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XRCC6 [ficolin-1-rich granule lumen]
Stable Identifier
R-HSA-6801300
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule lumen
Synonyms
ATP-dependent DNA helicase II, 70 kDa subunit, KU70, Lupus Ku autoantigen protein p70, 70 kDa subunit of Ku antigen, Thyroid-lupus autoantigen, TLAA, CTC box binding factor 75 kDa subunit, CTCBF, CTC75
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
XRCC6 [ficolin-1-rich granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12956 XRCC6
Gene Names
XRCC6, G22P1
Chain
initiator methionine:, chain:2-609
Reference Genes
BioGPS Gene:2547 XRCC6
COSMIC (genes):XRCC6 XRCC6
CTD Gene:2547 XRCC6
dbSNP Gene:2547 XRCC6
ENSEMBL:ENSG00000196419 XRCC6
ENSEMBL_homo_sapiens_GENE:ENSG00000196419.13 XRCC6
HGNC:4055 XRCC6
KEGG Gene (Homo sapiens):2547 XRCC6
Monarch:2547 XRCC6
NCBI Gene:2547 XRCC6
OMIM:152690 XRCC6
UCSC:P12956 XRCC6
Reference Transcript
RefSeq:NM_001469.4 XRCC6
RefSeq:NM_001288976.1 XRCC6
RefSeq:NM_001288977.1 XRCC6
Other Identifiers
11730714_s_at
11754932_x_at
16930678
200792_PM_at
200792_at
2547
32766_at
3300572
3946972
3946973
3946974
3946975
3946976
3946978
3946981
3946982
3946984
3946987
3946989
3946990
3946993
3946994
3946995
3946997
3946998
3946999
4025651
4025653
4025659
4025661
4025663
8073457
A_23_P120942
GE61354
GE81028
GO:0000166
GO:0000723
GO:0000725
GO:0000781
GO:0000783
GO:0000976
GO:0002218
GO:0002376
GO:0003677
GO:0003678
GO:0003684
GO:0003690
GO:0003691
GO:0003723
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005829
GO:0005958
GO:0006266
GO:0006281
GO:0006303
GO:0006310
GO:0006351
GO:0006355
GO:0006974
GO:0008094
GO:0008152
GO:0010558
GO:0016020
GO:0016787
GO:0016829
GO:0016887
GO:0030154
GO:0030332
GO:0031410
GO:0032200
GO:0032508
GO:0032991
GO:0032993
GO:0034774
GO:0036211
GO:0042162
GO:0043226
GO:0043231
GO:0043564
GO:0044877
GO:0045027
GO:0045087
GO:0045621
GO:0045860
GO:0045892
GO:0045893
GO:0045944
GO:0048660
GO:0048856
GO:0051575
GO:0070418
GO:0070419
GO:0071475
GO:0071480
GO:0071481
GO:0097110
GO:0097680
GO:0098542
GO:0140097
GO:0140657
GO:1904813
HMNXSV003043756
ILMN_1743097
ILMN_2166506
J04611_at
PH_hs_0022800
TC22000339.hg
g4503840_3p_at
Participates
as a member of
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
Other forms of this molecule
XRCC6 [secretory granule lumen]
XRCC6 [extracellular region]
XRCC6 [cytosol]
XRCC6 [nucleoplasm]
Inferred To
ku70 [ficolin-1-rich granule lumen]
(Dictyostelium discoideum)
Irbp [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
xrcc6 [ficolin-1-rich granule lumen]
(Danio rerio)
xrcc6 [ficolin-1-rich granule lumen]
(Xenopus tropicalis)
XRCC6 [ficolin-1-rich granule lumen]
(Bos taurus)
XRCC6 [ficolin-1-rich granule lumen]
(Canis familiaris)
XRCC6 [ficolin-1-rich granule lumen]
(Gallus gallus)
XRCC6 [ficolin-1-rich granule lumen]
(Sus scrofa)
YKU70 [ficolin-1-rich granule lumen]
(Saccharomyces cerevisiae)
cku-70 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
pku70 [ficolin-1-rich granule lumen]
(Schizosaccharomyces pombe)
Xrcc6 [ficolin-1-rich granule lumen]
(Mus musculus)
Xrcc6 [ficolin-1-rich granule lumen]
(Rattus norvegicus)
Cross References
RefSeq
NP_001275906.1
,
NP_001275905.1
,
NP_001460.1
OpenTargets
ENSG00000196419
GeneCards
P12956
HPA
ENSG00000196419-XRCC6
Ensembl
ENSP00000384941
,
ENSP00000353192
,
ENSG00000196419
,
ENST00000360079
,
ENST00000359308
,
ENST00000405878
,
ENST00000402580
,
ENSP00000352257
,
ENSP00000384257
PRO
P12956
Pharos - Targets
P12956
PDB
8AG4
,
1JEY
,
7K1K
,
8EZA
,
8BOT
,
7K1J
,
6ERG
,
7LT3
,
7ZYG
,
7ZT6
,
7SU3
,
7LSY
,
6ERH
,
7ZWA
,
8BH3
,
6ERF
,
7AXZ
,
1JEQ
,
8BHY
,
7K0Y
,
3RZX
,
7NFE
,
5Y3R
,
1JJR
,
7NFC
,
7ZVT
,
6ZHE
,
7Z6O
,
8ASC
,
8BHV
,
6ZHA
,
7SGL
,
8EZB
,
7K1N
,
8AG5
,
7Z87
,
7Z88
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14191 WRN
2
monoSUMO1-K356,K496,K898-WRN [nucleoplasm]
(R-HSA-4568904)
WRN [nucleoplasm]
(R-HSA-67387)
0.897
10
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
0.896
8
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.853
9
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.703
21
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.667
7
UniProt:Q13426 XRCC4
2
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
XRCC4 [nucleoplasm]
(R-HSA-75911)
0.656
3
UniProt:Q01831 XPC
5
XPC [nucleoplasm]
(R-HSA-67441)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
0.643
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
13
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
2
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
2
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.527
2
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.527
2
UniProt:Q96P48 ARAP1
2
ARAP1 [cytosol]
(R-HSA-3211582)
p-Y231-ARAP1 [cytosol]
(R-HSA-8848869)
0.508
2
UniProt:P21796 VDAC1
7
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
0.483
3
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.483
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.462
3
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.462
2
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