Reactome | NPM1(1-117)-ALK(1058-1620) fusion [cytosol]

NPM1(1-117)-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9699834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Nucleophosmin, B23, NPM_HUMAN

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
8633037	Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5) Fujimoto, J, Shiota, M, Iwahara, T, Seki, N, Satoh, H, Mori, S, Yamamoto, T	Proc. Natl. Acad. Sci. U.S.A.	1996
7824924	Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma Morris, SW, Kirstein, MN, Valentine, MB, Dittmer, K, Shapiro, DN, Look, AT, Saltman, DL	Science	1995

External Reference Information

External Reference

UniProt:P06748 NPM1

Gene Names

NPM1, NPM

Chain

chain:1-294

Reference Genes

BioGPS Gene:4869 NPM1

COSMIC (genes):NPM1 NPM1

CTD Gene:4869 NPM1

dbSNP Gene:4869 NPM1

ENSEMBL:ENSG00000181163 NPM1

HGNC:7910 NPM1

KEGG:hsa:4869 NPM1

Monarch:4869 NPM1

NCBI Gene:4869 NPM1

OMIM:164040 NPM1

UCSC:P06748 NPM1

Reference Transcript

Participates

as a member of

ALK fusion proteins [cytosol] (Homo sapiens)

as a component of

NPM1(1-117)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

NPM1 [cytosol]

p-S4-NPM1 [cytosol]

NPM1 [nucleoplasm]

NPM1 [granular component]

NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]

NPM1(1-117)-ALK(1068-1620) fusion [cytosol]

NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]

NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]

polySUMO2,3-K263-NPM1 [nucleoplasm]

monoSUMO1-K263-NPM1 [nucleoplasm]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 118 from UniProt:Q9UM73 ALK

Coordinate

118

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
lymphoma	DOID:0060058	lymphoid cancer
non-Hodgkin lymphoma	DOID:0060060

Cross References

RefSeq

NP_954654.1, NP_002511.1, NP_001032827.1, NP_001341935.1

COSMIC

COSF198

OpenTargets

ENSG00000181163

ENSEMBL

ENSP00000377408, ENST00000351986, ENST00000296930, ENSP00000341168, ENST00000393820, ENST00000517671, ENSP00000503235, ENSP00000428755, ENSP00000296930, ENSG00000181163, ENST00000678280

Mondo

0018908

GeneCards

NPM1

HPA

ENSG00000181163-NPM1

PRO

P06748

Pharos - Targets

P06748

GlyGen

P06748

Orphanet

NPM1

PDB

2P1B, 2VXD, 2LLH, 8AS5, 8AH2, 7OBH, 7OBG, 5EHD

Interactors (221)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BK5 PINX1			0.81	13
UniProt:O75607 NPM3			0.788	7
UniProt:Q9H4L4 SENP3	1	SENP3 [nucleoplasm] (R-HSA-2984296)	0.78	7
UniProt:Q86SE8 NPM2	1	NPM2 [nucleoplasm] (R-HSA-9821980)	0.743	8
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.712	6
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.712	4
UniProt:Q14137 BOP1	1	BOP1 [nucleoplasm] (R-HSA-6791206)	0.706	4
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.706	4
UniProt:O96028 NSD2	2	WHSC1 [nucleoplasm] (R-HSA-1183215) p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984)	0.706	4
UniProt:Q15050 RRS1			0.706	5
UniProt:Q14684 RRP1B			0.706	5
UniProt:Q9ULW3 ABT1			0.706	4
UniProt:Q13823 NOG2			0.706	4
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.697	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.676	6
UniProt:Q71RC2 LARP4			0.669	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.664	4
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.65	3
UniProt:Q96CT7 CC124			0.649	8
UniProt:Q1ED39 KNOP1			0.643	3
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.643	3
UniProt:Q9BZE4 GTPB4			0.643	4
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.643	3
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.643	3
UniProt:Q6NW34 NEPRO			0.643	4
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.643	3
UniProt:Q15397 PUM3			0.643	4
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.64	3
UniProt:B1Q2W9 B1Q2W9			0.639	8
UniProt:P24938 CORE5			0.623	4
UniProt:Q6UPD4 Q6UPD4			0.619	4
UniProt:Q68D10 SPT2			0.615	3
UniProt:Q14692 BMS1	1	BMS1 [nucleoplasm] (R-HSA-6790720)	0.615	3
UniProt:P05386 RPLP1	1	RPLP1 [cytosol] (R-HSA-72398)	0.615	3
UniProt:Q9H501 ESF1			0.615	3
UniProt:Q9NRX1 PNO1	2	PNO1 [nucleoplasm] (R-HSA-6791540) PNO1 [cytosol] (R-HSA-6791509)	0.615	3
UniProt:Q9GZL7 WDR12	1	WDR12 [nucleoplasm] (R-HSA-6791215)	0.615	3
UniProt:P42696 RBM34			0.615	4
UniProt:Q9NZM5 NOP53			0.615	4
UniProt:O15226 NKRF			0.615	3
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.615	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	15
UniProt:Q9UIG0 BAZ1B	1	BAZ1B [nucleoplasm] (R-HSA-417153)	0.615	3
UniProt:P19338 NCL	4	NCL [cytosol] (R-HSA-450514) NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.615	3
UniProt:Q5QJE6 TDIF2			0.615	3
UniProt:Q9H6F5 CCD86			0.615	3
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.615	3
UniProt:Q9Y3C1 NOP16			0.615	4
UniProt:O00566 MPHOSPH10	1	MPHOSPH10 [nucleoplasm] (R-HSA-6790661)	0.615	3
UniProt:O15381 NVL			0.615	3
UniProt:Q12788 TBL3	1	TBL3 [nucleoplasm] (R-HSA-6790620)	0.615	3
UniProt:Q9BVJ6 UTP14A	1	UTP14A [nucleoplasm] (R-HSA-6790695)	0.615	3
UniProt:Q9Y3B9 RRP15			0.615	3
UniProt:Q6PK04 CC137			0.615	3
UniProt:Q01780 EXOSC10	2	EXOSC10 [nucleoplasm] (R-HSA-6791547) EXOSC10 [nucleolus] (R-HSA-9935809)	0.615	3
UniProt:Q96GQ7 DDX27			0.615	4
UniProt:Q9BYG3 MK67I			0.615	3
UniProt:Q9BQ39 DDX50			0.615	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.615	3
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.615	4
UniProt:P19525 EIF2AK2	5	EIF2AK2 [cytosol] (R-HSA-168699) p-EIF2AK2 [cytosol] (R-HSA-9833834) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) p-EIF2AK2 [nucleoplasm] (R-HSA-9836332)	0.602	4
UniProt:Q9BZQ8 NIBA1			0.602	7
UniProt:Q9BXL5 HEMGN			0.599	7
UniProt:P49450 CENPA	2	CENPA [cytosol] (R-HSA-375317) CENPA [nucleoplasm] (R-HSA-606322)	0.597	4
UniProt:P68951 NP			0.591	5
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.591	6
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.59	2
UniProt:P0DOE7 M	5	p-S95,T205-M [cytosol] (R-RSY-9831678) p-S95,T205-M [nucleoplasm] (R-RSY-9831706) M [nucleoplasm] (R-RSY-9831711) Nascent M [cytosol] (R-RSY-9828672) p-S95,T205-M [viral tegument] (R-RSY-9836531)	0.576	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.576	5
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.571	2
UniProt:Q9NX58 LYAR			0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.564	2
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.564	2
UniProt:P49207 RPL34	1	RPL34 [cytosol] (R-HSA-72458)	0.564	2
UniProt:Q92876 KLK6			0.556	3
UniProt:P10176 COX8A	1	COX8A [mitochondrial inner membrane] (R-HSA-164313)	0.556	3
UniProt:Q86SE8-2 NPM2			0.556	5
UniProt:P03427 PB2			0.547	3
UniProt:Q8N3Z6 ZCCHC7	1	ZCCHC7 [nucleolus] (R-HSA-9930045)	0.536	2
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.536	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.532	3
UniProt:O76021 RL1D1			0.527	2
UniProt:Q92522 H1X			0.527	2
UniProt:Q6PGP7 SKIC3	1	TTC37 [cytosol] (R-HSA-8931541)	0.527	2
UniProt:P62263 RPS14	2	RPS14 [cytosol] (R-HSA-72333) RPS14 [nucleoplasm] (R-HSA-6790669)	0.527	2
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:Q9HCM4 EPB41L5	1	EPB41L5 [cytosol] (R-HSA-6797564)	0.527	2
UniProt:Q9H7E9 CH033			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	3
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.527	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:P63220 RPS21	2	RPS21 [cytosol] (R-HSA-72351) RPS21 [nucleoplasm] (R-HSA-6798732)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	6
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:P60866 RPS20	3	RPS20 [cytosol] (R-HSA-72349) K63polyUb-K8-RPS20 [cytosol] (R-HSA-9948312) RPS20 [nucleoplasm] (R-HSA-6798727)	0.527	2
UniProt:Q5JTH9 RRP12			0.527	2
UniProt:Q9H9Y2 RPF1			0.527	3
UniProt:Q6P158 DHX57			0.527	2
UniProt:Q49A26 GLYR1			0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:Q71UM5 RPS27L	2	RPS27L [nucleoplasm] (R-HSA-6791197) RPS27L [cytosol] (R-HSA-8868849)	0.527	2
UniProt:Q14694 USP10	3	USP10 [nucleoplasm] (R-HSA-3222218) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [cytosol] (R-HSA-6782974)	0.527	2
UniProt:P62861 FAU	2	FAU [cytosol] (R-HSA-72371) FAU [nucleoplasm] (R-HSA-6798717)	0.527	2
UniProt:Q969S3 ZN622			0.527	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	3
UniProt:Q9GZR2 REXO4			0.527	3
UniProt:P46013 KI67			0.527	2
UniProt:Q9P275 UBP36			0.527	3
UniProt:O75818 RPP40	1	RPP40 [nucleoplasm] (R-HSA-5696801)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O75934 BCAS2	1	BCAS2 [nucleoplasm] (R-HSA-5420902)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2
UniProt:P35251 RFC1	1	RFC1 [nucleoplasm] (R-HSA-68435)	0.527	2
UniProt:Q9P287 BCCIP			0.527	2
UniProt:P62857 RPS28	2	RPS28 [cytosol] (R-HSA-72365) RPS28 [nucleoplasm] (R-HSA-6791202)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:Q99613 EIF3C	1	EIF3C [cytosol] (R-HSA-72550)	0.527	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.527	2
UniProt:Q9NXF1 TEX10	1	TEX10 [nucleoplasm] (R-HSA-3826589)	0.527	3
UniProt:Q9NV31 IMP3	1	IMP3 [nucleoplasm] (R-HSA-6790664)	0.527	2
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.527	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.527	2
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:Q7Z478 DHX29			0.527	2
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.527	2
UniProt:Q06787 FMR1			0.527	3
UniProt:O75683 SURF6			0.527	3
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.527	3
UniProt:O76094 SRP72	1	SRP72 [cytosol] (R-HSA-265069)	0.527	2
UniProt:Q8TDN6 BRX1			0.527	3
UniProt:Q14152 EIF3A	1	EIF3A [cytosol] (R-HSA-72546)	0.527	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	2
UniProt:O95707 POP4	1	POP4 [nucleoplasm] (R-HSA-5696789)	0.527	3
UniProt:Q15477 SKIC2	1	SKIV2L [cytosol] (R-HSA-391294)	0.527	2
UniProt:Q9UNX4 WDR3	1	WDR3 [nucleoplasm] (R-HSA-6790724)	0.527	2
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.527	2
UniProt:Q96HI0 SENP5	1	SENP5 [nucleoplasm] (R-HSA-2984297)	0.527	3
UniProt:Q8TDD1 DDX54			0.527	3
UniProt:Q8IUF8 RIOX2	1	RIOX2 [nucleoplasm] (R-HSA-8942439)	0.527	2
UniProt:P46783 RPS10	3	RPS10 [cytosol] (R-HSA-72325) K63polyUb-K138,K139-RPS10 [cytosol] (R-HSA-9948298) RPS10 [nucleoplasm] (R-HSA-6798733)	0.527	2
UniProt:P46782 RPS5	2	RPS5 [cytosol] (R-HSA-72379) RPS5 [nucleoplasm] (R-HSA-6791188)	0.527	2
UniProt:Q9H7B2 RPF2			0.527	2
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:Q99575 POP1	1	POP1 [nucleoplasm] (R-HSA-5696802)	0.527	2
UniProt:P78346 RPP30	1	RPP30 [nucleoplasm] (R-HSA-5696779)	0.527	2
UniProt:Q7KZF4 SND1	2	SND1(1-593)-BRAF(381-766) fusion [cytosol] (R-HSA-6802469) SND1(1-593)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802552)	0.527	2
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.527	2
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.527	2
UniProt:O60287 NPA1P			0.527	3
UniProt:Q6DKI1 RL7L			0.527	3
UniProt:Q15572 TAF1C	1	TAF1C [nucleoplasm] (R-HSA-73687)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.524	2
UniProt:Q98147 Q98147			0.524	2
UniProt:Q14684-1 RRP1B			0.512	4
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.499	2
UniProt:Q9UQ80 PA2G4	2	PA2G4 [azurophil granule lumen] (R-HSA-6799205) PA2G4 [extracellular region] (R-HSA-6806200)	0.491	3
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.489	3
UniProt:Q8N8A6 DDX51			0.483	2
UniProt:Q8NHQ9 DDX55			0.483	3
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.483	2
UniProt:Q9BXY0 MAK16			0.483	3
UniProt:Q8N9T8 KRI1			0.483	2
UniProt:P48634 PRC2A			0.483	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.483	2
UniProt:Q08J23 NSUN2	1	NSUN2 [nucleoplasm] (R-HSA-6782382)	0.483	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.483	2
UniProt:Q9BRJ6 CHOLN			0.483	2
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.483	2
UniProt:O95793 STAU1			0.483	2
UniProt:Q6MZP7 LIN54	1	LIN54 [nucleoplasm] (R-HSA-389103)	0.483	2
UniProt:Q8NEJ9 NGDN			0.483	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.483	2
UniProt:Q9NVU7 SDA1			0.483	2
UniProt:P35250 RFC2	1	RFC2 [nucleoplasm] (R-HSA-68433)	0.483	2
UniProt:Q96T88 UHRF1	2	UHRF1 [nucleoplasm] (R-HSA-212103) UHRF1 [cytosol] (R-HSA-9818452)	0.483	2
UniProt:Q04637 EIF4G1	2	EIF4G1 [cytosol] (R-HSA-72584) p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762)	0.483	2
UniProt:Q9H6Y2 WDR55			0.483	2
UniProt:O15213 WDR46	1	WDR46 [nucleoplasm] (R-HSA-6790677)	0.483	2
UniProt:Q9BSC4 NOL10			0.483	2
UniProt:Q9ULJ3 ZBT21			0.483	2
UniProt:Q96B26 EXOSC8	3	EXOSC8 [cytosol] (R-HSA-429912) EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [nucleolus] (R-HSA-9935805)	0.483	2
UniProt:Q8IY37 DHX37	1	DHX37 [nucleoplasm] (R-HSA-6790668)	0.483	2
UniProt:Q14781 CBX2	1	CBX2 [nucleoplasm] (R-HSA-389110)	0.483	2
UniProt:Q2TB10 ZN800			0.483	3
UniProt:Q96L73 NSD1	1	NSD1 [nucleoplasm] (R-HSA-1183232)	0.483	2
UniProt:Q13206 DDX10			0.483	2
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.483	2
UniProt:Q02880 TOP2B	2	TOP2B [nucleoplasm] (R-HSA-4641359) monoSUMO1-K-TOP2B [nucleoplasm] (R-HSA-4641297)	0.483	2
UniProt:O95625 ZBT11			0.483	2
UniProt:Q9BRD0 BUD13	1	BUD13 [nucleoplasm] (R-HSA-9769522)	0.483	3
UniProt:Q86U86 PBRM1	1	PBRM1 [nucleoplasm] (R-HSA-389254)	0.483	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.483	2
UniProt:Q8WYP5 AHCTF1	1	AHCTF1 [cytosol] (R-HSA-376244)	0.483	2
UniProt:Q03188 CENPC	2	CENPC [nucleoplasm] (R-HSA-5633512) CENPC1 [cytosol] (R-HSA-375292)	0.483	2
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.483	2
UniProt:Q9Y2R4 DDX52	1	DDX52 [nucleoplasm] (R-HSA-6790703)	0.483	2
UniProt:Q9Y4C8 RBM19			0.483	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.483	3
UniProt:Q14966 ZNF638	1	ZNF638 [nucleoplasm] (R-HSA-8939429)	0.483	2
UniProt:Q12789 GTF3C1	1	GTF3C1 [nucleoplasm] (R-HSA-83697)	0.483	2
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.483	2
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.483	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.483	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.483	2
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.483	5
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.483	2
UniProt:Q9NUL3 STAU2			0.483	2
UniProt:Q03701 CEBPZ			0.483	2
UniProt:Q9NQT5 EXOSC3	3	EXOSC3 [cytosol] (R-HSA-430017) EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [nucleolus] (R-HSA-9935842)	0.483	2
UniProt:Q8NDF8 TENT4B	1	TENT4B [nucleolus] (R-HSA-9935834)	0.483	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.483	2
UniProt:Q8NFW8 CMAS	1	CMAS [nucleoplasm] (R-HSA-4085417)	0.483	2
UniProt:P78344 EIF4G2	1	EIF4G2 [cytosol] (R-HSA-1678826)	0.483	2
UniProt:P78345 RPP38	1	RPP38 [nucleoplasm] (R-HSA-5696791)	0.483	3
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:Q9H9L3 ISG20L2	1	ISG20L2 [nucleoplasm] (R-HSA-6799476)	0.483	2
UniProt:Q8IUH3 RBM45			0.462	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	3

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