Reactome | DYNLL1 [tertiary granule membrane]

DYNLL1 [tertiary granule membrane]

Stable Identifier

R-HSA-6801482

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule membrane

Synonyms

DLC1, Dynein light chain 1, cytoplasmic, 8 kDa dynein light chain, DLC8, Protein inhibitor of neuronal nitric oxide synthase, PIN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P63167 DYNLL1

Gene Names

DYNLL1, DLC1, DNCL1, DNCLC1, HDLC1

Chain

chain:1-89

Reference Genes

BioGPS Gene:8655 DYNLL1

COSMIC - genes:DLC1 DYNLL1

COSMIC - genes:DYNLL1 DYNLL1

CTD Gene:8655 DYNLL1

dbSNP Gene:8655 DYNLL1

ENSEMBL:ENSG00000088986 DYNLL1

HGNC:15476 DYNLL1

KEGG:hsa:8655 DYNLL1

Monarch:8655 DYNLL1

NCBI Gene:8655 DYNLL1

OMIM:601562 DYNLL1

UCSC:P63167 DYNLL1

Reference Transcript

Other Identifiers

11753833_a_at

16757902

200703_PM_at

200703_at

3059785

3434394

3434396

3434398

3434401

3434402

3434403

3434404

3434405

3434406

3434407

3434408

3434409

3434410

34891_at

3574114

3574116

7959164

7980535

8655

A_14_P101015

A_14_P111801

A_23_P65031

A_24_P124672

GE61176

GO:0000776

GO:0004857

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005868

GO:0005874

GO:0005875

GO:0005886

GO:0005929

GO:0006915

GO:0006974

GO:0007017

GO:0007018

GO:0007286

GO:0008180

GO:0015630

GO:0016020

GO:0019899

GO:0021762

GO:0022414

GO:0030141

GO:0030235

GO:0030286

GO:0032388

GO:0035721

GO:0035774

GO:0035861

GO:0036487

GO:0042326

GO:0042802

GO:0043226

GO:0044458

GO:0044782

GO:0044877

GO:0045019

GO:0045505

GO:0048856

GO:0060703

GO:0070821

GO:0072686

GO:0097110

GO:0097542

GO:0098772

GO:0101003

GO:0110025

GO:0110027

GO:1904115

HMNXSV003054414

ILMN_2300186

PH_hs_0035324

TC12000946.hg

U32944_at

g4505812_3p_at

Participates

as a member of

Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)

Other forms of this molecule

DYNLL1 [cytosol]

DYNLL1 [plasma membrane]

DYNLL1 [ficolin-1-rich granule membrane]

DYNLL1 [cilium]

DYNLL1 [ciliary tip]

Inferred To

dlc-1 [tertiary granule membrane] (Caenorhabditis elegans)

dynll1 [tertiary granule membrane] (Xenopus tropicalis)

DYNLL1 [tertiary granule membrane] (Bos taurus)

DYNLL1 [tertiary granule membrane] (Canis familiaris)

DYNLL1 [tertiary granule membrane] (Plasmodium falciparum)

DYNLL1 [tertiary granule membrane] (Sus scrofa)

dlc2 [tertiary granule membrane] (Schizosaccharomyces pombe)

ctp [tertiary granule membrane] (Drosophila melanogaster)

DYL2 [tertiary granule membrane] (Gallus gallus)

Dynll1 [tertiary granule membrane] (Mus musculus)

Dynll1 [tertiary granule membrane] (Rattus norvegicus)

dlcB [tertiary granule membrane] (Dictyostelium discoideum)

DYN2 [tertiary granule membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_003737.1, NP_001032583.1, NP_001032584.1

OpenTargets

ENSG00000088986

ENSEMBL

ENSG00000088986, ENST00000548342, ENST00000392508, ENST00000242577, ENST00000392509, ENSP00000376296, ENSP00000376297, ENSP00000446614, ENSP00000242577, ENSP00000447907, ENST00000549989

GeneCards

DYNLL1

HPA

ENSG00000088986-DYNLL1

PRO

P63167

Pharos - Targets

P63167

GlyGen

P63167

HMDB Protein

HMDBP10685

PDB

3ZKE, 9BLY, 8PR0, 6GZL, 8PR1, 6GZJ, 3ZKF, 6SC2, 1CMI, 8PTK, 6RLB, 7D35, 8RGG

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.798	5
UniProt:Q9UBW7 ZMYM2	7	ZMYM2 [nucleoplasm] (R-HSA-9930820) ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.774	5
UniProt:O96015 DNAL4	1	DNAL4 [plasma membrane] (R-HSA-177484)	0.742	6
UniProt:O14867 BACH1	5	BACH1 [nucleoplasm] (R-HSA-9707688) BACH1 [cytosol] (R-HSA-9708429) PolyUb-BACH1 [nucleoplasm] (R-HSA-9708486) p-Y483 BACH1 [nucleoplasm] (R-HSA-9762202) p-Y483 BACH1 [cytosol] (R-HSA-9762206)	0.738	4
UniProt:Q9C0C7 AMBRA1	2	AMBRA1 [cytosol] (R-HSA-1632831) p-AMBRA1 [cytosol] (R-HSA-1632854)	0.725	4
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.725	4
UniProt:Q14678 KANK1	3	KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673593) p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673890) KANK1 [nucleoplasm] (R-HSA-9018640)	0.725	4
UniProt:P98170 XIAP	4	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-114444)	0.725	4
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.725	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.666	4
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.643	3
UniProt:O75330 HMMR	2	HMMR [cytosol] (R-HSA-8861624) HMMR [plasma membrane] (R-HSA-2160885)	0.643	3
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.643	3
UniProt:Q9H2P0 ADNP	1	ADNP [nucleoplasm] (R-HSA-9940393)	0.643	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.643	3
UniProt:P49023 PXN	4	p-Y31,Y118-PXN [cytosol] (R-HSA-5218693) PXN [cytosol] (R-HSA-210014) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493)	0.643	3
UniProt:Q9NR28 DIABLO	2	DIABLO [cytosol] (R-HSA-114298) DIABLO [mitochondrial intermembrane space] (R-HSA-64637)	0.638	3
UniProt:P63172 DYNLT1	4	DYNLT1 [ficolin-1-rich granule lumen] (R-HSA-6801487) DYNLT1 [extracellular region] (R-HSA-6806509) DYNLT1 [secretory granule lumen] (R-HSA-6801497) DYNLT1 [cytosol] (R-HSA-6801602)	0.638	3
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.632	6
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q6W0C5 DPPA3	2	DPPA3 [cytosol] (R-HSA-9818458) DPPA3 [nucleoplasm] (R-HSA-9817479)	0.556	5
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.527	2
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.527	2
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.527	2
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.527	2
UniProt:Q6PGQ7 BORA	3	p-7S,2T-BORA [cytosol] (R-HSA-4086411) p-8S,3T-BORA [cytosol] (R-HSA-3000330) BORA [cytosol] (R-HSA-2562607)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	4
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-325) [cytosol] (R-HSA-351892) STK24(326-443) [cytosol] (R-HSA-351898) STK24(1-325) [nucleoplasm] (R-HSA-351944)	0.527	2
UniProt:Q13426 XRCC4	2	XRCC4 [nucleoplasm] (R-HSA-75911) monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892)	0.527	2
UniProt:Q9P289 STK26	3	MST4 [cytosol] (R-HSA-351918) MST4(1-305) [cytosol] (R-HSA-351855) MST4(306-416) [cytosol] (R-HSA-351903)	0.527	2
UniProt:P29475 NOS1	1	NOS1 [cytosol] (R-HSA-419293)	0.527	2
UniProt:O43521 BCL2L11	7	BCL2L11 [cytosol] (R-HSA-2976673) p-BCL2L11 [cytosol] (R-HSA-140525) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674)	0.527	2
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.527	2
UniProt:P13861 PRKAR2A	2	PRKAR2A [cytosol] (R-HSA-57840) PRKAR2A [ciliary base] (R-HSA-5610412)	0.527	2
UniProt:Q14677 CLINT1	1	p-CLINT1 [cytosol] (R-HSA-429811)	0.508	2
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	8
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.483	2

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