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ADRM1 [nucleoplasm]
Stable Identifier
R-HSA-9918361
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasomal ubiquitin receptor ADRM1, ADRM1_HUMAN, Rpn13 homolog
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Independent G1/S DNA Damage Checkpoint (Homo sapiens)
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Circadian clock (Homo sapiens)
Degradation of CRY and PER proteins (Homo sapiens)
Proteolysis of K48polyUb,p-S-CRY1,2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
ADRM1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16186 ADRM1
Gene Names
ADRM1, GP110
Chain
initiator methionine:1, chain:2-407
Reference Genes
BioGPS Gene:11047 ADRM1
COSMIC (genes):ADRM1 ADRM1
CTD Gene:11047 ADRM1
dbSNP Gene:11047 ADRM1
ENSEMBL:ENSG00000130706 ADRM1
HGNC:15759 ADRM1
KEGG:hsa:11047 ADRM1
Monarch:11047 ADRM1
NCBI Entrez Gene:11047 ADRM1
OMIM:610650 ADRM1
UCSC:Q16186 ADRM1
Reference Transcript
RefSeq:NM_007002.3 ADRM1
RefSeq:NM_175573.2 ADRM1
RefSeq:XM_005260257.1 ADRM1
RefSeq:NM_001281438.1 ADRM1
RefSeq:NM_001281437.1 ADRM1
Other Identifiers
11047
11716498_s_at
11716499_x_at
11750079_a_at
16915656
201281_PM_at
201281_at
38808_at
3892610
3892611
3892612
3892613
3892614
3892615
3892616
3892617
3892618
3892620
3892621
3892622
3892628
3892633
3892634
3892635
3892636
3892637
3892638
3892639
3892641
3892642
3892644
3892646
3892647
3892648
8063893
A_14_P126714
A_14_P200578
A_23_P68665
A_24_P305597
D64154_at
GE57289
GO:0000502
GO:0002020
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006368
GO:0008541
GO:0030163
GO:0043161
GO:0043248
GO:0061133
GO:0065003
GO:0070628
GO:0098772
GO:0140678
HMNXSV003021553
ILMN_1760143
ILMN_2389013
PH_hs_0005036
TC20000487.hg
g5901959_3p_at
Participates
as a component of
19S RP base [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ADRM1 [cytosol]
Inferred To
Adrm1 [nucleoplasm]
(Mus musculus)
Adrm1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of ADRM1 [nucleoplasm]
(Saccharomyces cerevisiae)
rpn1301 [nucleoplasm]
(Schizosaccharomyces pombe)
ADRM1 [nucleoplasm]
(Bos taurus)
ADRM1 [nucleoplasm]
(Canis familiaris)
ADRM1 [nucleoplasm]
(Gallus gallus)
ADRM1 [nucleoplasm]
(Sus scrofa)
adrm1 [nucleoplasm]
(Xenopus tropicalis)
adrm1b [nucleoplasm]
(Danio rerio)
adrm1-2 [nucleoplasm]
(Dictyostelium discoideum)
rpn-13 [nucleoplasm]
(Caenorhabditis elegans)
Rpn13 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_008933.2
,
NP_001268366.1
,
NP_783163.1
,
XP_005260314.1
,
NP_001268367.1
ENSEMBL
ENSP00000478877
,
ENSG00000130706
,
ENST00000253003
,
ENST00000491935
,
ENSP00000253003
OpenTargets
ENSG00000130706
GeneCards
ADRM1
HPA
ENSG00000130706-ADRM1
PRO
Q16186
Pharos - Targets
Q16186
GlyGen
Q16186
PDB
6UYJ
,
6CO4
,
2NBV
,
6UYI
,
8FTQ
,
5IRS
,
2KQZ
,
5YMY
,
4WLR
,
5V1Z
,
2L5V
,
6OI4
,
5V1Y
,
2KR0
,
4WLQ
,
4UEM
,
7KXI
,
4UEL
,
2MKZ
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.965
24
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.788
7
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.764
6
UniProt:Q99460 PSMD1
4
PSMD1 [extracellular region]
(R-HSA-6806194)
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [cytosol]
(R-HSA-68786)
0.75
7
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.744
6
UniProt:P51665 PSMD7
5
PSMD7 [cytosol]
(R-HSA-68806)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
0.725
5
UniProt:P62195 PSMC5
2
PSMC5 [cytosol]
(R-HSA-68780)
PSMC5 [nucleoplasm]
(R-HSA-174312)
0.725
6
UniProt:O00487 PSMD14
5
PSMD14 [cytosol]
(R-HSA-68722)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
0.725
5
UniProt:P17980 PSMC3
5
PSMC3 [cytosol]
(R-HSA-68774)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
0.725
6
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.713
5
IntAct:EBI-4399559 UBIQ
0.709
4
UniProt:P48556 PSMD8
2
PSMD8 [cytosol]
(R-HSA-68808)
PSMD8 [nucleoplasm]
(R-HSA-174318)
0.643
4
UniProt:Q15008 PSMD6
5
PSMD6 [cytosol]
(R-HSA-68804)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
0.643
4
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.643
4
UniProt:P43686 PSMC4
2
PSMC4 [nucleoplasm]
(R-HSA-174315)
PSMC4 [cytosol]
(R-HSA-68777)
0.643
5
UniProt:P35998 PSMC2
5
PSMC2 [cytosol]
(R-HSA-68771)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
0.643
5
UniProt:O43242 PSMD3
5
PSMD3 [cytosol]
(R-HSA-68798)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
0.643
4
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.643
5
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.643
4
UniProt:O00231 PSMD11
5
PSMD11 [cytosol]
(R-HSA-68790)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
0.643
5
UniProt:O00232 PSMD12
5
PSMD12 [cytosol]
(R-HSA-68792)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
0.643
5
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-386-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783067)
Ub-6-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783122)
0.609
11
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.592
4
UniProt:Q9Y5K5-3 UCHL5
0.556
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q9UNM6 PSMD13
5
PSMD13 [cytosol]
(R-HSA-68794)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
0.527
4
UniProt:Q5VYK3 ECM29
0.527
3
UniProt:A2A3N6 PIPSL
0.527
2
UniProt:Q5JXX7 TMM31
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q53HC0 CCD92
0.527
3
UniProt:O35593
5
PSMD14 [ficolin-1-rich granule lumen]
(R-MMU-6800419)
PSMD14 [extracellular region]
(R-MMU-6806511)
PSMD14 [secretory granule lumen]
(R-MMU-6800926)
PSMD14 [nucleoplasm]
(R-MMU-174329)
PSMD14 [cytosol]
(R-MMU-68722)
0.499
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
9
UniProt:P60896 SEM1
2
SEM1 [cytosol]
(R-HSA-8866674)
SEM1 [nucleoplasm]
(R-HSA-8866665)
0.462
3
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