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SNRNP200 [nucleoplasm]
Stable Identifier
R-HSA-71885
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
U5-200kDa helicase, U520_HUMAN, U5 small nuclear ribonucleoprotein 200 kDa helicase , U5 snRNP-specific 200 kDa protein, U5-200KD
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
mRNA Splicing - Minor Pathway (Homo sapiens)
ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)
ATAC C Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of AT-AC B Complex (Homo sapiens)
ATAC B Complex [nucleoplasm] (Homo sapiens)
U4 ATAC:U5:U6 ATAC Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
U4 ATAC:U5:U6 ATAC Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
Formation of AT-AC C complex (Homo sapiens)
ATAC B Complex [nucleoplasm] (Homo sapiens)
U4 ATAC:U5:U6 ATAC Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
ATAC C Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
SNRNP200 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75643 SNRNP200
Gene Names
SNRNP200, ASCC3L1, BRR2, HELIC2, KIAA0788
Chain
chain:1-2136
Reference Genes
BioGPS Gene:23020 SNRNP200
COSMIC (genes):SNRNP200 SNRNP200
CTD Gene:23020 SNRNP200
dbSNP Gene:23020 SNRNP200
ENSEMBL:ENSG00000144028 SNRNP200
HGNC:30859 SNRNP200
KEGG:hsa:23020 SNRNP200
Monarch:23020 SNRNP200
NCBI Gene:23020 SNRNP200
OMIM:601664 SNRNP200
UCSC:O75643 SNRNP200
Reference Transcript
RefSeq:XM_017003603.1 SNRNP200
RefSeq:NM_014014.4 SNRNP200
Other Identifiers
11744200_a_at
11744201_x_at
11749487_x_at
11752226_a_at
11752227_x_at
16656041
16656043
16656045
16656047
16656049
16656051
16656053
16656055
16656057
16656059
16656061
16656065
16656119
16900474
16900535
18670346
18670347
18670348
18670349
18670350
18670351
18670352
18670353
18670354
18670355
18670356
18670357
18670358
18670359
18670360
18670361
18670362
18670363
18670364
18670365
18670366
18670367
18670368
18670369
18670370
18670371
18670372
18670373
18670374
18670375
18670376
18670377
18670378
18670379
18670380
18670381
18670382
18670383
18670384
18670385
18670386
18670387
18670388
18670389
18670390
18670391
18670392
18670393
18670394
18670395
18670396
18670397
200058_PM_s_at
200058_s_at
214982_3p_at
214982_PM_at
214982_at
23020
232931_3p_at
232931_PM_at
232931_at
2564999
2565263
2565264
2565265
2565266
2565268
2565269
2565270
2565271
2565272
2565273
2565274
2565275
2565276
2565277
2565278
2565279
2565280
2565281
2565282
2565283
2565284
2565285
2565286
2565287
2565288
2565289
2565290
2565291
2565292
2565293
2565295
2565296
2565297
2565298
2565299
2565300
2565301
2565302
2565304
2565305
2565306
2565307
2565308
2565309
2565310
2565312
2565315
2565316
2565317
2565318
2565319
2565320
2565321
2565323
2565325
2565328
2565329
2565330
2565331
2565332
2565333
2565343
2565345
2565347
2565349
2565351
2565353
2565355
2565357
3731347
3731348
3731350
3731352
3731353
41224_at
47994_at
68805_f_at
7892596
7892678
7892718
7892747
7893056
7893070
7893485
7893676
7894329
7894350
7894358
7894438
7894470
7894653
7895476
7895857
7895882
7896186
7896230
7896484
7896565
7896646
80103_at
8053909
A_23_P131626
GE537622
GE80285
GO:0000354
GO:0000388
GO:0000398
GO:0001649
GO:0003676
GO:0003723
GO:0003724
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005681
GO:0005682
GO:0006397
GO:0008380
GO:0016020
GO:0016071
GO:0016787
GO:0016887
GO:0030154
GO:0042802
GO:0043226
GO:0046540
GO:0065003
GO:0071005
GO:0071006
GO:0071013
GO:0140098
GO:0140657
HMNXSV003001029
HMNXSV003016673
Hs.288494.0.S1_3p_at
Hs.288494.0.S1_3p_x_at
Hs.306592.0.S1_3p_at
ILMN_1705928
PH_hs_0013065
TC02002106.hg
TC02002107.hg
g12655128_3p_a_at
Participates
as a component of
U5 snRNP [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
Inferred To
SNRNP200 [nucleoplasm]
(Bos taurus)
SNRNP200 [nucleoplasm]
(Caenorhabditis elegans)
SNRNP200 [nucleoplasm]
(Dictyostelium discoideum)
SNRNP200 [nucleoplasm]
(Drosophila melanogaster)
SNRNP200 [nucleoplasm]
(Mus musculus)
SNRNP200 [nucleoplasm]
(Rattus norvegicus)
SNRNP200 [nucleoplasm]
(Schizosaccharomyces pombe)
snrnp200 [nucleoplasm]
(Danio rerio)
Ghost homologue of SNRNP200 [nucleoplasm]
(Canis familiaris)
Ghost homologue of SNRNP200 [nucleoplasm]
(Gallus gallus)
Ghost homologue of SNRNP200 [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of SNRNP200 [nucleoplasm]
(Sus scrofa)
Ghost homologue of SNRNP200 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016859092.1
,
NP_054733.2
OpenTargets
ENSG00000144028
ENSEMBL
ENST00000323853
,
ENSP00000317123
HPA
ENSG00000144028-SNRNP200
PRO
O75643
Pharos - Targets
O75643
Orphanet
SNRNP200
GlyGen
O75643
HMDB Protein
HMDBP11987
PDB
8C6J
,
8BC9
,
5YZG
,
8BCA
,
8BCD
,
8RC0
,
8H6K
,
5URJ
,
3JCR
,
8Q91
,
8QP9
,
8BCE
,
8BCG
,
5URM
,
4F93
,
8QOZ
,
4F91
,
8QPB
,
2Q0Z
,
8Q7V
,
7ABI
,
7BDJ
,
7BDL
,
8R0A
,
8Q7W
,
8R08
,
8CH6
,
8QO9
,
8QPK
,
7A5P
,
6S8O
,
6QDV
,
8R0B
,
6S8Q
,
8H6E
,
5Z57
,
6ICZ
,
8QZS
,
8BCC
,
7DVQ
,
8BCB
,
4KIT
,
5URK
,
8H6L
,
8H6J
,
6AH0
,
8BCF
,
8BCH
,
5O9Z
,
4F92
,
6QX9
,
8QPA
,
8QXD
,
6S9I
,
5Z58
,
8Q7Q
,
7BDK
,
7BDI
,
8RM5
,
8Y6O
,
8Q7X
,
6QW6
,
8R09
,
7OS1
,
6FF7
,
5XJC
,
8BC8
,
7OS2
,
7W5B
,
5Z56
,
7ABG
,
6AHD
,
7PX3
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O94906 PRPF6
1
PRPF6 [nucleoplasm]
(R-HSA-71881)
0.706
6
UniProt:O75554 WBP4
1
WBP4 [nucleoplasm]
(R-HSA-8867895)
0.688
11
UniProt:P14678 SNRPB
4
2xMe-SNRPB [cytosol]
(R-HSA-192218)
SNRPB [cytosol]
(R-HSA-191798)
Me2-R108,R112-SNRPB [nucleoplasm]
(R-HSA-192213)
SNRPB [nucleoplasm]
(R-HSA-71896)
0.669
4
UniProt:P62306 SNRPF
2
SNRPF [cytosol]
(R-HSA-191852)
SNRPF [nucleoplasm]
(R-HSA-71907)
0.643
4
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.597
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.589
2
UniProt:Q9CSN1 Snw1
1
Snw1 [nucleoplasm]
(R-MMU-2065315)
0.564
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.564
2
UniProt:P16383 GCFC2
1
GCFC2 [nucleoplasm]
(R-HSA-8869311)
0.527
2
UniProt:Q13523 PRPF4B
1
PRPF4B [nucleoplasm]
(R-HSA-9769525)
0.527
2
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:Q9BUQ8 DDX23
1
DDX23 [nucleoplasm]
(R-HSA-71879)
0.527
3
UniProt:P62304 SNRPE
2
SNRPE [cytosol]
(R-HSA-191782)
SNRPE [nucleoplasm]
(R-HSA-71905)
0.527
4
UniProt:O43290 SART1
1
SART1 [nucleoplasm]
(R-HSA-4615999)
0.508
5
UniProt:O15541 RNF113A
1
RNF113A [nucleoplasm]
(R-HSA-9769563)
0.508
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
7
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