Reactome | RAB7A [secretory granule membrane]

RAB7A [secretory granule membrane]

Stable Identifier

R-HSA-6804969

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Synonyms

Ras-related protein Rab-7a, RAB7A_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P51149 RAB7A

Gene Names

RAB7A, RAB7

Chain

initiator methionine:1, chain:2-207

Reference Genes

BioGPS Gene:7879 RAB7A

COSMIC (genes):RAB7A RAB7A

CTD Gene:7879 RAB7A

dbSNP Gene:7879 RAB7A

ENSEMBL:ENSG00000075785 RAB7A

HGNC:9788 RAB7A

KEGG Gene (Homo sapiens):7879 RAB7A

Monarch:7879 RAB7A

NCBI Gene:7879 RAB7A

OMIM:602298 RAB7A

UCSC:P51149 RAB7A

Reference Transcript

RefSeq:NM_004637.5 RAB7A

Other Identifiers

0001170731

11722811_s_at

11722812_s_at

11753390_x_at

16945241

211960_s_at

211961_s_at

2641264

2641285

2641287

2641288

2641293

2641294

2641295

2641296

2641297

2641298

2641300

2641301

2641302

2641303

2641304

2641305

7879

8082431

A_14_P133140

A_24_P234572

A_33_P3361851

GE62295

GO:0000045

GO:0000166

GO:0000421

GO:0002376

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005811

GO:0005829

GO:0005886

GO:0006605

GO:0006622

GO:0006629

GO:0006810

GO:0006897

GO:0006914

GO:0007034

GO:0007165

GO:0007174

GO:0008150

GO:0008333

GO:0009056

GO:0010008

GO:0015031

GO:0016020

GO:0016032

GO:0016042

GO:0016192

GO:0019003

GO:0019076

GO:0019886

GO:0022607

GO:0022615

GO:0030667

GO:0030670

GO:0030904

GO:0031410

GO:0031902

GO:0032419

GO:0032991

GO:0033162

GO:0040011

GO:0042147

GO:0042592

GO:0043167

GO:0043226

GO:0043312

GO:0044403

GO:0045022

GO:0045335

GO:0045732

GO:0048524

GO:0061024

GO:0061724

GO:0070062

GO:0090382

GO:0090383

GO:0090385

GO:1902586

GO:1903542

GO:1903543

GO:1905366

GO:1905394

Hs.237955.3.S1_3p_a_at

Hs.237955.3.S2_3p_at

ILMN_1716524

PH_hs_0017281

TC03000677.hg

X93499_at

Participant Of

hasMember

Secretory granule membrane proteins [secretory granule membrane]

Other forms of this molecule

GGC-RAB7A [lysosomal membrane]

GGC-RAB7A [cytosol]

RAB7A [lysosomal membrane]

RAB7A [phagocytic vesicle membrane]

RAB7A [cytosol]

RAB7A [plasma membrane]

Inferred To

rab-7 [secretory granule membrane] (Caenorhabditis elegans)

Rab7 [secretory granule membrane] (Drosophila melanogaster)

RAB7A [secretory granule membrane] (Canis familiaris)

RAB7A [secretory granule membrane] (Gallus gallus)

RAB7A [secretory granule membrane] (Plasmodium falciparum)

RAB7A [secretory granule membrane] (Sus scrofa)

rab7a [secretory granule membrane] (Danio rerio)

rab7a [secretory granule membrane] (Xenopus tropicalis)

ypt7 [secretory granule membrane] (Schizosaccharomyces pombe)

rab7A [secretory granule membrane] (Dictyostelium discoideum)

YPT7 [secretory granule membrane] (Saccharomyces cerevisiae)

Rab7a [secretory granule membrane] (Mus musculus)

Rab7a [secretory granule membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_004628.4

OpenTargets

ENSG00000075785

HPA

ENSG00000075785-RAB7A

GeneCards

P51149

Ensembl

ENSG00000075785, ENST00000265062, ENSP00000265062

PRO

P51149

Orphanet

15182

PDB

1YHN, 6IYB, 6WCW, 3LAW, 1T91

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96NA2 RILP	1	RILP [lysosomal membrane] (R-HSA-2213229)	0.861	8
UniProt:Q9BXW6 OSBPL1A	1	OSBPL1A [cytosol] (R-HSA-2213214)	0.672	5
UniProt:Q9GZS3 WDR61	2	WDR61 [nucleoplasm] (R-HSA-8866696) WDR61 [cytosol] (R-HSA-8931534)	0.556	3
UniProt:Q02535 ID3	1	ID3 [nucleoplasm] (R-HSA-9613379)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q32Q52 CL074			0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.556	3
UniProt:P31150 GDI1	1	GDI1 [cytosol] (R-HSA-195106)	0.527	2
UniProt:P0DTD1-PRO_0000449625 REP			0.527	2
UniProt:Q9Y4G2 PKHM1			0.463	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2

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