Reactome | NAMPT [cytosol]

NAMPT [cytosol]

Stable Identifier

R-HSA-197188

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NamPRT, Pre-B cell enhancing factor, PBEF_HUMAN, PBEF1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by NPAS4 (Homo sapiens)
      - NPAS4 regulates expression of target genes (Homo sapiens)
        
        NPAS4 stimulates NAMPT gene expression (Homo sapiens)
        
        NAMPT [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43490 NAMPT

Gene Names

NAMPT, PBEF, PBEF1

Chain

chain:1-491

Reference Genes

BioGPS Gene:10135 NAMPT

COSMIC (genes):NAMPT NAMPT

CTD Gene:10135 NAMPT

dbSNP Gene:10135 NAMPT

ENSEMBL:ENSG00000105835 NAMPT

HGNC:30092 NAMPT

KEGG:hsa:10135 NAMPT

Monarch:10135 NAMPT

NCBI Gene:10135 NAMPT

OMIM:608764 NAMPT

UCSC:P43490 NAMPT

Reference Transcript

Other Identifiers

10135

11743110_at

11743111_s_at

11760312_at

1555167_PM_s_at

1555167_s_at

16713318

17061545

217738_PM_at

217738_at

217739_PM_s_at

217739_s_at

236495_PM_at

236495_at

243296_PM_at

243296_at

3066821

3066822

3066823

3066824

3066825

3066826

3066827

3066828

3066829

3066830

3066831

3066832

3066833

3066834

3066835

3066836

3066837

3066840

3066841

3066842

3066844

3066845

3066846

3066847

3066848

3066849

3066850

3066851

3066852

3066853

3066854

3066855

3066856

3066857

3066858

3066859

3066860

3066863

3066864

3066865

3066866

3066867

3285327

3285328

3285329

3285330

3285331

3285332

3285333

3285335

33849_at

3658600

45256_at

64031_at

7933084

8142120

84950_at

A_23_P305060

A_24_P408772

A_33_P3364864

A_33_P3364869

A_33_P3375934

GE79862

GE844604

GE84666

GE86233

GE87583

GO:0003824

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0006355

GO:0007165

GO:0007267

GO:0007623

GO:0008284

GO:0009435

GO:0016607

GO:0016740

GO:0016757

GO:0019363

GO:0023052

GO:0030054

GO:0032922

GO:0034356

GO:0042802

GO:0043226

GO:0045944

GO:0047280

GO:0048018

GO:0048511

GO:0051770

GO:0055086

GO:0070062

GO:0098772

HMNXSV003007667

HMNXSV003048993

Hs.178784.0.A1_3p_at

Hs.239138.0.S2_3p_at

Hs.302232.0.A1_3p_at

Hs2.239138.2.S1_3p_s_at

ILMN_1653871

ILMN_1711832

ILMN_1737126

ILMN_1753111

PH_hs_0027356

TC07001738.hg

TC10001182.hg

U02020_at

g5031976_3p_a_at

Participates

as an output of

Inferred To

Nampt [cytosol] (Mus musculus)

NAMPT [cytosol] (Bos taurus)

NAMPT [cytosol] (Canis familiaris)

NAMPT [cytosol] (Gallus gallus)

NAMPT [cytosol] (Rattus norvegicus)

NAMPT [cytosol] (Sus scrofa)

NAMPT [cytosol] (Xenopus tropicalis)

Cross References

ZINC - Investigational

NAMPT_HUMAN

OpenTargets

ENSG00000105835

ENSEMBL

ENST00000681491, ENSP00000222553, ENSP00000506540, ENSP00000390591, ENSP00000506129, ENST00000222553, ENST00000424768, ENST00000681255

HPA

ENSG00000105835-NAMPT

ZINC - Substances

NAMPT_HUMAN

ZINC target

P43490

PRO

P43490

Pharos - Targets

P43490

GlyGen

P43490

ZINC - Predictions - Purchasable

NAMPT_HUMAN

HMDB Protein

HMDBP08864

PDB

4LWW, 6TA2, 6E68, 4O10, 5NSD, 4N9C, 4O13, 4N9E, 4O15, 8DSC, 2GVJ, 4L4L, 4KFO, 4JNM, 8DSI, 4WQ6, 4N9B, 8DSM, 2E5D, 2GVG, 2E5B, 4LVF, 4O1C, 3DKJ, 4O19, 4O1A, 4O17, 4M6P, 4O16, 4O28, 4L4M, 6B76, 7PPH, 7PPE, 6AZJ, 8F7L, 5UPE, 7PPF, 5U2N, 8IVU, 5U2M, 5WI0, 6ATB, 6PEB, 5LX3, 5WI1, 4O12, 4N9D, 5LX5, 4O14, 4LVD, 8DSE, 4KFP, 5KIT, 8DSH, 4LVB, 4LVA, 4LVG, 6TA0, 2E5C, 4O1D, 4O0Z, 3DKL, 3DHF, 4O1B, 4O18, 4M6Q, 3DHD, 4LV9, 4JR5, 7PPI, 7PPG, 8DSD, 6B75, 7ENQ, 8DTJ, 6TAC, 8TM7, 4KFN, 4LTS, 5UPF, 3DGR

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43490 NAMPT	1	NAMPT [cytosol] (R-HSA-197188)	0.743	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:Q70CQ1-2 USP49			0.556	3
UniProt:Q01628 IFITM3	1	IFITM3 [plasma membrane] (R-HSA-1015688)	0.508	3
UniProt:P02792 FTL	4	FTL [endocytic vesicle lumen] (R-HSA-2299671) FTL [extracellular region] (R-HSA-2187214) FTL [azurophil granule lumen] (R-HSA-6799149) FTL [cytosol] (R-HSA-434215)	0.508	3
UniProt:P03886 MT-ND1	1	MT-ND1 [mitochondrial inner membrane] (R-HSA-60551)	0.508	3