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GARS [mitochondrial matrix]
Stable Identifier
R-HSA-379650
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Glycyl-tRNA synthetase
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Mitochondrial tRNA aminoacylation (Homo sapiens)
glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)
GARS dimer [mitochondrial matrix] (Homo sapiens)
GARS [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41250 GARS1
Gene Names
GARS1, GARS
Chain
transit peptide:1-36, chain:37-739
Reference Genes
BioGPS Gene:2617 GARS1
COSMIC (genes):GARS GARS1
CTD Gene:2617 GARS1
dbSNP Gene:2617 GARS1
ENSEMBL:ENSG00000106105 GARS
HGNC:4162 GARS1
Monarch:2617 GARS1
NCBI Gene:2617 GARS1
OMIM:600287 GARS1
UCSC:P41250 GARS1
Reference Transcript
RefSeq:NM_001316772.1 GARS1
RefSeq:NM_002047.3 GARS1
Other Identifiers
11753958_a_at
11757855_a_at
17044800
208693_PM_s_at
208693_s_at
2617
2995421
2995422
2995423
2995425
2995426
2995427
2995428
2995429
2995430
2995431
2995432
2995435
2995436
2995440
2995441
2995442
2995443
2995444
2995446
2995447
2995448
2995449
2995450
2995451
2995452
2995453
2995454
2995455
2995457
2995458
2995459
36581_at
36582_g_at
8132070
A_14_P100059
A_24_P154948
GE61267
GE86814
GO:0000166
GO:0003824
GO:0004081
GO:0004812
GO:0004820
GO:0005515
GO:0005524
GO:0005576
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0006399
GO:0006412
GO:0006418
GO:0006426
GO:0006520
GO:0015966
GO:0016740
GO:0016787
GO:0016874
GO:0030141
GO:0030424
GO:0031410
GO:0042802
GO:0042995
GO:0043226
GO:0046983
GO:0055086
GO:0070062
GO:0070150
GO:0140098
GO:0141192
HMNXSV003001952
ILMN_1771026
PH_hs_0015272
TC07000198.hg
U09510_s_at
U09587_at
g577711_3p_a_at
Participates
as a component of
GARS dimer [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
GARS(55-739) [cytosol]
Cross References
ENSEMBL
ENSP00000373918
,
ENST00000389266
OpenTargets
ENSG00000106105
IntEnz
6.1.1.14
HPA
ENSG00000106105-GARS1
PRO
P41250
Pharos - Targets
P41250
GlyGen
P41250
Orphanet
GARS1
HMDB Protein
HMDBP00565
PDB
4QEI
,
2ZT5
,
2ZT6
,
2ZT7
,
5E6M
,
4KQE
,
2ZT8
,
4KR3
,
2ZXF
,
4KR2
,
2PME
,
2PMF
,
2Q5I
,
2Q5H
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.556
3
UniProt:P17980 PSMC3
5
PSMC3 [cytosol]
(R-HSA-68774)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
0.527
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
11
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