Reactome | PHB2 [mitochondrial inner membrane]

PHB2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-8953721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Prohibitin-2, PHB2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99623 PHB2

Gene Names

PHB2, BAP, REA

Chain

initiator methionine:1, chain:2-299

Reference Genes

BioGPS Gene:11331 PHB2

COSMIC (genes):PHB2 PHB2

CTD Gene:11331 PHB2

dbSNP Gene:11331 PHB2

ENSEMBL:ENSG00000215021 PHB2

HGNC:30306 PHB2

KEGG:hsa:11331 PHB2

Monarch:11331 PHB2

NCBI Gene:11331 PHB2

OMIM:610704 PHB2

UCSC:Q99623 PHB2

Reference Transcript

Other Identifiers

11331

11715383_a_at

11715384_x_at

11753313_a_at

16760649

17118890

201600_PM_at

201600_at

3442397

3442398

3442399

3442400

3442401

3442402

3442403

3442404

3442405

3442406

3442407

3442408

3442409

3442410

3442411

3442412

3442413

3442414

3442415

3442416

3442417

3442418

3442419

3442420

3442421

3442422

3442423

3442424

37364_at

7960716

7960728

A_23_P151106

A_33_P3224307

A_33_P3368328

GE54942

GO:0000423

GO:0002376

GO:0002639

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005886

GO:0006355

GO:0006396

GO:0006606

GO:0006886

GO:0006913

GO:0006914

GO:0007005

GO:0007062

GO:0008289

GO:0009986

GO:0016020

GO:0016363

GO:0016477

GO:0030331

GO:0030520

GO:0032991

GO:0033147

GO:0033218

GO:0033598

GO:0033600

GO:0035632

GO:0039529

GO:0042113

GO:0042802

GO:0042803

GO:0043066

GO:0043433

GO:0045892

GO:0046625

GO:0046982

GO:0048856

GO:0048870

GO:0050821

GO:0051091

GO:0060744

GO:0060749

GO:0060762

GO:0070374

GO:0071944

GO:0098800

GO:0140374

GO:1900208

GO:1901224

GO:1904959

HMNXSV003014427

HMNXSV003058162

ILMN_1696087

PH_hs_0025971

RNA33415|snoRNA_scaRNA_8_270

TC12001153.hg

TC12001154.hg

TC12002730.hg

U72511_at

U72512_at

g6005853_3p_at

Participates

as a component of

Inferred To

phb2b [mitochondrial inner membrane] (Danio rerio)

phb2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

phb-2 [mitochondrial inner membrane] (Caenorhabditis elegans)

phbB [mitochondrial inner membrane] (Dictyostelium discoideum)

PHB2 [mitochondrial inner membrane] (Bos taurus)

PHB2 [mitochondrial inner membrane] (Canis familiaris)

PHB2 [mitochondrial inner membrane] (Gallus gallus)

PHB2 [mitochondrial inner membrane] (Plasmodium falciparum)

PHB2 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

PHB2 [mitochondrial inner membrane] (Sus scrofa)

Phb2 [mitochondrial inner membrane] (Drosophila melanogaster)

Phb2 [mitochondrial inner membrane] (Mus musculus)

Phb2 [mitochondrial inner membrane] (Rattus norvegicus)

Ghost homologue of PHB2 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001254629.1, NP_001138303.1

ENSEMBL

ENSG00000215021, ENSP00000441875, ENST00000535923, ENST00000440277, ENSP00000412856

OpenTargets

ENSG00000215021

GeneCards

PHB2

HPA

ENSG00000215021-PHB2

PRO

Q99623

Pharos - Targets

Q99623

GlyGen

Q99623

PDB

6IQE, 8J4I, 8RRH

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35232 PHB1	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.589	3
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.527	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.508	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12