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TKT [cytosol]
Stable Identifier
R-HSA-71321
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
transketolase monomer, TKT_HUMAN, Transketolase , TK
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulates pentose phosphate pathway genes (Homo sapiens)
NFE2L2-dependent TKT gene expression (Homo sapiens)
TKT dimer [cytosol] (Homo sapiens)
TKT [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Insulin effects increased synthesis of Xylulose-5-Phosphate (Homo sapiens)
D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Homo sapiens)
TKT dimer [cytosol] (Homo sapiens)
TKT [cytosol] (Homo sapiens)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Homo sapiens)
TKT dimer [cytosol] (Homo sapiens)
TKT [cytosol] (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Pentose phosphate pathway (Homo sapiens)
D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Homo sapiens)
TKT dimer [cytosol] (Homo sapiens)
TKT [cytosol] (Homo sapiens)
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate (Homo sapiens)
TKT dimer [cytosol] (Homo sapiens)
TKT [cytosol] (Homo sapiens)
ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)
TKT dimer [cytosol] (Homo sapiens)
TKT [cytosol] (Homo sapiens)
xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Homo sapiens)
TKT dimer [cytosol] (Homo sapiens)
TKT [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29401 TKT
Gene Names
TKT
Chain
chain:1-623
Reference Genes
BioGPS Gene:7086 TKT
COSMIC (genes):TKT TKT
CTD Gene:7086 TKT
dbSNP Gene:7086 TKT
ENSEMBL:ENSG00000163931 TKT
ENSEMBL_homo_sapiens_GENE:ENSG00000163931.17 TKT
HGNC:11834 TKT
KEGG Gene (Homo sapiens):7086 TKT
Monarch:7086 TKT
NCBI Gene:7086 TKT
OMIM:606781 TKT
UCSC:P29401 TKT
Reference Transcript
RefSeq:NM_001135055.2 TKT
RefSeq:XM_011534054.1 TKT
RefSeq:NM_001064.3 TKT
RefSeq:NM_001258028.1 TKT
Other Identifiers
11719934_a_at
11754945_x_at
11756952_a_at
16955064
208699_PM_x_at
208699_x_at
208700_3p_s_at
208700_PM_s_at
208700_s_at
228205_PM_at
228205_at
2676670
2676672
2676673
2676674
2676675
2676676
2676677
2676678
2676679
2676681
2676683
2676684
2676687
2676688
2676690
2676691
2676692
2676693
2676695
2676697
2676698
2676699
2676700
2676702
2676704
2676705
2676706
2676714
2676715
38789_at
47520_at
7086
8088106
A_23_P92082
GO:0000287
GO:0003824
GO:0004802
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005777
GO:0005783
GO:0005789
GO:0005829
GO:0006091
GO:0006098
GO:0009052
GO:0016604
GO:0016740
GO:0030976
GO:0031982
GO:0040008
GO:0042803
GO:0043226
GO:0046166
GO:0046872
GO:0055086
GO:0070062
GO:1901135
GO:1901159
HMNXSV003002516
HMNXSV003007084
Hs.89643.0.A1_3p_a_at
Hs.89643.0.A1_3p_x_at
Hs.89643.1.A1_3p_at
ILMN_1736597
L12711_s_at
PH_hs_0005008
TC03001466.hg
g388890_3p_a_at
g388890_3p_x_at
Participates
as a component of
TKT dimer [cytosol] (Homo sapiens)
Inferred To
tkt-1 [cytosol]
(Caenorhabditis elegans)
Dmel\CG5103 [cytosol]
(Drosophila melanogaster)
Homologues of TKT [cytosol]
(Drosophila melanogaster)
TKT [cytosol]
(Bos taurus)
TKT [cytosol]
(Canis familiaris)
TKT [cytosol]
(Mus musculus)
TKT [cytosol]
(Rattus norvegicus)
TKT [cytosol]
(Sus scrofa)
anon-WO0118547.344 [cytosol]
(Drosophila melanogaster)
tkt [cytosol]
(Xenopus tropicalis)
TKTL1 [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_001244957.1
,
NP_001128527.1
,
NP_001055.1
,
XP_011532356.1
OpenTargets
ENSG00000163931
ZINC - Substances
TKT_HUMAN
ZINC target
P29401
PRO
P29401
PDB
3MOS
,
4KXY
,
4KXV
,
6HA3
,
6RJB
,
4KXU
,
4KXX
,
4KXW
,
3OOY
,
6HAD
HPA
ENSG00000163931-TKT
GeneCards
P29401
Ensembl
ENSP00000391481
,
ENST00000423516
,
ENSG00000163931
,
ENSP00000417773
,
ENSP00000405455
,
ENST00000423525
,
ENST00000462138
Pharos - Targets
P29401
ZINC - Predictions - Purchasable
TKT_HUMAN
Orphanet
25437
HMDB Protein
HMDBP00805
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
9
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
10
UniProt:P45983 MAPK8
3
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.527
2
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