Reactome | p-LGALS1 [endoplasmic reticulum lumen]

p-LGALS1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8957003

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

LGALS1, Galectin-1, LEG1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P09382 LGALS1

Gene Names

LGALS1

Chain

initiator methionine:1, chain:2-135

Reference Genes

BioGPS Gene:3956 LGALS1

COSMIC (genes):LGALS1 LGALS1

CTD Gene:3956 LGALS1

dbSNP Gene:3956 LGALS1

ENSEMBL:ENSG00000100097 LGALS1

HGNC:6561 LGALS1

KEGG Gene (Homo sapiens):3956 LGALS1

Monarch:3956 LGALS1

NCBI Gene:3956 LGALS1

OMIM:150570 LGALS1

UCSC:P09382 LGALS1

Reference Transcript

RefSeq:NM_002305.3 LGALS1

Other Identifiers

0001740075

11743721_at

16929855

201105_at

33412_at

3944884

3944888

3944892

3944893

3944894

3944897

3956

80667_f_at

8072876

A_23_P166459

GE80497

GO:0002317

GO:0002376

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005788

GO:0005829

GO:0006464

GO:0006915

GO:0006950

GO:0007155

GO:0007165

GO:0008150

GO:0008219

GO:0009986

GO:0010812

GO:0010977

GO:0030154

GO:0030246

GO:0030395

GO:0031012

GO:0031295

GO:0034120

GO:0035900

GO:0042493

GO:0042592

GO:0042802

GO:0042981

GO:0043123

GO:0043226

GO:0043236

GO:0043687

GO:0044267

GO:0044403

GO:0045445

GO:0046598

GO:0048678

GO:0048856

GO:0062023

GO:0070062

GO:0071333

GO:0071407

HMNXSV003050354

ILMN_1723978

J04456_at

PH_hs_0024712

TC22000285.hg

g6006015_3p_at

g6006015_3p_x_at

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

LGALS1 [endoplasmic reticulum lumen]

Inferred To

phospho-lec-2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-lec-6 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-lgals1.1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

phospho-LGALS1 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-lec-11 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-lec-5 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-lec-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-Dmel\CG5335 [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-pqn-84 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-lec-8 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-CG-1B [endoplasmic reticulum lumen] (Gallus gallus)

phospho-p-LGALS1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-p-LGALS1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-p-LGALS1 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-lec-4 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-Lgals1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-Lgals1 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-Dmel\CG13950 [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-lec-7 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-lec-9 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-lgals2b [endoplasmic reticulum lumen] (Danio rerio)

Homologues of p-LGALS1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Homologues of p-LGALS1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Homologues of p-LGALS1 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-lec-3 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-lec-10 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_002296.1

OpenTargets

ENSG00000100097

ZINC - Substances

LEG1_HUMAN

ZINC target

P09382

PRO

P09382

GlyGen

P09382

PDB

4Y1U, 1W6M, 4Y1V, 6B94, 4Q1P, 3OYW, 4Q1R, 4Y1X, 4Y1Y, 2KM2, 4Y20, 4Q26, 4Q27, 4Y1Z, 1W6Q, 3W59, 5MWT, 4Y22, 1W6P, 5MWX, 4Y24, 2ZKN, 1GZW, 3OY8, 6F83, 1W6O, 3W58, 3T2T, 1W6N, 4XBL, 4Q2F

ZINC - Investigational

LEG1_HUMAN

HPA

ENSG00000100097-LGALS1

GeneCards

P09382

Ensembl

ENST00000215909, ENSP00000215909, ENSG00000100097

Pharos - Targets

P09382

ZINC - Predictions - Purchasable

LEG1_HUMAN

HMDB Protein

HMDBP02427

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16284 PECAM1	4	PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [platelet alpha granule membrane] (R-HSA-61489) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007)	0.675	4
UniProt:Q13740 ALCAM	1	ALCAM [plasma membrane] (R-HSA-197750)	0.611	3
UniProt:P35968 KDR	4	VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.602	3
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.558	2
UniProt:P02649 APOE	10	APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE-4 [extracellular region] (R-HSA-9711070) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [plasma membrane] (R-HSA-174615) APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) APOE [endocytic vesicle lumen] (R-HSA-3221641)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [endoplasmic reticulum lumen] (R-HSA-195905)	0.556	3
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4

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