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HYOU1 [endocytic vesicle lumen]
Stable Identifier
R-HSA-3221924
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endocytic vesicle lumen
Synonyms
Hypoxia up-regulated protein 1, HYOU1_HUMAN, GRP170
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class F Receptors (Homo sapiens)
SCARF1:ligand is endocytosed (Homo sapiens)
SCARF1:Ligand [endocytic vesicle membrane] (Homo sapiens)
Ligands of SCARF1 [endocytic vesicle lumen] (Homo sapiens)
HYOU1 [endocytic vesicle lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4L1 HYOU1
Gene Names
HYOU1, GRP170, ORP150, ORP150
Chain
signal peptide:1-32, chain:33-999
Reference Genes
BioGPS Gene:10525 HYOU1
COSMIC (genes):HYOU1 HYOU1
CTD Gene:10525 HYOU1
dbSNP Gene:10525 HYOU1
ENSEMBL:ENSG00000149428 HYOU1
ENSEMBL_homo_sapiens_GENE:ENSG00000149428.21 HYOU1
ENSEMBL_homo_sapiens_GENE:ENSG00000280682.3 HYOU1
HGNC:16931 HYOU1
KEGG Gene (Homo sapiens):10525 HYOU1
Monarch:10525 HYOU1
NCBI Gene:10525 HYOU1
OMIM:601746 HYOU1
UCSC:Q9Y4L1 HYOU1
Reference Transcript
RefSeq:XM_017017096.1 HYOU1
RefSeq:NM_006389.4 HYOU1
RefSeq:NM_001130991.2 HYOU1
RefSeq:XM_017017097.1 HYOU1
Other Identifiers
10525
11716005_a_at
11716006_a_at
11748624_a_at
11748625_x_at
11749688_a_at
11749689_x_at
11750616_a_at
11752033_x_at
11756961_a_at
16745186
200825_PM_s_at
200825_s_at
33863_at
3394124
3394125
3394126
3394127
3394128
3394129
3394130
3394131
3394132
3394133
3394135
3394138
3394140
3394142
3394143
3394144
3394145
3394146
3394147
3394149
3394150
3394151
3394152
3394153
3394154
3394155
3394159
3394160
3394161
3394162
3394164
3394165
3394167
3394168
3394169
3394171
3394172
3394173
3394174
7952145
A_23_P75647
GE59322
GO:0000166
GO:0000774
GO:0002931
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005790
GO:0005925
GO:0006457
GO:0006888
GO:0012501
GO:0016020
GO:0016192
GO:0023052
GO:0031410
GO:0034663
GO:0034976
GO:0043066
GO:0043226
GO:0044183
GO:0051082
GO:0051087
GO:0070062
GO:0071456
GO:0071682
GO:0098772
GO:0140657
GO:0140662
GO:1903298
GO:1903382
HMNXSV003013820
ILMN_1673649
ILMN_2141790
PH_hs_0014249
TC11002361.hg
U65785_at
g13699861_3p_a_at
Participates
as a member of
Ligands of SCARF1 [endocytic vesicle lumen] (Homo sapiens)
Other forms of this molecule
HYOU1 [extracellular region]
HYOU1 [endoplasmic reticulum lumen]
Cross References
RefSeq
XP_016872586.1
,
NP_001124463.1
,
NP_006380.1
,
XP_016872585.1
OpenTargets
ENSG00000149428
HPA
ENSG00000149428-HYOU1
GeneCards
Q9Y4L1
Ensembl
ENSG00000149428
,
ENST00000530473
,
ENSG00000280682
,
ENST00000614711
,
ENSP00000480248
,
ENST00000534233
,
ENSP00000486825
,
ENSP00000431874
,
ENST00000617285
,
ENST00000630669
,
ENSP00000462951
,
ENSP00000480150
PRO
Q9Y4L1
Pharos - Targets
Q9Y4L1
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.669
3
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.643
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
16
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.569
3
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.569
4
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.558
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.527
2
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