Reactome | SSR1 [endoplasmic reticulum membrane]

SSR1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-444588

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Trap alpha, Translocon-associated protein subunit alpha, SSRA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43307 SSR1

Gene Names

SSR1, TRAPA, PSEC0262

Chain

signal peptide:1-18, chain:19-286

Reference Genes

BioGPS Gene:6745 SSR1

COSMIC (genes):SSR1 SSR1

CTD Gene:6745 SSR1

dbSNP Gene:6745 SSR1

ENSEMBL:ENSG00000124783 SSR1

HGNC:11323 SSR1

KEGG:hsa:6745 SSR1

Monarch:6745 SSR1

NCBI Gene:6745 SSR1

OMIM:600868 SSR1

UCSC:P43307 SSR1

Reference Transcript

Other Identifiers

11717051_s_at

11717052_at

11717053_a_at

11717054_a_at

11752611_s_at

11757542_s_at

11763739_s_at

11763972_at

17015388

200889_PM_s_at

200889_s_at

200890_PM_s_at

200890_s_at

200891_PM_s_at

200891_s_at

201894_PM_s_at

201894_s_at

225435_PM_at

225435_at

226712_PM_at

226712_at

2940552

2940553

2940554

2940555

2940556

2940557

2940558

2940559

2940560

2940561

2940564

2940565

2940566

2940567

2940568

2940569

2940570

2940571

2940574

2940575

2940580

2940581

2940583

2940584

2940585

2940586

2940587

2940588

2940589

2940590

2940592

2940594

2940603

34648_at

34649_at

56150_at

6745

8123767

88739_at

A_24_P544882

A_32_P89755

A_33_P3377060

A_33_P3396692

GE61252

GE87468

GE88767

GO:0005515

GO:0005783

GO:0005789

GO:0006613

GO:0008284

GO:0016020

GO:0043226

HMNXSV003037224

Hs.101810.0.S1_3p_at

Hs.250773.0.S1_3p_a_at

Hs.250773.0.S1_3p_s_at

Hs.250773.0.S2_3p_a_at

Hs.288963.0.S1_3p_at

ILMN_1750693

M14219_at

PH_hs_0005659

PH_hs_0013283

TC06004107.hg

Z12830_at

g4503270_3p_s_at

g6552340_3p_a_at

Participates

as an output of

Expression of SSR1 (Trap alpha) (Homo sapiens)

as a component of

TRAP Complex [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSP00000244763, ENST00000244763

OpenTargets

ENSG00000124783

HPA

ENSG00000124783-SSR1

PRO

P43307

Pharos - Targets

P43307

GlyGen

P43307

HMDB Protein

HMDBP08009

PDB

8B6L

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.773	7
UniProt:P60468 SEC61B	3	SEC61B [cytosol] (R-HSA-5250571) SEC61B [endoplasmic reticulum membrane] (R-HSA-264899) SEC61B [phagocytic vesicle membrane] (R-HSA-1236882)	0.564	2
UniProt:P01009 SERPINA1	8	SERPINA1 [endoplasmic reticulum lumen] (R-HSA-8956709) p-SERPINA1 [endoplasmic reticulum lumen] (R-HSA-8957062) SERPINA1 [ficolin-1-rich granule lumen] (R-HSA-6804783) SERPINA1 [extracellular region] (R-HSA-141757) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (R-HSA-5689435) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689731) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689734) SERPINA1 [platelet alpha granule lumen] (R-HSA-141755)	0.524	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9