Reactome | HSD17B4(1-736) [peroxisomal matrix]

HSD17B4(1-736) [peroxisomal matrix]

Stable Identifier

R-HSA-192322

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

Peroxisomal multifunctional enzyme type 2, hydroxysteroid (17-beta) dehydrogenase 4, HSD17B4, DHB4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P51659 HSD17B4

Gene Names

HSD17B4, EDH17B4, SDR8C1

Chain

chain:1-736, chain:1-311, chain:312-736

Reference Genes

BioGPS Gene:3295 HSD17B4

COSMIC (genes):HSD17B4 HSD17B4

CTD Gene:3295 HSD17B4

dbSNP Gene:3295 HSD17B4

ENSEMBL:ENSG00000133835 HSD17B4

HGNC:5213 HSD17B4

KEGG:hsa:3295 HSD17B4

Monarch:3295 HSD17B4

NCBI Gene:3295 HSD17B4

OMIM:601860 HSD17B4

UCSC:P51659 HSD17B4

Reference Transcript

Other Identifiers

11737761_a_at

11737762_x_at

11747333_a_at

1563696_PM_at

1563696_at

16988376

201413_PM_at

201413_at

2825734

2825735

2825736

2825738

2825739

2825742

2825743

2825744

2825745

2825746

2825747

2825748

2825749

2825750

2825751

2825752

2825753

2825754

2825755

2825756

2825757

2825758

2825760

2825763

2825765

2825766

2825769

2825770

2825771

2825772

2825773

2825774

2825775

2825776

2825777

2825778

2825779

2825782

2825783

2825784

2825795

2825797

2825814

2825815

2825816

3295

36626_at

8107532

A_14_P103618

A_14_P121460

A_23_P92954

GE60112

GE793093

GE84741

GO:0000038

GO:0001649

GO:0003824

GO:0003857

GO:0004300

GO:0004303

GO:0005777

GO:0005778

GO:0005782

GO:0005829

GO:0006629

GO:0006631

GO:0006635

GO:0006790

GO:0008209

GO:0008210

GO:0016020

GO:0016491

GO:0016829

GO:0016853

GO:0018812

GO:0022414

GO:0030154

GO:0033989

GO:0036111

GO:0036112

GO:0042803

GO:0043226

GO:0044594

GO:0048856

GO:0055086

GO:0060009

GO:0106386

GO:1901135

HMNXSV003020652

Hs2.356894.1.S1_3p_s_at

Hs2.434369.1.S1_3p_at

ILMN_1673795

PH_hs_0020322

PH_hs_0024007

PH_hs_0039622

TC05000567.hg

X87176_at

g4504504_3p_at

Participates

as an input of

TYSND1 cleaves HSD17B4 (Homo sapiens)

as a member of

Cargo proteins containing PTS1 [peroxisomal matrix] (Homo sapiens)

as a component of

HSD17B4 dimer [peroxisomal matrix] (Homo sapiens)

Other forms of this molecule

HSD17B4 [cytosol]

HSD17B4(1-311) [peroxisomal matrix]

HSD17B4(312-736) [peroxisomal matrix]

Inferred To

HSD17B4 [peroxisomal matrix] (Bos taurus)

HSD17B4 [peroxisomal matrix] (Canis familiaris)

HSD17B4 [peroxisomal matrix] (Gallus gallus)

maoc-1 [peroxisomal matrix] (Caenorhabditis elegans)

HSD17B4(1-736) [peroxisomal matrix] (Dictyostelium discoideum)

HSD17B4(1-736) [peroxisomal matrix] (Drosophila melanogaster)

HSD17B4(1-736) [peroxisomal matrix] (Mus musculus)

HSD17B4(1-736) [peroxisomal matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_001278956.1, NP_001186220.1, NP_001278957.1, NP_001186221.1, NP_000405.1

OpenTargets

ENSG00000133835

ENSEMBL

ENSP00000424613, ENSP00000411960, ENSP00000424940, ENST00000414835, ENST00000515320, ENST00000510025

ZINC - Substances

DHB4_HUMAN

ZINC target

P51659

PRO

P51659

GlyGen

P51659

PDB

1ZBQ, 6Z1W, 6Z1X, 8AF2, 1S9C, 1IKT, 8AF3

IntEnz

4.2.1.107

HPA

ENSG00000133835-HSD17B4

Pharos - Targets

P51659

Orphanet

HSD17B4

HMDB Protein

HMDBP00476

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9
UniProt:P08567 PLEK	2	PLEK [extracellular region] (R-HSA-350741) PLEK [cytosol] (R-HSA-350715)	0.462	2

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