Reactome | FLOT1 [plasma membrane]

FLOT1 [plasma membrane]

Stable Identifier

R-HSA-112174

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Flotillin, Flotillin-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75955 FLOT1

Gene Names

FLOT1

Chain

chain:1-427

Reference Genes

BioGPS Gene:10211 FLOT1

COSMIC (genes):FLOT1 FLOT1

CTD Gene:10211 FLOT1

dbSNP Gene:10211 FLOT1

ENSEMBL:ENSG00000137312 FLOT1

ENSEMBL_homo_sapiens_GENE:ENSG00000137312.15 FLOT1

ENSEMBL_homo_sapiens_GENE:ENSG00000206379.12 FLOT1

ENSEMBL_homo_sapiens_GENE:ENSG00000206480.11 FLOT1

ENSEMBL_homo_sapiens_GENE:ENSG00000230143.9 FLOT1

ENSEMBL_homo_sapiens_GENE:ENSG00000232280.9 FLOT1

HGNC:3757 FLOT1

KEGG Gene (Homo sapiens):10211 FLOT1

Monarch:10211 FLOT1

NCBI Gene:10211 FLOT1

OMIM:606998 FLOT1

Reference Transcript

Other Identifiers

10211

11743045_a_at

11743046_a_at

11743047_x_at

11748081_a_at

11748082_x_at

11757316_a_at

17016995

17026737

17028888

17031666

17034121

17034129

17036388

17039163

17041731

208748_PM_s_at

208748_s_at

208749_PM_x_at

208749_x_at

210142_PM_x_at

210142_x_at

2948595

2948596

2948597

2948598

2948599

2948601

2948602

2948603

2948604

2948606

2948607

2948611

2948613

2948615

2948618

2948620

2948622

2948625

2948629

40635_at

8124828

8178419

8179688

A_23_P214603

GE61098

GO:0001819

GO:0001931

GO:0001934

GO:0002020

GO:0002090

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005815

GO:0005856

GO:0005886

GO:0005901

GO:0005911

GO:0005912

GO:0005925

GO:0007155

GO:0007409

GO:0008180

GO:0009897

GO:0016020

GO:0016192

GO:0016323

GO:0016600

GO:0022617

GO:0023052

GO:0030027

GO:0030154

GO:0030198

GO:0030864

GO:0031410

GO:0032092

GO:0032226

GO:0032728

GO:0033227

GO:0034116

GO:0034141

GO:0034330

GO:0034451

GO:0034976

GO:0035023

GO:0035255

GO:0036211

GO:0042383

GO:0042470

GO:0043123

GO:0043226

GO:0044291

GO:0044853

GO:0044854

GO:0044857

GO:0045121

GO:0045202

GO:0045807

GO:0048643

GO:0048786

GO:0048856

GO:0050821

GO:0051580

GO:0061024

GO:0070062

GO:0070528

GO:0071360

GO:0072659

GO:0098542

GO:0098691

GO:0098793

GO:0098978

GO:0098982

GO:1901741

GO:1901890

GO:2000049

HMNXSV003004658

Hs.179986.0.A1_3p_a_at

ILMN_1661439

PH_hs_0010655

TC06001508.hg

TC6_apd_hap1000078.hg

TC6_cox_hap2000142.hg

TC6_dbb_hap3000131.hg

TC6_mann_hap4000120.hg

TC6_mcf_hap5000121.hg

TC6_qbl_hap6000132.hg

TC6_ssto_hap7000122.hg

g5114048_3p_a_at

Participates

as a candidate of

as a component of

FLOT1:FLOT2 [plasma membrane] (Homo sapiens)

Inferred To

FLOT1 [plasma membrane] (Bos taurus)

FLOT1 [plasma membrane] (Canis familiaris)

FLOT1 [plasma membrane] (Gallus gallus)

FLOT1 [plasma membrane] (Sus scrofa)

Flot1 [plasma membrane] (Mus musculus)

Flot1 [plasma membrane] (Rattus norvegicus)

flot1 [plasma membrane] (Xenopus tropicalis)

flot1a [plasma membrane] (Danio rerio)

Flo1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001305804.1, XP_005248837.1, NP_005794.1

OpenTargets

ENSG00000137312

GeneCards

O75955

HPA

ENSG00000137312-FLOT1

Ensembl

ENST00000376389, ENST00000436822, ENSP00000372873, ENSG00000230143, ENSG00000206480, ENSP00000365569, ENSP00000388861, ENSG00000137312, ENSG00000232280, ENSP00000373056, ENSG00000206379, ENST00000383382, ENSP00000391438, ENST00000444632, ENST00000383562

PRO

O75955

Pharos - Targets

O75955

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.581	5
UniProt:O95477 ABCA1	11	ABCA1 W590S [plasma membrane] (R-HSA-5682201) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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