Reactome | AP1B1 [lysosomal membrane]

AP1B1 [lysosomal membrane]

Stable Identifier

R-HSA-432699

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

AP-1 beta subunit

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q10567 AP1B1

Gene Names

AP1B1, ADTB1, BAM22, CLAPB2

Chain

chain:1-949

Reference Genes

BioGPS Gene:162 AP1B1

COSMIC (genes):AP1B1 AP1B1

CTD Gene:162 AP1B1

dbSNP Gene:162 AP1B1

ENSEMBL:ENSG00000100280 AP1B1

HGNC:554 AP1B1

KEGG Gene (Homo sapiens):162 AP1B1

Monarch:162 AP1B1

NCBI Gene:162 AP1B1

OMIM:600157 AP1B1

UCSC:Q10567 AP1B1

Reference Transcript

Other Identifiers

0006860707

11730427_a_at

11730428_a_at

162

16933591

205423_at

3956782

3956783

3956784

3956785

3956788

3956791

3956792

3956793

3956795

3956796

3956798

3956799

3956800

3956801

3956803

3956804

3956805

3956807

3956808

3956810

3956811

3956812

3956814

3956815

3956816

3956817

3956823

3956824

3956829

3956831

40745_at

8075217

A_23_P6398

A_33_P3317593

GE57637

GO:0000139

GO:0001822

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005794

GO:0005829

GO:0006810

GO:0006886

GO:0007368

GO:0007507

GO:0008150

GO:0015031

GO:0016020

GO:0016192

GO:0019886

GO:0019899

GO:0019901

GO:0030117

GO:0030131

GO:0030276

GO:0030659

GO:0030665

GO:0031410

GO:0032588

GO:0032991

GO:0043226

GO:0043231

GO:0044403

GO:0048856

GO:0050690

ILMN_1781983

ILMN_2387505

L13939_s_at

PH_hs_0016268

TC22000634.hg

g4501972_3p_at

Participant Of

hasComponent

AP-1 Complex [lysosomal membrane]

Other forms of this molecule

AP1B1 [cytosol]

AP1B1 [trans-Golgi network membrane]

AP1B1 [Golgi membrane]

AP1B1 [cytoplasmic vesicle membrane]

Inferred To

apb-1 [lysosomal membrane] (Caenorhabditis elegans)

ap1b1 [lysosomal membrane] (Danio rerio)

ap1b1 [lysosomal membrane] (Dictyostelium discoideum)

Ap1b1 [lysosomal membrane] (Mus musculus)

Ap1b1 [lysosomal membrane] (Rattus norvegicus)

AP-1-2beta [lysosomal membrane] (Drosophila melanogaster)

AP1B1 [lysosomal membrane] (Canis familiaris)

AP1B1 [lysosomal membrane] (Gallus gallus)

AP1B1 [lysosomal membrane] (Sus scrofa)

AP1B1 [lysosomal membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001159491.1, NP_663782.2, NP_001118.3

OpenTargets

ENSG00000100280

HPA

ENSG00000100280-AP1B1

GeneCards

Q10567

Ensembl

ENST00000357586, ENSG00000100280, ENSP00000386071, ENST00000402502, ENSP00000319361, ENSP00000400065, ENST00000415447, ENST00000405198, ENST00000432560, ENSP00000387612, ENSP00000384194, ENST00000317368, ENSP00000350199

PRO

Q10567

Orphanet

28822

PDB

4HMY, 6DFF, 6D83, 4P6Z, 6CM9, 6CRI, 6D84

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2