Reactome | MARS [cytosol]

MARS [cytosol]

Stable Identifier

R-HSA-379657

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Methionyl-tRNA synthetase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P56192 MARS1

Gene Names

MARS1, MARS

Chain

chain:1-900

Reference Genes

BioGPS Gene:4141 MARS1

COSMIC (genes):MARS MARS1

CTD Gene:4141 MARS1

dbSNP Gene:4141 MARS1

ENSEMBL:ENSG00000166986 MARS

HGNC:6898 MARS1

KEGG:hsa:4141 MARS1

Monarch:4141 MARS1

NCBI Gene:4141 MARS1

OMIM:156560 MARS1

UCSC:P56192 MARS1

Reference Transcript

RefSeq:NM_004990.3 MARS1

Other Identifiers

11744024_a_at

11746637_a_at

11755845_x_at

11763166_a_at

11763167_x_at

16752908

201475_PM_x_at

201475_x_at

213671_PM_s_at

213671_s_at

213672_PM_at

213672_at

3418152

3418154

3418155

3418156

3418157

3418158

3418159

3418160

3418161

3418162

3418163

3418164

3418165

3418166

3418167

3418168

3418169

3418170

3418171

3418172

3418173

3418176

3418177

3418178

3418179

3418180

3418181

3418182

3418183

3418185

3418186

3418187

3418188

3418189

3418190

3418191

3418192

3418193

3418194

3418195

3418196

3418197

3418198

3418199

3418200

3418201

3418202

3418203

3418204

3418205

3418206

3418207

3418208

3418209

3418210

3418211

39342_at

4141

7956443

A_14_P118336

A_14_P127400

A_14_P200351

A_23_P128036

A_24_P175909

A_33_P3379377

GE674307

GE79201

GO:0000049

GO:0000166

GO:0003723

GO:0003824

GO:0004812

GO:0004825

GO:0005524

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006399

GO:0006412

GO:0006418

GO:0006431

GO:0006520

GO:0009303

GO:0016020

GO:0016874

GO:0017101

GO:0036120

GO:0043226

GO:0070062

GO:0071364

GO:0140098

GO:1901838

HMNXSV003000138

HMNXSV003057278

ILMN_1799819

PH_hs_0018937

PH_hs_0023984

RNA147513|p0617_imsncRNA346

TC12000531.hg

X94754_at

g4826825_3p_s_at

Participates

as a component of

Inferred To

MetRS [cytosol] (Drosophila melanogaster)

Mars1 [cytosol] (Rattus norvegicus)

MARS1 [cytosol] (Bos taurus)

MARS1 [cytosol] (Canis familiaris)

MARS1 [cytosol] (Sus scrofa)

MARS [cytosol] (Dictyostelium discoideum)

MARS [cytosol] (Gallus gallus)

MARS [cytosol] (Mus musculus)

Cross References

RefSeq

NP_004981.2

ENSEMBL

ENSP00000262027, ENSP00000446168, ENST00000262027, ENST00000537638

OpenTargets

ENSG00000166986

ZINC - Substances

SYMC_HUMAN

ZINC target

P56192

PRO

P56192

GlyGen

P56192

PDB

4BVX, 2DJV, 4BL7, 4BVY, 5Y6L, 5GOY, 5GL7

IntEnz

6.1.1.10

HPA

ENSG00000166986-MARS1

Pharos - Targets

P56192

Orphanet

MARS1

ZINC - Predictions - Purchasable

SYMC_HUMAN

HMDB Protein

HMDBP00623

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	18
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.527	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3

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