DSG2(?-1118)

Stable Identifier
R-HSA-351839
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Desmoglein 2 (70 Kd fragment)
Locations in the PathwayBrowser
Summation

The caspase 3-mediated proteolytic processing of full-length Dsg2, the most widespread desmosomal cadherin, results in disappearance of Dsg2 from the cell surface and appearance of a 70-kDa fragment in the cytosol. Loss of Dsg2 from the cell surface may contribute to the progressive loss of intercellular adhesion strength during apoptosis (Cirillo et al., 2008)

External Reference Information
External Reference
Gene Names
DSG2, CDHF5
Chain
signal peptide:1-23, propeptide:24-49, chain:50-1118
Reference Transcript
Other Identifiers
0004570706
11725523_at
11725524_s_at
11725525_at
1553105_s_at
16851768
1829
217901_at
25122
2YQG
33468_at
3783530
3783531
3783532
3783539
3783540
3783541
3783542
3783543
3783545
3783547
3783548
3783549
3783550
3783551
3783552
3783553
3783554
3783555
3783556
3783557
3783558
3783559
3783560
3783561
3783562
4896
52016_at
5ERD
5J5J
75487_at
8020779
A_14_P200506
A_23_P141730
AAH99655
AAH99656
AAH99657
BC099655
BC099656
BC099657
CAA81226
CAB025122
CCDS42423
DSG2
DSG2-201
ENSG00000046604
ENSP00000261590
ENST00000261590
EntrezGene:1829
GE60381
GO:0000003
GO:0001533
GO:0002934
GO:0003013
GO:0003165
GO:0003674
GO:0005509
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005886
GO:0005911
GO:0007155
GO:0007156
GO:0008150
GO:0008219
GO:0009986
GO:0014704
GO:0016020
GO:0016021
GO:0016324
GO:0016328
GO:0030054
GO:0030057
GO:0030154
GO:0031424
GO:0032570
GO:0034330
GO:0043167
GO:0043226
GO:0043231
GO:0046872
GO:0048856
GO:0050839
GO:0060135
GO:0070062
GO:0070268
GO:0086073
GO:0086083
GO:0086091
GO:0098911
HGNC:3049
HPA004896
Hs.2631.0.A2_3p_at
Hs2.359784.1.S1_3p_s_at
ILMN_1704196
ILMN_3251672
IPR002126
IPR009122
IPR009123
IPR013783
IPR015919
IPR020894
IPR027397
J3KSI6
LRG_397
MIM:125671
MIM:610193
MIM:612877
NM_001943
NP_001934
PF00028
PH_hs_0024907
PR00205
PR01818
PR01819
SM00112
TC18000128.hg
uc002kwu.5
UPI0000048E38
Z26317
Z26317_at
Participant Of
Other forms of this molecule
Inferred To
Cross References
RefSeq
GeneCards
PRO
Orphanet
HMDB Protein
PDB