Reactome | GNAI2 [plasma membrane]

GNAI2 [plasma membrane]

Stable Identifier

R-HSA-55435

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G(i), alpha-2 subunit, Adenylate cyclase-inhibiting G alpha protein

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - ADP signalling through P2Y purinoceptor 12 (Homo sapiens)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
      - Gi activation by P2Y purinoceptor 12 (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04899 GNAI2

Gene Names

GNAI2, GNAI2B

Chain

initiator methionine:, chain:2-355

Reference Genes

COSMIC (genes):GNAI2 GNAI2

dbSNP Gene:2771 GNAI2

ENSEMBL:ENSG00000114353 GNAI2

Participates

as a candidate of

G alpha (i,o) (candidates) [plasma membrane] (Homo sapiens)

as a member of

G alpha (i) [plasma membrane] (Homo sapiens)

Inferred To

GNAI2 [plasma membrane] (Bos taurus)

GNAI2 [plasma membrane] (Canis familiaris)

GNAI2 [plasma membrane] (Dictyostelium discoideum)

GNAI2 [plasma membrane] (Gallus gallus)

GNAI2 [plasma membrane] (Sus scrofa)

GNAZ [plasma membrane] (Saccharomyces cerevisiae)

GNAZ [plasma membrane] (Schizosaccharomyces pombe)

Gnai2 [plasma membrane] (Mus musculus)

gnai2b [plasma membrane] (Danio rerio)

gnai2 [plasma membrane] (Xenopus tropicalis)

G(i), alpha-2 subunit [plasma membrane] (Rattus norvegicus)

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32302 CXCR5	1	CXCR5 [plasma membrane] (R-HSA-444505)	0.718	7
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	13
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P42866 Oprm1	2	Oprm1 [plasma membrane] (R-MMU-60951) Oprm1 [plasma membrane] (R-MMU-9017924)	0.524	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.483	2

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