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PolyUb-VDAC2 [mitochondrial outer membrane]
Stable Identifier
R-HSA-6783185
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
VDAC2, Voltage-dependent anion-selective channel protein 2, VDAC2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
USP30:PolyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
PolyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
PolyUb-VDAC2 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P45880 VDAC2
Gene Names
VDAC2
Chain
initiator methionine:, chain:2-294
Reference Genes
BioGPS Gene:7417 VDAC2
COSMIC (genes):VDAC2 VDAC2
CTD Gene:7417 VDAC2
dbSNP Gene:7417 VDAC2
ENSEMBL:ENSG00000165637 VDAC2
ENSEMBL_homo_sapiens_GENE:ENSG00000165637.14 VDAC2
HGNC:12672 VDAC2
KEGG Gene (Homo sapiens):7417 VDAC2
Monarch:7417 VDAC2
NCBI Gene:7417 VDAC2
OMIM:193245 VDAC2
UCSC:P45880 VDAC2
Reference Transcript
RefSeq:NM_001184823.1 VDAC2
RefSeq:NM_001184783.2 VDAC2
RefSeq:NM_003375.4 VDAC2
RefSeq:NM_001324088.1 VDAC2
Other Identifiers
11748509_s_at
11756232_s_at
16706298
211662_PM_s_at
211662_s_at
2485777
2485778
2485779
2485780
2485781
2485783
3252578
3252583
3252584
3252585
3252587
3252588
3252589
3252590
3252591
3252594
3252595
3252596
3252598
3252601
3252604
3252606
3252607
3252608
3252609
3252610
37696_at
37697_s_at
7417
7928524
8042335
A_14_P112950
A_23_P75268
A_32_P41292
A_33_P3415037
GO:0000166
GO:0001669
GO:0005215
GO:0005515
GO:0005634
GO:0005739
GO:0005741
GO:0005929
GO:0006811
GO:0006820
GO:0007005
GO:0007339
GO:0008142
GO:0008289
GO:0008308
GO:0012501
GO:0015288
GO:0015485
GO:0016020
GO:0022414
GO:0023052
GO:0031210
GO:0031410
GO:0031966
GO:0032272
GO:0042645
GO:0043226
GO:0043227
GO:0046930
GO:0055085
GO:0061024
GO:0065003
GO:0097001
GO:0097225
GO:0097345
GO:0098656
GO:2001243
HMNXSV003044406
ILMN_2221066
L08666_at
PH_hs_0029855
TC10000485.hg
TC10002137.hg
g190199_3p_s_at
Participates
as a candidate of
PolyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
p-S65-Ub:VDAC2 [mitochondrial outer membrane]
K63polyUb-VDAC2 [mitochondrial outer membrane]
K48polyUb-VDAC2 [mitochondrial outer membrane]
Ub-VDAC2 [mitochondrial outer membrane]
VDAC2 [mitochondrial outer membrane]
Inferred To
Porin2 [mitochondrial outer membrane]
(Drosophila melanogaster)
PolyUb-VDAC2 [mitochondrial outer membrane]
(Bos taurus)
PolyUb-VDAC2 [mitochondrial outer membrane]
(Gallus gallus)
PolyUb-VDAC2 [mitochondrial outer membrane]
(Mus musculus)
PolyUb-VDAC2 [mitochondrial outer membrane]
(Rattus norvegicus)
PolyUb-VDAC2 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
PolyUb-VDAC2 [mitochondrial outer membrane]
(Sus scrofa)
vdac-1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
CG31722 [mitochondrial outer membrane]
(Drosophila melanogaster)
CG31722-B [mitochondrial outer membrane]
(Drosophila melanogaster)
VDAC2 [mitochondrial outer membrane]
(Canis familiaris)
vdac2 [mitochondrial outer membrane]
(Danio rerio)
vdac2 [mitochondrial outer membrane]
(Xenopus tropicalis)
Homologues of PolyUb-VDAC2 [mitochondrial outer membrane]
(Drosophila melanogaster)
porin [mitochondrial outer membrane]
(Drosophila melanogaster)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [mitochondrial outer membrane]) at unknown position
Modification
PolyUb [mitochondrial outer membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001311017.1
,
NP_003366.2
,
NP_001171712.1
,
NP_001171752.1
OpenTargets
ENSG00000165637
GeneCards
P45880
ZINC - Substances
VDAC2_HUMAN
HPA
ENSG00000165637-VDAC2
ZINC target
P45880
Ensembl
ENST00000543351
,
ENST00000332211
,
ENSP00000443092
,
ENSP00000361686
,
ENST00000313132
,
ENSP00000361635
,
ENSG00000165637
PRO
P45880
Pharos - Targets
P45880
ZINC - Predictions - Purchasable
VDAC2_HUMAN
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
22
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.64
10
UniProt:P21796 VDAC1
7
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
0.623
6
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.556
3
UniProt:P49821 NDUFV1
1
NDUFV1 [mitochondrial inner membrane]
(R-HSA-163926)
0.556
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.536
2
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
2
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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