Reactome | PolyUb-VDAC2 [mitochondrial outer membrane]

PolyUb-VDAC2 [mitochondrial outer membrane]

Stable Identifier

R-HSA-6783185

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

VDAC2, Voltage-dependent anion-selective channel protein 2, VDAC2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P45880 VDAC2

Gene Names

VDAC2

Chain

initiator methionine:1, chain:2-294

Reference Genes

BioGPS Gene:7417 VDAC2

COSMIC (genes):VDAC2 VDAC2

CTD Gene:7417 VDAC2

dbSNP Gene:7417 VDAC2

ENSEMBL:ENSG00000165637 VDAC2

ENSEMBL:ENSG00000165637.14 VDAC2

HGNC:12672 VDAC2

KEGG Gene (Homo sapiens):7417 VDAC2

Monarch:7417 VDAC2

NCBI Gene:7417 VDAC2

OMIM:193245 VDAC2

UCSC:P45880 VDAC2

Reference Transcript

Other Identifiers

11748509_s_at

11756232_s_at

16706298

211662_PM_s_at

211662_s_at

2485777

2485778

2485779

2485780

2485781

2485783

3252578

3252583

3252584

3252585

3252587

3252588

3252589

3252590

3252591

3252594

3252595

3252596

3252598

3252601

3252604

3252606

3252607

3252608

3252609

3252610

37696_at

37697_s_at

7417

7928524

8042335

A_14_P112950

A_23_P75268

A_32_P41292

A_33_P3415037

GO:0000166

GO:0001669

GO:0005215

GO:0005515

GO:0005634

GO:0005739

GO:0005741

GO:0005929

GO:0006811

GO:0006820

GO:0007005

GO:0007339

GO:0008289

GO:0008308

GO:0012501

GO:0015288

GO:0015485

GO:0016020

GO:0022414

GO:0023052

GO:0031210

GO:0031410

GO:0031966

GO:0032272

GO:0042645

GO:0043226

GO:0046930

GO:0055085

GO:0061024

GO:0065003

GO:0097001

GO:0097225

GO:0097345

GO:0098656

GO:2001243

HMNXSV003044406

ILMN_2221066

L08666_at

PH_hs_0029855

TC10000485.hg

TC10002137.hg

g190199_3p_s_at

Participates

as a candidate of

PolyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

VDAC2 [mitochondrial outer membrane]

Inferred To

Porin2 [mitochondrial outer membrane] (Drosophila melanogaster)

PolyUb-VDAC2 [mitochondrial outer membrane] (Bos taurus)

PolyUb-VDAC2 [mitochondrial outer membrane] (Canis familiaris)

PolyUb-VDAC2 [mitochondrial outer membrane] (Gallus gallus)

PolyUb-VDAC2 [mitochondrial outer membrane] (Mus musculus)

PolyUb-VDAC2 [mitochondrial outer membrane] (Rattus norvegicus)

vdac-1 [mitochondrial outer membrane] (Caenorhabditis elegans)

POR1 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

CG31722 [mitochondrial outer membrane] (Drosophila melanogaster)

CG31722-B [mitochondrial outer membrane] (Drosophila melanogaster)

POR2 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

VDAC2 [mitochondrial outer membrane] (Sus scrofa)

wu:fa01a08 [mitochondrial outer membrane] (Danio rerio)

Homologues of PolyUb-VDAC2 [mitochondrial outer membrane] (Drosophila melanogaster)

Homologues of PolyUb-VDAC2 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

porin [mitochondrial outer membrane] (Drosophila melanogaster)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [mitochondrial outer membrane]) at unknown position

Modification

PolyUb [mitochondrial outer membrane]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001171752.1, NP_001171712.1, NP_001311017.1, NP_003366.2

OpenTargets

ENSG00000165637

GeneCards

P45880

HPA

ENSG00000165637-VDAC2

ZINC - Substances

VDAC2_HUMAN

ZINC target

P45880

Ensembl

ENST00000332211, ENSG00000165637, ENSP00000443092, ENSP00000361635, ENST00000313132, ENST00000543351, ENSP00000361686

PRO

P45880

Pharos - Targets

P45880

ZINC - Predictions - Purchasable

VDAC2_HUMAN

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	22
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	5
UniProt:P21796 VDAC1	4	VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624)	0.499	5
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2

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