Reactome | SLC25A6 [mitochondrial intermembrane space]

SLC25A6 [mitochondrial intermembrane space]

Stable Identifier

R-HSA-1955374

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

ADP/ATP translocase 3 monomer, ADP,ATP carrier protein, liver isoform T2, adenine nucleotide translocator 3, ADP/ATP translocase 3, Adenine nucleotide translocator 3, ANT 3

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
12450408	The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae. De Marcos Lousa, C, Trézéguet, V, Dianoux, AC, Brandolin, G, Lauquin, GJ	Biochemistry	2002

External Reference Information

External Reference

UniProt:P12236 SLC25A6

Gene Names

SLC25A6, AAC3, ANT3, CDABP0051

Chain

chain:1-298, initiator methionine:1, chain:2-298

Reference Genes

COSMIC (genes):SLC25A6 SLC25A6

ENSEMBL:ENSG00000169100 SLC25A6

HGNC:10992 SLC25A6

UCSC:P12236 SLC25A6

Other Identifiers

11729584_a_at

11729585_x_at

17108705

17116720

212085_PM_at

212085_at

212826_PM_s_at

212826_s_at

293

3997375

3997376

3997377

3997378

3997379

3997380

3997381

3997385

3997386

3997387

3997388

3997390

3997391

4033176

4033177

4033178

4033179

4033180

4033181

4033182

4033186

4033187

4033188

4033189

4033191

4033192

40435_at

40436_g_at

8171111

8177003

88085_at

A_23_P33752

A_33_P3411397

A_33_P3589217

GO:0005471

GO:0005515

GO:0005634

GO:0005739

GO:0005743

GO:0005744

GO:0006915

GO:0015297

GO:0016020

GO:0055085

GO:0140021

GO:1901029

GO:1990544

HMNXSV003028977

Hs.164280.0.A1_3p_a_at

Hs.164280.1.A1_3p_at

J03592_at

PH_hs_0016939

TC0X000798.hg

TC0Y000115.hg

Participates

as a member of

Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial intermembrane space] (Homo sapiens)

Other forms of this molecule

SLC25A6 [mitochondrial inner membrane]

Cross References

Guide to Pharmacology - Targets

1064

ENSEMBL

ENSP00000518609, ENST00000711212, ENSP00000370808, ENST00000381401, ENSG00000169100, ENSG00000292334

OpenTargets

ENSG00000169100

HPA

ENSG00000169100-SLC25A6

PRO

P12236

Pharos - Targets

P12236

GlyGen

P12236

HMDB Protein

HMDBP03918

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63010 AP2B1	4	AP2B1 [cytosol] (R-HSA-182166) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [endolysosome membrane] (R-HSA-6784827)	0.666	4
UniProt:Q5JR59 MTUS2			0.666	4
UniProt:P0C0U1 PB1	2	PB1-F2 [mitochondrial intermembrane space] (R-FLU-5146789) PB1-F2 [cytosol] (R-FLU-169216)	0.591	5
UniProt:P12235 SLC25A4	3	SLC25A4 [mitochondrial intermembrane space] (R-HSA-1267984) SLC25A4 [cytosol] (R-HSA-1267975) AAC1 [mitochondrial inner membrane] (R-HSA-49741)	0.564	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.564	2
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.564	4
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q17R55 F187B			0.527	2
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.527	2
UniProt:O14498 ISLR	2	ISLR [extracellular region] (R-HSA-8848919) ISLR [platelet alpha granule lumen] (R-HSA-8848912)	0.527	3
UniProt:Q77M19 V			0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:P05141 SLC25A5	1	SLC25A5 [mitochondrial inner membrane] (R-HSA-49743)	0.527	2
UniProt:Q9UBP4 DKK3			0.527	2
UniProt:Q9Y279 VSIG4			0.527	2
UniProt:Q9HCL2 GPAM	1	GPAM(1-828) [mitochondrial outer membrane] (R-HSA-61855)	0.499	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	5
UniProt:A0A0F6B5H5 A0A0F6B5H5			0.462	2

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