Reactome | COPG1 [transport vesicle]

COPG1 [transport vesicle]

Stable Identifier

R-HSA-6808749

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle

Synonyms

Coatomer gamma subunit

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG1 [transport vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y678 COPG1

Gene Names

COPG1, COPG

Chain

chain:1-874

Reference Genes

BioGPS Gene:22820 COPG1

COSMIC (genes):COPG1 COPG1

CTD Gene:22820 COPG1

dbSNP Gene:22820 COPG1

ENSEMBL:ENSG00000181789 COPG1

HGNC:2236 COPG1

KEGG:hsa:22820 COPG1

Monarch:22820 COPG1

NCBI Gene:22820 COPG1

OMIM:615525 COPG1

UCSC:Q9Y678 COPG1

Reference Transcript

RefSeq:NM_016128.3 COPG1

Other Identifiers

11716855_a_at

16945320

217749_PM_at

217749_at

22820

2641533

2641534

2641536

2641537

2641538

2641539

2641540

2641541

2641542

2641543

2641544

2641545

2641546

2641547

2641548

2641549

2641550

2641552

2641553

2641554

2641555

2641556

2641557

2641558

2641559

2641560

2641563

2641564

2641565

2641566

2641567

2641568

2641569

2641570

2641571

2641572

2641573

2641574

2641575

2641576

2641578

48785_at

48787_g_at

52810_at

8082478

A_14_P104366

A_23_P44617

GE55889

GO:0000139

GO:0005198

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006891

GO:0007018

GO:0009306

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030126

GO:0030133

GO:0030663

GO:0031090

GO:0031410

GO:0043226

GO:0051683

GO:0072384

GO:0097708

HMNXSV003003676

HMNXSV003049966

ILMN_1708204

PH_hs_0032886

TC03000689.hg

g11559928_3p_at

g11559928_3p_x_at

Participates

as a member of

COPG1,2 [transport vesicle] (Homo sapiens)

Other forms of this molecule

COPG1 [endoplasmic reticulum membrane]

COPG1 [Golgi membrane]

COPG1 [cytosol]

Inferred To

SEC21 [transport vesicle] (Saccharomyces cerevisiae)

copg1 [transport vesicle] (Xenopus tropicalis)

copg-1 [transport vesicle] (Caenorhabditis elegans)

gammaCOP [transport vesicle] (Drosophila melanogaster)

copG [transport vesicle] (Dictyostelium discoideum)

COPG1 [transport vesicle] (Bos taurus)

COPG1 [transport vesicle] (Canis familiaris)

COPG1 [transport vesicle] (Gallus gallus)

COPG1 [transport vesicle] (Plasmodium falciparum)

COPG1 [transport vesicle] (Sus scrofa)

copg2 [transport vesicle] (Danio rerio)

Copg1 [transport vesicle] (Mus musculus)

Copg1 [transport vesicle] (Rattus norvegicus)

sec21 [transport vesicle] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENST00000314797, ENSP00000325002

OpenTargets

ENSG00000181789

HPA

ENSG00000181789-COPG1

PRO

Q9Y678

Pharos - Targets

Q9Y678

GlyGen

Q9Y678

HMDB Protein

HMDBP08335

PDB

1R4X

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.788	21
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.677	6
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.527	2

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