Reactome | HSPA4 [nucleoplasm]

HSPA4 [nucleoplasm]

Stable Identifier

R-HSA-5251998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heat shock 70 kDa protein 4, HSP74_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P34932 HSPA4

Gene Names

HSPA4, APG2, HSPH2

Chain

chain:1-840

Reference Genes

BioGPS Gene:3308 HSPA4

COSMIC (genes):HSPA4 HSPA4

CTD Gene:3308 HSPA4

dbSNP Gene:3308 HSPA4

ENSEMBL:ENSG00000170606 HSPA4

HGNC:5237 HSPA4

KEGG:hsa:3308 HSPA4

Monarch:3308 HSPA4

NCBI Gene:3308 HSPA4

OMIM:601113 HSPA4

UCSC:P34932 HSPA4

Reference Transcript

RefSeq:NM_002154.3 HSPA4

Other Identifiers

11717254_at

11717255_x_at

11751837_a_at

11758770_at

1480_at

16989146

208814_PM_at

208814_at

208815_PM_x_at

208815_x_at

211015_PM_s_at

211015_s_at

211016_PM_x_at

211016_x_at

2828857

2828858

2828861

2828862

2828863

2828865

2828866

2828867

2828871

2828874

2828875

2828876

2828877

2828878

2828879

2828881

2828882

2828883

2828884

2828885

2828887

2828888

2828889

2828892

2828894

2828895

2828896

2828897

2828898

3308

38807_at

70778_at

8108015

81506_at

A_24_P277511

A_24_P377269

A_24_P377277

GE53658

GO:0000774

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0006457

GO:0006886

GO:0006986

GO:0007005

GO:0043226

GO:0044183

GO:0045040

GO:0051131

GO:0061024

GO:0065003

GO:0070062

GO:0098772

GO:0140657

GO:0140662

HMNXSV003040851

Hs.90093.2.S2_3p_at

ILMN_1734814

ILMN_1755134

ILMN_2395043

L12723_at

PH_hs_0005035

TC05000649.hg

g12803406_3p_a_at

g292159_3p_a_at

g4579908_3p_a_at

Participates

as a component of

Other forms of this molecule

HSPA4 [cytosol]

Inferred To

SSE2 [nucleoplasm] (Saccharomyces cerevisiae)

hsp-110 [nucleoplasm] (Caenorhabditis elegans)

HSPA4 [nucleoplasm] (Bos taurus)

HSPA4 [nucleoplasm] (Canis familiaris)

HSPA4 [nucleoplasm] (Sus scrofa)

hspa4 [nucleoplasm] (Xenopus tropicalis)

hspH [nucleoplasm] (Dictyostelium discoideum)

pss1 [nucleoplasm] (Schizosaccharomyces pombe)

Hspa4 [nucleoplasm] (Mus musculus)

Hspa4 [nucleoplasm] (Rattus norvegicus)

SSE1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of HSPA4 [nucleoplasm] (Saccharomyces cerevisiae)

hspa4a [nucleoplasm] (Danio rerio)

Cross References

ENSEMBL

ENSP00000302961, ENST00000304858

OpenTargets

ENSG00000170606

HPA

ENSG00000170606-HSPA4

PRO

P34932

Pharos - Targets

P34932

GlyGen

P34932

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.787	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.668	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	2
UniProt:Q8WXB1 METTL21A	1	METTL21A [nucleoplasm] (R-HSA-8876682)	0.527	3
UniProt:Q53H54 TRMT12	1	TRMT12 [cytoplasm] (R-HSA-6782860)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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