Reactome | XPOT [cytosol]

XPOT [cytosol]

Stable Identifier

R-HSA-6783484

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Exportin-T, XPOT_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43592 XPOT

Gene Names

XPOT

Chain

chain:1-962

Reference Genes

BioGPS Gene:11260 XPOT

COSMIC (genes):XPOT XPOT

CTD Gene:11260 XPOT

dbSNP Gene:11260 XPOT

ENSEMBL:ENSG00000184575 XPOT

ENSEMBL_homo_sapiens_GENE:ENSG00000184575.12 XPOT

HGNC:12826 XPOT

KEGG Gene (Homo sapiens):11260 XPOT

Monarch:11260 XPOT

NCBI Gene:11260 XPOT

OMIM:603180 XPOT

UCSC:O43592 XPOT

Reference Transcript

Other Identifiers

11260

11716831_at

16753465

212160_PM_at

212160_at

227117_PM_at

227117_at

3003309

3003311

3003313

3003315

3003316

3003317

3003324

3003325

3003328

3003331

3003332

3003333

3419808

3419809

3419810

3419812

3419813

3419815

3419816

3419817

3419818

3419819

3419820

3419821

3419822

3419825

3419826

3419827

3419828

3419829

3419830

3419831

3419832

3419833

3419834

3419835

3419836

3419837

3419838

3419839

3419844

3419846

3419847

3419848

3419850

3419851

3419852

3513739

38753_at

3903337

3903340

3903343

3903344

3903346

3903347

3903348

3903349

3903351

60502_at

7956785

86857_r_at

A_14_P106345

A_23_P340722

GE54336

GO:0000049

GO:0003723

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0006409

GO:0006886

GO:0006913

GO:0016363

GO:0031267

GO:0033036

GO:0043226

GO:0071528

GO:0071702

GO:0071705

HMNXSV003039041

Hs.18439.0.A1_3p_at

Hs.85951.0.S2_3p_at

ILMN_1743711

ILMN_2188374

TC12000569.hg

Participates

as an output of

tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)

Other forms of this molecule

XPOT [nucleoplasm]

Inferred To

xpo-3 [cytosol] (Caenorhabditis elegans)

Xpot [cytosol] (Mus musculus)

Xpot [cytosol] (Rattus norvegicus)

los1 [cytosol] (Schizosaccharomyces pombe)

LOS1 [cytosol] (Saccharomyces cerevisiae)

xpot [cytosol] (Danio rerio)

xpot [cytosol] (Dictyostelium discoideum)

xpot [cytosol] (Xenopus tropicalis)

XPOT [cytosol] (Bos taurus)

XPOT [cytosol] (Canis familiaris)

XPOT [cytosol] (Gallus gallus)

XPOT [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016874237.1, NP_009166.2

OpenTargets

ENSG00000184575

GeneCards

O43592

HPA

ENSG00000184575-XPOT

Ensembl

ENSG00000184575, ENSP00000327821, ENST00000332707

PRO

O43592

Pharos - Targets

O43592

HMDB Protein

HMDBP08622

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78424 PO6F2			0.556	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:Q13595 TRA2A			0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:P0DTC7 7a	5	7a [endolysosome membrane] (R-COV-9755945) 7a [endoplasmic reticulum membrane] (R-COV-9727308) 7a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694750) 7a [endocytic vesicle membrane] (R-COV-9694645) 7a [virion membrane] (R-COV-9694648)	0.527	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6

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