NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]

Stable Identifier
R-HSA-9730703
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Nucleophosmin, B23, NPM_HUMAN
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
7780128 Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction

Downing, JR, Shurtleff, SA, Zielenska, M, Curcio-Brint, AM, Behm, FG, Head, DR, Sandlund, JT, Weisenburger, DD, Kossakowska, AE, Thorner, P

Blood 1995
External Reference Information
External Reference
UniProt:P06748 NPM1
Gene Names
NPM1, NPM
Chain
chain:1-294
Reference Genes
BioGPS Gene:4869 NPM1
COSMIC (genes):NPM1 NPM1
CTD Gene:4869 NPM1
dbSNP Gene:4869 NPM1
ENSEMBL:ENSG00000181163 NPM1
HGNC:7910 NPM1
KEGG:hsa:4869 NPM1
Monarch:4869 NPM1
NCBI Gene:4869 NPM1
OMIM:164040 NPM1
UCSC:P06748 NPM1
Reference Transcript
Participates
as a component of
Other forms of this molecule
NPM1 [cytosol]
p-S4-NPM1 [cytosol]
NPM1 [nucleoplasm]
NPM1 [granular component]
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
polySUMO2,3-K263-NPM1 [nucleoplasm]
monoSUMO1-K263-NPM1 [nucleoplasm]
Modified Residues
Name
Insertion of residues 1068 to 1620 at 118 from UniProt:Q9UM73 ALK
Coordinate
118
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1359
Coordinate
1359
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
lymphoma DOID:0060058 lymphoid cancer
non-Hodgkin lymphoma DOID:0060060
Cross References
RefSeq
OpenTargets
ENSEMBL
Mondo
GeneCards
HPA
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (221)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q96BK5 PINX1      0.81 13
 UniProt:O75607 NPM3      0.788 7
 UniProt:Q9H4L4 SENP3  1 0.78 7
 UniProt:Q86SE8 NPM2  1 0.743 8
 UniProt:Q96GD4 AURKB  3 0.712 6
 UniProt:Q9BQG0 MYBBP1A  1 0.712 4
 UniProt:Q14137 BOP1  1 0.706 4
 UniProt:P46777 RPL5  1 0.706 4
 UniProt:O96028 NSD2  2 0.706 4
 UniProt:Q15050 RRS1      0.706 5
 UniProt:Q14684 RRP1B      0.706 5
 UniProt:Q9ULW3 ABT1      0.706 4
 UniProt:Q13823 NOG2      0.706 4
 UniProt:Q00987 MDM2  11 0.697 5
 UniProt:P04637 TP53  20 0.676 6
 UniProt:Q71RC2 LARP4      0.669 3
 UniProt:Q8IZL8 PELP1  1 0.664 4
 UniProt:P62753 RPS6  4 0.65 3
 UniProt:Q96CT7 CC124      0.649 8
 UniProt:Q1ED39 KNOP1      0.643 3
 UniProt:Q14690 PDCD11  1 0.643 3
 UniProt:Q9BZE4 GTPB4      0.643 4
 UniProt:P61313 RPL15  1 0.643 3
 UniProt:P46781 RPS9  2 0.643 3
 UniProt:Q6NW34 NEPRO      0.643 4
 UniProt:O60264 SMARCA5  1 0.643 3
 UniProt:Q15397 PUM3      0.643 4
 UniProt:P60228 EIF3E  1 0.64 3
 UniProt:B1Q2W9 B1Q2W9      0.639 8
 UniProt:P24938 CORE5      0.623 4
 UniProt:Q6UPD4 Q6UPD4      0.619 4
 UniProt:Q68D10 SPT2      0.615 3
 UniProt:Q14692 BMS1  1 0.615 3
 UniProt:P05386 RPLP1  1 0.615 3
 UniProt:Q9H501 ESF1      0.615 3
 UniProt:Q9NRX1 PNO1  2 0.615 3
 UniProt:Q9GZL7 WDR12  1 0.615 3
 UniProt:P42696 RBM34      0.615 4
 UniProt:Q9NZM5 NOP53      0.615 4
 UniProt:O15226 NKRF      0.615 3
 UniProt:P11388 TOP2A  3 0.615 3
 UniProt:P13569 CFTR  17 0.615 15
 UniProt:Q9UIG0 BAZ1B  1 0.615 3
 UniProt:P19338 NCL  4 0.615 3
 UniProt:Q5QJE6 TDIF2      0.615 3
 UniProt:Q9H6F5 CCD86      0.615 3
 UniProt:Q9NQZ2 UTP3  1 0.615 3
 UniProt:Q9Y3C1 NOP16      0.615 4
 UniProt:O00566 MPHOSPH10  1 0.615 3
 UniProt:O15381 NVL      0.615 3
 UniProt:Q12788 TBL3  1 0.615 3
 UniProt:Q9BVJ6 UTP14A  1 0.615 3
 UniProt:Q9Y3B9 RRP15      0.615 3
 UniProt:Q6PK04 CC137      0.615 3
 UniProt:Q01780 EXOSC10  2 0.615 3
 UniProt:Q96GQ7 DDX27      0.615 4
 UniProt:Q9BYG3 MK67I      0.615 3
 UniProt:Q9BQ39 DDX50      0.615 3
 UniProt:Q9NW13 RBM28  1 0.615 3
 UniProt:O43159 RRP8  1 0.615 4
 UniProt:P19525 EIF2AK2  5 0.602 4
 UniProt:Q9BZQ8 NIBA1      0.602 7
 UniProt:Q9BXL5 HEMGN      0.599 7
 UniProt:P49450 CENPA  2 0.597 4
 UniProt:P68951 NP      0.591 5
 UniProt:P05549 TFAP2A  1 0.591 6
 UniProt:O00505 KPNA3  2 0.59 2
 UniProt:P0DOE7 M  5 0.576 3
 UniProt:O14746 TERT  1 0.576 5
 UniProt:O00629 KPNA4  2 0.571 2
 UniProt:Q9NX58 LYAR      0.564 2
 UniProt:P63104 YWHAZ  2 0.564 2
 UniProt:Q96MT8 CEP63  1 0.564 2
 UniProt:Q8N726 CDKN2A  12 0.564 2
 UniProt:P49207 RPL34  1 0.564 2
 UniProt:Q92876 KLK6      0.556 3
 UniProt:P10176 COX8A  1 0.556 3
 UniProt:Q86SE8-2 NPM2      0.556 5
 UniProt:P03427 PB2      0.547 3
 UniProt:Q8N3Z6 ZCCHC7  1 0.536 2
 UniProt:Q03164 KMT2A  6 0.536 2
 UniProt:P03372 ESR1  10 0.532 3
 UniProt:O76021 RL1D1      0.527 2
 UniProt:Q92522 H1X      0.527 2
 UniProt:Q6PGP7 SKIC3  1 0.527 2
 UniProt:P62263 RPS14  2 0.527 2
 UniProt:Q07020 RPL18  1 0.527 2
 UniProt:Q9HCM4 EPB41L5  1 0.527 2
 UniProt:Q9H7E9 CH033      0.527 2
 UniProt:Q99848 EBNA1BP2  1 0.527 3
 UniProt:P39019 RPS19  2 0.527 2
 UniProt:Q6PKG0 LARP1  1 0.527 2
 UniProt:P63220 RPS21  2 0.527 2
 UniProt:P10636-8 MAPT  3 0.527 6
 UniProt:P62241 RPS8  2 0.527 2
 UniProt:P60866 RPS20  3 0.527 2
 UniProt:Q5JTH9 RRP12      0.527 2
 UniProt:Q9H9Y2 RPF1      0.527 3
 UniProt:Q6P158 DHX57      0.527 2
 UniProt:Q49A26 GLYR1      0.527 3
 UniProt:P49711 CTCF  1 0.527 2
 UniProt:Q71UM5 RPS27L  2 0.527 2
 UniProt:Q14694 USP10  3 0.527 2
 UniProt:P62861 FAU  2 0.527 2
 UniProt:Q969S3 ZN622      0.527 2
 UniProt:P36578 RPL4  1 0.527 3
 UniProt:Q9GZR2 REXO4      0.527 3
 UniProt:P46013 KI67      0.527 2
 UniProt:Q9P275 UBP36      0.527 3
 UniProt:O75818 RPP40  1 0.527 3
 UniProt:P19320 VCAM1  1 0.527 4
 UniProt:O75934 BCAS2  1 0.527 2
 UniProt:P15880 RPS2  3 0.527 2
 UniProt:P35251 RFC1  1 0.527 2
 UniProt:Q9P287 BCCIP      0.527 2
 UniProt:P62857 RPS28  2 0.527 2
 UniProt:P61513 RPL37A  1 0.527 2
 UniProt:Q99613 EIF3C  1 0.527 2
 UniProt:P62280 RPS11  2 0.527 2
 UniProt:Q9NXF1 TEX10  1 0.527 3
 UniProt:Q9NV31 IMP3  1 0.527 2
 UniProt:P62424 RPL7A  1 0.527 2
 UniProt:P22087 FBL  1 0.527 2
 UniProt:O00567 NOP56  2 0.527 2
 UniProt:Q96PV0 SYNGAP1  1 0.527 2
 UniProt:Q7Z478 DHX29      0.527 2
 UniProt:P35268 RPL22  1 0.527 2
 UniProt:Q06787 FMR1      0.527 3
 UniProt:O75683 SURF6      0.527 3
 UniProt:P62750 RPL23A  1 0.527 3
 UniProt:O76094 SRP72  1 0.527 2
 UniProt:Q8TDN6 BRX1      0.527 3
 UniProt:Q14152 EIF3A  1 0.527 2
 UniProt:P50914 RPL14  1 0.527 2
 UniProt:O95707 POP4  1 0.527 3
 UniProt:Q15477 SKIC2  1 0.527 2
 UniProt:Q9UNX4 WDR3  1 0.527 2
 UniProt:P62906 RPL10A  1 0.527 2
 UniProt:Q96HI0 SENP5  1 0.527 3
 UniProt:Q8TDD1 DDX54      0.527 3
 UniProt:Q8IUF8 RIOX2  1 0.527 2
 UniProt:P46783 RPS10  3 0.527 2
 UniProt:P46782 RPS5  2 0.527 2
 UniProt:Q9H7B2 RPF2      0.527 2
 UniProt:Q13283 G3BP1  1 0.527 2
 UniProt:Q99575 POP1  1 0.527 2
 UniProt:P78346 RPP30  1 0.527 2
 UniProt:Q7KZF4 SND1  2 0.527 2
 UniProt:Q9Y4W2 LAS1L  1 0.527 2
 UniProt:P40429 RPL13A  2 0.527 2
 UniProt:O60287 NPA1P      0.527 3
 UniProt:Q6DKI1 RL7L      0.527 3
 UniProt:Q15572 TAF1C  1 0.527 2
 UniProt:Q8IY81 FTSJ3  1 0.527 3
 UniProt:Q13547 HDAC1  2 0.524 2
 UniProt:Q98147 Q98147      0.524 2
 UniProt:Q14684-1 RRP1B      0.512 4
 UniProt:Q10570 CPSF1  1 0.499 2
 UniProt:Q9UQ80 PA2G4  2 0.491 3
 UniProt:O14965 AURKA  6 0.489 3
 UniProt:Q8N8A6 DDX51      0.483 2
 UniProt:Q8NHQ9 DDX55      0.483 3
 UniProt:Q9NY61 AATF  1 0.483 2
 UniProt:Q9BXY0 MAK16      0.483 3
 UniProt:Q8N9T8 KRI1      0.483 2
 UniProt:P48634 PRC2A      0.483 2
 UniProt:Q96SB4 SRPK1  2 0.483 2
 UniProt:Q08J23 NSUN2  1 0.483 2
 UniProt:P36873 PPP1CC  1 0.483 2
 UniProt:Q9BRJ6 CHOLN      0.483 2
 UniProt:P19784 CSNK2A2  2 0.483 2
 UniProt:O95793 STAU1      0.483 2
 UniProt:Q6MZP7 LIN54  1 0.483 2
 UniProt:Q8NEJ9 NGDN      0.483 2
 UniProt:Q9BTD8 RBM42  1 0.483 2
 UniProt:Q9NVU7 SDA1      0.483 2
 UniProt:P35250 RFC2  1 0.483 2
 UniProt:Q96T88 UHRF1  2 0.483 2
 UniProt:Q04637 EIF4G1  2 0.483 2
 UniProt:Q9H6Y2 WDR55      0.483 2
 UniProt:O15213 WDR46  1 0.483 2
 UniProt:Q9BSC4 NOL10      0.483 2
 UniProt:Q9ULJ3 ZBT21      0.483 2
 UniProt:Q96B26 EXOSC8  3 0.483 2
 UniProt:Q8IY37 DHX37  1 0.483 2
 UniProt:Q14781 CBX2  1 0.483 2
 UniProt:Q2TB10 ZN800      0.483 3
 UniProt:Q96L73 NSD1  1 0.483 2
 UniProt:Q13206 DDX10      0.483 2
 UniProt:O95639 CPSF4  1 0.483 2
 UniProt:Q02880 TOP2B  2 0.483 2
 UniProt:O95625 ZBT11      0.483 2
 UniProt:Q9BRD0 BUD13  1 0.483 3
 UniProt:Q86U86 PBRM1  1 0.483 2
 UniProt:Q13895 BYSL  2 0.483 2
 UniProt:Q8WYP5 AHCTF1  1 0.483 2
 UniProt:Q03188 CENPC  2 0.483 2
 UniProt:Q9HC52 CBX8  1 0.483 2
 UniProt:Q9Y2R4 DDX52  1 0.483 2
 UniProt:Q9Y4C8 RBM19      0.483 2
 UniProt:Q86VM9 ZC3H18  1 0.483 3
 UniProt:Q14966 ZNF638  1 0.483 2
 UniProt:Q12789 GTF3C1  1 0.483 2
 UniProt:O00541 PES1  1 0.483 2
 UniProt:Q9Y676 MRPS18B  1 0.483 2
 UniProt:O75533 SF3B1  1 0.483 3
 UniProt:P78362 SRPK2  1 0.483 2
 UniProt:P00533 EGFR  20 0.483 5
 UniProt:P20700 LMNB1  8 0.483 2
 UniProt:Q9NUL3 STAU2      0.483 2
 UniProt:Q03701 CEBPZ      0.483 2
 UniProt:Q9NQT5 EXOSC3  3 0.483 2
 UniProt:Q8NDF8 TENT4B  1 0.483 3
 UniProt:Q99459 CDC5L  1 0.483 2
 UniProt:Q8NFW8 CMAS  1 0.483 2
 UniProt:P78344 EIF4G2  1 0.483 2
 UniProt:P78345 RPP38  1 0.483 3
 UniProt:Q9HCK8 CHD8  1 0.483 2
 UniProt:Q9H9L3 ISG20L2  1 0.483 2
 UniProt:Q8IUH3 RBM45      0.462 2
 UniProt:P11387 TOP1  2 0.462 3
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