Reactome | ACLY [cytosol]

ACLY [cytosol]

Stable Identifier

R-HSA-76187

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

citrate lyase monomer, ATP citrate lyase, ATP-citrate synthase , ATP-citrate (pro-S-)-lyase, Citrate cleavage enzyme

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P53396 ACLY

Gene Names

ACLY

Chain

chain:1-1101

Reference Genes

BioGPS Gene:47 ACLY

COSMIC (genes):ACLY ACLY

CTD Gene:47 ACLY

dbSNP Gene:47 ACLY

ENSEMBL:ENSG00000131473 ACLY

ENSEMBL:ENSG00000131473.17 ACLY

HGNC:115 ACLY

KEGG Gene (Homo sapiens):47 ACLY

Monarch:47 ACLY

NCBI Gene:47 ACLY

OMIM:108728 ACLY

UCSC:P53396 ACLY

Reference Transcript

Other Identifiers

11720620_s_at

11720621_s_at

16844936

201127_PM_s_at

201127_s_at

201128_PM_s_at

201128_s_at

210337_PM_s_at

210337_s_at

3757434

3757435

3757436

3757437

3757439

3757440

3757444

3757445

3757446

3757449

3757450

3757451

3757452

3757454

3757456

3757457

3757458

3757460

3757463

3757465

3757468

3757470

3757471

3757473

3757474

3757476

3757478

3757479

3757481

3757482

3757484

40881_at

8015460

A_33_P3415042

GE59906

GO:0000166

GO:0003824

GO:0003878

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0006085

GO:0006091

GO:0006099

GO:0006101

GO:0006107

GO:0006629

GO:0006633

GO:0006695

GO:0006790

GO:0008610

GO:0015936

GO:0016020

GO:0016740

GO:0016829

GO:0031410

GO:0035578

GO:0043226

GO:0046872

GO:0046912

GO:0055086

GO:0070062

GO:1901135

GO:1904813

HMNXSV003013563

HMNXSV003042360

ILMN_1749014

ILMN_2371379

PH_hs_0028307

TC17001520.hg

X64330_at

g4501864_3p_s_at

g603073_3p_s_at

Participates

as a component of

ACLY tetramer [cytosol] (Homo sapiens)

Other forms of this molecule

ACLY [azurophil granule lumen]

ACLY [extracellular region]

ACLY [ficolin-1-rich granule lumen]

Inferred To

ATPCL [cytosol] (Drosophila melanogaster)

acly [cytosol] (Xenopus tropicalis)

ACLY [cytosol] (Bos taurus)

ACLY [cytosol] (Caenorhabditis elegans)

ACLY [cytosol] (Canis familiaris)

ACLY [cytosol] (Danio rerio)

ACLY [cytosol] (Dictyostelium discoideum)

ACLY [cytosol] (Gallus gallus)

ACLY [cytosol] (Mus musculus)

ACLY [cytosol] (Rattus norvegicus)

ACLY [cytosol] (Schizosaccharomyces pombe)

ACLY [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_942127.1, NP_001087.2, XP_005257452.1, NP_001290204.1, NP_001290203.1

Guide to Pharmacology - Targets

3245

OpenTargets

ENSG00000131473

ZINC - Substances

ACLY_HUMAN

ZINC - Biogenic

ACLY_HUMAN

ZINC target

P53396

PRO

P53396

PDB

6UUZ, 7LJ9, 5TES, 6UI9, 6UUW, 5TDE, 7LIW, 5TE1, 6HXK, 5TDZ, 5TEQ, 3PFF, 6HXH, 3MWE, 6POF, 6UIA, 3MWD, 5TDM, 6HXM, 6POE, 6QFB, 7LLA, 6O0H, 5TET, 6UV5, 6Z2H, 6HXL, 5TDF

ZINC - Metabolites

ACLY_HUMAN

GeneCards

P53396

HPA

ENSG00000131473-ACLY

Ensembl

ENST00000353196, ENST00000590151, ENST00000393896, ENSP00000466259, ENSP00000253792, ENSP00000345398, ENST00000352035, ENSP00000445349, ENSP00000377474, ENST00000537919, ENSG00000131473

Pharos - Targets

P53396

ZINC - Predictions - Purchasable

ACLY_HUMAN

HMDB Protein

HMDBP00010

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	13

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