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CAT [secretory granule lumen]
Stable Identifier
R-HSA-6801311
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Catalase apoprotein (EC 1.11.1.6), CATA_HUMAN, Catalase
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
CAT [secretory granule lumen] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10656833
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
Tainer, JA
,
Arvai, AS
,
Bourne, Y
,
Putnam, CD
J Mol Biol
2000
External Reference Information
External Reference
UniProt:P04040 CAT
Gene Names
CAT
Chain
initiator methionine:, chain:2-527
Reference Genes
BioGPS Gene:847 CAT
COSMIC (genes):CAT CAT
CTD Gene:847 CAT
dbSNP Gene:847 CAT
ENSEMBL:ENSG00000121691 CAT
ENSEMBL_homo_sapiens_GENE:ENSG00000121691.7 CAT
HGNC:1516 CAT
KEGG Gene (Homo sapiens):847 CAT
Monarch:847 CAT
NCBI Gene:847 CAT
OMIM:115500 CAT
UCSC:P04040 CAT
Reference Transcript
RefSeq:NM_001752.3 CAT
Other Identifiers
11732147_a_at
11732148_at
16723546
201432_PM_at
201432_at
211922_PM_s_at
211922_s_at
3326401
3326402
3326408
3326409
3326410
3326411
3326412
3326414
3326416
3326420
3326423
3326425
3326428
3326429
3326430
3326431
3326432
3326433
3326434
37009_at
7939298
847
A_23_P105138
GE61602
GO:0000302
GO:0001649
GO:0001657
GO:0001666
GO:0001822
GO:0003824
GO:0004046
GO:0004096
GO:0004601
GO:0005576
GO:0005615
GO:0005737
GO:0005739
GO:0005777
GO:0005778
GO:0005782
GO:0005829
GO:0005925
GO:0006091
GO:0006629
GO:0006641
GO:0006979
GO:0008203
GO:0009060
GO:0009410
GO:0009411
GO:0009636
GO:0009642
GO:0009650
GO:0010193
GO:0010288
GO:0012501
GO:0014823
GO:0014854
GO:0016020
GO:0016209
GO:0016491
GO:0016684
GO:0016787
GO:0019899
GO:0020027
GO:0020037
GO:0023052
GO:0030154
GO:0031410
GO:0032355
GO:0032868
GO:0032991
GO:0033189
GO:0033197
GO:0033591
GO:0034774
GO:0042542
GO:0042744
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0043231
GO:0045471
GO:0046686
GO:0046872
GO:0048856
GO:0050661
GO:0051781
GO:0051897
GO:0055093
GO:0061692
GO:0062151
GO:0070062
GO:0070542
GO:0071363
GO:0080184
GO:0098754
GO:0098869
GO:1904813
HMNXSV003031029
ILMN_1651705
ILMN_2151739
PH_hs_0018945
TC11000327.hg
X04085_rna1_at
g13562131_3p_s_at
g4557013_3p_at
Participates
as a member of
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
Other forms of this molecule
CAT [peroxisomal matrix]
CAT [ficolin-1-rich granule lumen]
CAT [extracellular region]
CAT [cytosol]
Inferred To
CAT [secretory granule lumen]
(Bos taurus)
CAT [secretory granule lumen]
(Caenorhabditis elegans)
CAT [secretory granule lumen]
(Canis familiaris)
CAT [secretory granule lumen]
(Danio rerio)
CAT [secretory granule lumen]
(Dictyostelium discoideum)
CAT [secretory granule lumen]
(Drosophila melanogaster)
CAT [secretory granule lumen]
(Gallus gallus)
CAT [secretory granule lumen]
(Mus musculus)
CAT [secretory granule lumen]
(Rattus norvegicus)
CAT [secretory granule lumen]
(Saccharomyces cerevisiae)
CAT [secretory granule lumen]
(Schizosaccharomyces pombe)
CAT [secretory granule lumen]
(Sus scrofa)
CAT [secretory granule lumen]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001743.1
Guide to Pharmacology - Targets
2979
OpenTargets
ENSG00000121691
GeneCards
P04040
HPA
ENSG00000121691-CAT
Ensembl
ENSG00000121691
,
ENST00000241052
,
ENSP00000241052
PRO
P04040
Pharos - Targets
P04040
Orphanet
15402
HMDB Protein
HMDBP01582
PDB
8EL9
,
7P8W
,
1DGG
,
1QQW
,
7VD9
,
1DGB
,
8SGV
,
1F4J
,
8HID
,
8PVD
,
1DGF
,
1DGH
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04040 CAT
5
CAT [peroxisomal matrix]
(R-HSA-51417)
CAT [ficolin-1-rich granule lumen]
(R-HSA-6801279)
CAT [extracellular region]
(R-HSA-6806458)
CAT [secretory granule lumen]
(R-HSA-6801311)
CAT [cytosol]
(R-HSA-9033141)
0.594
5
UniProt:Q2T9J0 TYSND1
4
TYSND1(111-566) [peroxisomal matrix]
(R-HSA-9033589)
TYSND1(1-110) [peroxisomal matrix]
(R-HSA-9033587)
TYSND1 [peroxisomal matrix]
(R-HSA-8933309)
TYSND1 [cytosol]
(R-HSA-9033586)
0.548
4
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.544
3
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
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