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ARHGEF2 [cytosol]
Stable Identifier
R-HSA-195101
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Gef-h1, Arhgef2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF2 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF2 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92974 ARHGEF2
Gene Names
ARHGEF2, KIAA0651, LFP40
Chain
chain:1-986
Reference Genes
BioGPS Gene:9181 ARHGEF2
COSMIC (genes):ARHGEF2 ARHGEF2
CTD Gene:9181 ARHGEF2
dbSNP Gene:9181 ARHGEF2
ENSEMBL:ENSG00000116584 ARHGEF2
ENSEMBL_homo_sapiens_GENE:ENSG00000116584.22 ARHGEF2
HGNC:682 ARHGEF2
KEGG Gene (Homo sapiens):9181 ARHGEF2
Monarch:9181 ARHGEF2
NCBI Gene:9181 ARHGEF2
OMIM:607560 ARHGEF2
UCSC:Q92974 ARHGEF2
Reference Transcript
RefSeq:NM_001162383.1 ARHGEF2
RefSeq:NM_004723.3 ARHGEF2
RefSeq:NM_001162384.1 ARHGEF2
Other Identifiers
11745549_a_at
11749038_a_at
11754291_s_at
1554783_PM_s_at
1554783_s_at
16694361
207629_PM_s_at
207629_s_at
209435_PM_s_at
209435_s_at
2437800
2437802
2437803
2437804
2437805
2437806
2437808
2437809
2437810
2437811
2437812
2437814
2437815
2437816
2437818
2437821
2437822
2437825
2437827
2437828
2437829
2437830
2437831
2437833
2437834
2437835
2437837
2437851
2437852
2437853
2437854
40099_at
40101_g_at
7920877
9181
A_23_P51699
A_33_P3327058
GE53362
GO:0000902
GO:0002376
GO:0005085
GO:0005515
GO:0005737
GO:0005794
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005923
GO:0005925
GO:0006351
GO:0006355
GO:0006886
GO:0007010
GO:0007015
GO:0007026
GO:0007049
GO:0007399
GO:0008017
GO:0008092
GO:0008270
GO:0012501
GO:0016020
GO:0023052
GO:0030154
GO:0031267
GO:0031410
GO:0031982
GO:0032587
GO:0032755
GO:0032760
GO:0032991
GO:0035023
GO:0036211
GO:0042127
GO:0042995
GO:0043226
GO:0045087
GO:0045666
GO:0045944
GO:0046872
GO:0048856
GO:0048870
GO:0050731
GO:0051056
GO:0051092
GO:0051301
GO:0055059
GO:0060546
GO:0070161
GO:0071225
GO:0071356
GO:0071474
GO:0098542
GO:0098772
GO:1902042
GO:1902219
GO:2001224
HMNXSV003010474
Hs2.337774.2.S1_3p_s_at
ILMN_1703477
PH_hs_0016573
TC01003328.hg
U72206_at
g12653008_3p_s_at
g4758671_3p_s_at
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
Inferred To
gxcN [cytosol]
(Dictyostelium discoideum)
ARHGEF2 [cytosol]
(Bos taurus)
ARHGEF2 [cytosol]
(Caenorhabditis elegans)
ARHGEF2 [cytosol]
(Canis familiaris)
ARHGEF2 [cytosol]
(Sus scrofa)
arhgef2 [cytosol]
(Xenopus tropicalis)
Arhgef2 [cytosol]
(Mus musculus)
Arhgef2 [cytosol]
(Rattus norvegicus)
cyst [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001155856.1
,
NP_004714.2
,
NP_001155855.1
OpenTargets
ENSG00000116584
GeneCards
Q92974
HPA
ENSG00000116584-ARHGEF2
Ensembl
ENST00000313667
,
ENST00000361247
,
ENST00000313695
,
ENSG00000116584
,
ENSP00000315325
,
ENSP00000314787
,
ENSP00000354837
PRO
Q92974
Pharos - Targets
Q92974
HMDB Protein
HMDBP08310
PDB
7G98
,
7G8C
,
7G8N
,
7G9G
,
7G97
,
7G93
,
7G9F
,
7G8S
,
7G8J
,
7G8A
,
7G8L
,
7G8U
,
7G96
,
7G9E
,
7G8B
,
7G8T
,
7G8K
,
7G89
,
7G91
,
7G8H
,
7G8Z
,
7G8Q
,
7G9D
,
7G9J
,
7G81
,
7G92
,
7G8I
,
7G86
,
7G8X
,
7G8F
,
7G88
,
7G99
,
7G90
,
7G8P
,
7G8Y
,
7G8V
,
7G84
,
7G9H
,
7G8M
,
7G8D
,
7G85
,
7G8W
,
7G8E
,
7G94
,
7G83
,
5EFX
,
7G95
,
7G82
,
7G9C
,
7G8R
,
7G80
,
7G9B
,
8BNT
,
7G9A
,
7G8O
,
7G9I
,
7G87
,
7G8G
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.763
5
UniProt:P61586 RHOA
6
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
RHOA [cytosol]
(R-HSA-194866)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [plasma membrane]
(R-HSA-194510)
0.666
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.569
4
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.539
5
UniProt:O43524 FOXO3
9
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
FOXO3 [cytosol]
(R-HSA-5687032)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
FOXO3 [nucleoplasm]
(R-HSA-199305)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
4
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