Reactome | TNPO1 [cytosol]

TNPO1 [cytosol]

Stable Identifier

R-HSA-180743

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Importin beta-2, Transportin-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92973 TNPO1

Gene Names

TNPO1, KPNB2, MIP1, TRN

Chain

chain:1-898

Reference Genes

BioGPS Gene:3842 TNPO1

COSMIC (genes):TNPO1 TNPO1

CTD Gene:3842 TNPO1

dbSNP Gene:3842 TNPO1

ENSEMBL:ENSG00000083312 TNPO1

HGNC:6401 TNPO1

KEGG:hsa:3842 TNPO1

Monarch:3842 TNPO1

NCBI Gene:3842 TNPO1

OMIM:602901 TNPO1

UCSC:Q92973 TNPO1

Reference Transcript

Other Identifiers

11716619_a_at

11716620_a_at

11716621_a_at

11750370_a_at

11764082_at

16985992

207657_PM_x_at

207657_x_at

209225_PM_x_at

209225_x_at

209226_PM_s_at

209226_s_at

212635_PM_at

212635_at

221829_PM_s_at

221829_s_at

225765_PM_at

225765_at

225766_PM_s_at

225766_s_at

243324_PM_x_at

243324_x_at

2815044

2815045

2815050

2815051

2815052

2815054

2815060

2815061

2815062

2815063

2815064

2815066

2815069

2815076

2815077

2815078

2815081

2815082

2815083

2815084

2815086

2815089

2815090

2815091

2815092

2815093

2815095

2815096

2815098

2815099

2815102

2815104

2815105

2815106

2815107

2815111

2815112

2815113

2815114

2815115

2815116

2815118

2815126

3255443

3255449

3713374

3713375

3713376

3713377

3713387

3713391

3749236

3749238

3749241

3749243

3749244

3842

40463_at

40464_g_at

44048_at

61278_at

64950_at

73175_at

74519_s_at

74702_at

8106122

A_23_P156101

A_24_P260440

GE59368

GO:0003723

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005929

GO:0006606

GO:0006886

GO:0006913

GO:0008139

GO:0015031

GO:0031267

GO:0043226

GO:0061608

GO:0070062

GO:0140104

HMNXSV003020157

Hs.100235.0.A1_3p_at

Hs.100235.0.A1_3p_x_at

Hs.168075.1.A2_3p_a_at

Hs.168075.2.A1_3p_a_at

Hs.168075.2.A2_3p_a_at

Hs.21739.0.A1_3p_at

Hs2.292818.1.A1_3p_s_at

ILMN_1699820

ILMN_1763627

ILMN_1786347

ILMN_1837935

PH_hs_0037539

TC05000340.hg

U70322_at

Participates

as an input of

as a component of

as a member of

KPNB1,TNPO1 [cytosol] (Homo sapiens)

Other forms of this molecule

TNPO1 [cilium]

Inferred To

KAP104 [cytosol] (Saccharomyces cerevisiae)

Tnpo [cytosol] (Drosophila melanogaster)

kap104 [cytosol] (Schizosaccharomyces pombe)

tnpo1 [cytosol] (Xenopus tropicalis)

Tnpo1 [cytosol] (Mus musculus)

Tnpo1 [cytosol] (Rattus norvegicus)

tnpo [cytosol] (Dictyostelium discoideum)

TNPO1 [cytosol] (Bos taurus)

TNPO1 [cytosol] (Canis familiaris)

TNPO1 [cytosol] (Sus scrofa)

imb-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002261.3, NP_694858.1, XP_005248557.1

OpenTargets

ENSG00000083312

ENSEMBL

ENST00000506351, ENST00000337273, ENSP00000425118, ENSP00000336712, ENSP00000428899, ENST00000523768

HPA

ENSG00000083312-TNPO1

PRO

Q92973

Pharos - Targets

Q92973

GlyGen

Q92973

HMDB Protein

HMDBP08610

PDB

2Z5K, 5YVI, 5YVH, 5YVG, 2Z5J, 1QBK, 2H4M, 4JLQ, 4FQ3, 4FDD, 5J3V, 5TQC, 7VPW, 4OO6, 2Z5O, 2QMR, 2Z5N, 8SGH, 2OT8, 2Z5M, 7CYL

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.643	4
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.618	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.597	4
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.59	2
UniProt:P09651-2 HNRNPA1			0.558	2
IntAct:EBI-15631769 M9M			0.558	2
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.544	2
UniProt:Q96EY4 TMA16			0.527	3
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960)	0.508	2
UniProt:Q13151 HNRNPA0	1	HNRNPA0 [nucleoplasm] (R-HSA-71925)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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