Reactome | COPG2 [transport vesicle]

COPG2 [transport vesicle]

Stable Identifier

R-HSA-6808753

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        tetrameric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPG1,2 [transport vesicle] (Homo sapiens)
        
        COPG2 [transport vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UBF2 COPG2

Gene Names

COPG2

Chain

chain:1-871

Reference Genes

BioGPS Gene:26958 COPG2

COSMIC (genes):COPG2 COPG2

CTD Gene:26958 COPG2

dbSNP Gene:26958 COPG2

ENSEMBL:ENSG00000158623 COPG2

HGNC:2237 COPG2

KEGG:hsa:26958 COPG2

Monarch:26958 COPG2

NCBI Gene:26958 COPG2

OMIM:604355 COPG2

UCSC:Q9UBF2 COPG2

Reference Transcript

Other Identifiers

11728705_at

11747220_a_at

17062906

223457_PM_at

223457_at

233569_PM_at

233569_at

26958

3072631

3072632

3072633

3072634

3072635

3072637

3072639

3072641

3072650

3072651

3072652

3072653

3072668

3072669

3072670

3072671

3072675

3072676

77933_at

8142945

A_23_P61280

GE80515

GO:0000139

GO:0005198

GO:0005737

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006890

GO:0006891

GO:0007018

GO:0009306

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030126

GO:0030133

GO:0030137

GO:0030426

GO:0030663

GO:0031090

GO:0031410

GO:0043226

GO:0072384

HMNXSV003012213

HMNXSV003019568

Hs.6421.1.A1_3p_at

Hs2.145223.1.S1_3p_s_at

ILMN_1809496

PH_hs_0013578

TC07003379.hg

g11094284_3p_at

Participates

as a member of

COPG1,2 [transport vesicle] (Homo sapiens)

Other forms of this molecule

COPG2 [endoplasmic reticulum membrane]

COPG2 [Golgi membrane]

COPG2 [cytosol]

Inferred To

SEC21 [transport vesicle] (Saccharomyces cerevisiae)

Copg2 [transport vesicle] (Mus musculus)

Copg2 [transport vesicle] (Rattus norvegicus)

copg-1 [transport vesicle] (Caenorhabditis elegans)

gammaCOP [transport vesicle] (Drosophila melanogaster)

copG [transport vesicle] (Dictyostelium discoideum)

copg2 [transport vesicle] (Danio rerio)

copg2 [transport vesicle] (Xenopus tropicalis)

sec21 [transport vesicle] (Schizosaccharomyces pombe)

COPG2 [transport vesicle] (Bos taurus)

COPG2 [transport vesicle] (Canis familiaris)

COPG2 [transport vesicle] (Gallus gallus)

COPG2 [transport vesicle] (Plasmodium falciparum)

COPG2 [transport vesicle] (Sus scrofa)

Cross References

ENSEMBL

ENST00000330992, ENSG00000158623, ENSP00000402346, ENST00000425248, ENSP00000331218

OpenTargets

ENSG00000158623

GeneCards

COPG2

HPA

ENSG00000158623-COPG2

PRO

Q9UBF2

Pharos - Targets

Q9UBF2

GlyGen

Q9UBF2

HMDB Protein

HMDBP08334

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	3
UniProt:P04233 CD74	13	CD74 [plasma membrane] (R-HSA-2130666) CD74 [lysosomal membrane] (R-HSA-2130320) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(81-104) [lysosomal lumen] (R-HSA-2213220)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7