Reactome | CD58 [secretory granule membrane]

CD58 [secretory granule membrane]

Stable Identifier

R-HSA-6801294

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Synonyms

Lymphocyte function-associated antigen 3 precursor, LFA3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P19256 CD58

Gene Names

CD58, LFA3

Chain

signal peptide:1-28, chain:29-250

Reference Genes

BioGPS Gene:965 CD58

COSMIC (genes):CD58 CD58

CTD Gene:965 CD58

dbSNP Gene:965 CD58

ENSEMBL:ENSG00000116815 CD58

HGNC:1688 CD58

KEGG:hsa:965 CD58

Monarch:965 CD58

NCBI Gene:965 CD58

OMIM:153420 CD58

UCSC:P19256 CD58

Reference Transcript

Other Identifiers

11724689_a_at

11737835_at

11749610_a_at

11753998_a_at

11753999_s_at

11754000_x_at

16691403

205173_PM_x_at

205173_x_at

211744_PM_s_at

211744_s_at

216942_PM_s_at

216942_s_at

2429851

2429854

2429855

2429858

2429877

2429878

2429882

2429883

37177_at

7918902

965

A_23_P138308

A_33_P3209096

A_33_P3289356

GE60233

GO:0005102

GO:0005515

GO:0005886

GO:0007155

GO:0009986

GO:0016020

GO:0030667

GO:0032757

GO:0034113

GO:0043226

GO:0070062

GO:0071346

GO:0071356

GO:0098609

GO:0101003

HMNXSV003041672

Hs.287995.0.S1_3p_s_at

Hs.75626.2.S1_3p_s_at

ILMN_1785268

ILMN_2147517

PH_hs_0004351

TC01003029.hg

TC01005732.hg

Y00636_at

Participates

as a member of

Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)

Other forms of this molecule

CD58 [plasma membrane]

CD58 [ficolin-1-rich granule membrane]

Inferred To

CD58 [secretory granule membrane] (Bos taurus)

CD58 [secretory granule membrane] (Canis familiaris)

CD58 [secretory granule membrane] (Gallus gallus)

CD58 [secretory granule membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000409080, ENSP00000358501, ENST00000457047, ENST00000464088, ENSP00000432773, ENST00000369489

OpenTargets

ENSG00000116815

HPA

ENSG00000116815-CD58

PRO

P19256

Pharos - Targets

P19256

PDB

1CCZ, 1QA9, 1CI5

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	2

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