA-983232)	0.556	3
UniProt:Q3KNS6-3 Q3KNS63			0.556	3
UniProt:Q9BYN7-2 ZNF341			0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:P30301 MIP	1	MIP [plasma membrane] (R-HSA-432026)	0.556	3
UniProt:P15407 FOSL1	1	FOSL1 [nucleoplasm] (R-HSA-9620405)	0.556	3
UniProt:Q7Z6I5 SPT12			0.556	3
UniProt:Q496A3 SPAS1			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q96EY1-3 DNAJA3			0.556	3
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.556	3
UniProt:Q96MA6 AK8	1	AK8 [cytosol] (R-HSA-6788788)	0.556	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q13562 NEUROD1	1	NEUROD1 [nucleoplasm] (R-HSA-186689)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:Q9H1D9 POLR3F	2	POLR3F [nucleoplasm] (R-HSA-83708) POLR3F [cytosol] (R-HSA-1964434)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	4
UniProt:Q96BE0 Q96BE0			0.499	2

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