Reactome | VPS4B [cytosol]

VPS4B [cytosol]

Stable Identifier

R-HSA-917719

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Vacuolar protein sorting-associated protein 4B, VPS4B_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75351 VPS4B

Gene Names

VPS4B, SKD1, VPS42, MIG1

Chain

chain:1-444

Reference Genes

BioGPS Gene:9525 VPS4B

COSMIC (genes):VPS4B VPS4B

CTD Gene:9525 VPS4B

dbSNP Gene:9525 VPS4B

ENSEMBL:ENSG00000119541 VPS4B

ENSEMBL_homo_sapiens_GENE:ENSG00000119541.10 VPS4B

HGNC:10895 VPS4B

KEGG Gene (Homo sapiens):9525 VPS4B

Monarch:9525 VPS4B

NCBI Gene:9525 VPS4B

OMIM:609983 VPS4B

UCSC:O75351 VPS4B

Reference Transcript

RefSeq:NM_004869.3 VPS4B

Other Identifiers

11739262_at

11739263_x_at

11739264_a_at

16855697

218171_PM_at

218171_at

37804_at

3811498

3811499

3811500

3811501

3811504

3811509

3811510

3811511

3811512

3811513

3811516

3811517

3811518

3811528

3811529

3811530

3811531

54107_at

8023672

9525

A_23_P50156

A_24_P322369

GE61114

GO:0000166

GO:0000278

GO:0000910

GO:0000922

GO:0001525

GO:0001778

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005643

GO:0005737

GO:0005768

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006813

GO:0006914

GO:0006996

GO:0006997

GO:0007010

GO:0007032

GO:0007033

GO:0007034

GO:0007049

GO:0007059

GO:0007080

GO:0007417

GO:0010008

GO:0010824

GO:0010971

GO:0015031

GO:0016020

GO:0016192

GO:0016197

GO:0016236

GO:0016787

GO:0016887

GO:0023052

GO:0030154

GO:0030163

GO:0030301

GO:0030496

GO:0031410

GO:0031468

GO:0031902

GO:0032510

GO:0033993

GO:0036258

GO:0039702

GO:0042060

GO:0042802

GO:0042803

GO:0043162

GO:0043226

GO:0044877

GO:0046761

GO:0048856

GO:0051261

GO:0051301

GO:0060070

GO:0060856

GO:0061024

GO:0061738

GO:0061764

GO:0061952

GO:0070062

GO:0071985

GO:0090148

GO:0090543

GO:0090611

GO:0097352

GO:0140014

GO:0140657

GO:1901673

GO:1903542

GO:1903543

GO:1903724

GO:1904903

GO:1904949

HMNXSV003052869

ILMN_1792587

PH_hs_0007194

TC18000557.hg

g11225484_3p_at

Participates

as a component of

Vps/Vta1 [cytosol] (Homo sapiens)

Inferred To

vps4b [cytosol] (Xenopus tropicalis)

Vps4 [cytosol] (Drosophila melanogaster)

VPS4B [cytosol] (Bos taurus)

VPS4B [cytosol] (Dictyostelium discoideum)

VPS4B [cytosol] (Gallus gallus)

VPS4B [cytosol] (Mus musculus)

VPS4B [cytosol] (Saccharomyces cerevisiae)

VPS4B [cytosol] (Schizosaccharomyces pombe)

VPS4B [cytosol] (Sus scrofa)

Vps4b [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_004860.2

OpenTargets

ENSG00000119541

HPA

ENSG00000119541-VPS4B

GeneCards

O75351

Ensembl

ENSP00000238497, ENSG00000119541, ENST00000238497

PRO

O75351

Pharos - Targets

O75351

Orphanet

25194

HMDB Protein

HMDBP12006

PDB

7L9X, 2JQH, 1WR0, 1XWI, 2CPT, 2JQK, 4U7Y

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.547	2