Reactome | CTBP2 [nucleoplasm]

CTBP2 [nucleoplasm]

Stable Identifier

R-HSA-5333990

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by WNT in cancer (Homo sapiens)
    - Signaling by TCF7L2 mutants (Homo sapiens)
      - TFC7L2 mutants don't bind CTBP (Homo sapiens)
        
        CTBPs [nucleoplasm] (Homo sapiens)
        
        CTBP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P56545 CTBP2

Gene Names

CTBP2

Chain

chain:1-445

Reference Genes

BioGPS Gene:1488 CTBP2

COSMIC (genes):CTBP2 CTBP2

CTD Gene:1488 CTBP2

dbSNP Gene:1488 CTBP2

ENSEMBL:ENSG00000175029 CTBP2

HGNC:2495 CTBP2

KEGG Gene (Homo sapiens):1488 CTBP2

Monarch:1488 CTBP2

NCBI Gene:1488 CTBP2

OMIM:602619 CTBP2

UCSC:P56545 CTBP2

Reference Transcript

Other Identifiers

0003170333

0003990717

0006100358

11740001_x_at

11740002_a_at

11740085_x_at

11743316_x_at

11744671_x_at

11747782_x_at

11750265_x_at

1488

201218_at

201219_at

201220_x_at

210554_s_at

210835_s_at

2417438

2417463

2417469

2417471

2821712

2821716

2821718

3311410

3311412

3311414

3311416

3311418

3311419

3311420

3311421

3311422

3311423

3311424

3311427

3311428

3311429

3311431

3311432

3311433

3311434

3311436

3311441

3311442

3311445

3311446

3311447

3311459

3311460

3311461

3311462

3311463

3311464

3311465

3311466

3311467

3311468

3311469

3311470

3311471

3311475

3311476

3311496

3311507

3311514

3311515

3311517

3311518

3311519

3328050

3328056

40780_at

57955_s_at

7936904

8180351

A_23_P63897

A_24_P103922

A_33_P3318624

GE54139

GO:0000122

GO:0001226

GO:0003674

GO:0003682

GO:0003713

GO:0003714

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006810

GO:0007165

GO:0007267

GO:0008134

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0016032

GO:0016081

GO:0016192

GO:0016491

GO:0016616

GO:0017053

GO:0019079

GO:0019899

GO:0019901

GO:0030054

GO:0030154

GO:0032991

GO:0034330

GO:0034641

GO:0035563

GO:0042802

GO:0042974

GO:0043226

GO:0044403

GO:0044877

GO:0045202

GO:0045892

GO:0045944

GO:0048386

GO:0048790

GO:0050872

GO:0051287

GO:0055114

GO:0097470

GO:0098684

GO:0098831

GO:0098882

GO:0098978

GO:0098982

GO:0099523

GO:1990830

HMNXSV003043497

Hs.171391.0.S2_3p_at

Hs.171391.0.S2_3p_x_at

Hs.171391.0.S3_3p_at

ILMN_1691294

ILMN_3250209

PH_hs_0027927

TC10001732.hg

g12803334_3p_a_at

Participates

as a candidate of

CTBPs [nucleoplasm] (Homo sapiens)

Inferred To

CTBP2 [nucleoplasm] (Bos taurus)

CTBP2 [nucleoplasm] (Canis familiaris)

CTBP2 [nucleoplasm] (Gallus gallus)

CTBP2 [nucleoplasm] (Sus scrofa)

CtBP [nucleoplasm] (Drosophila melanogaster)

ctbp-1 [nucleoplasm] (Caenorhabditis elegans)

ctbp2a [nucleoplasm] (Danio rerio)

Ctbp2 [nucleoplasm] (Mus musculus)

Ctbp2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_005269618.1, XP_011537656.1, NP_001307942.1, XP_011537653.1, XP_005269621.1, XP_005269625.1, XP_005269628.1, NP_001277143.1, XP_006717705.1, NP_073713.2, XP_016871245.1, XP_011537657.1, NP_001307943.1, NP_001307941.1, XP_011537655.1, XP_005269624.1, XP_005269626.1, XP_005269629.1, XP_016871246.1, NP_001277144.1, NP_001077383.1, NP_001320.1, XP_011537651.1

OpenTargets

ENSG00000175029

GeneCards

P56545

HPA

ENSG00000175029-CTBP2

Ensembl

ENST00000337195, ENST00000531469, ENST00000494626, ENSP00000311825, ENSP00000357816, ENSG00000175029, ENST00000411419, ENSP00000338615, ENSP00000434630, ENSP00000436285, ENST00000334808, ENSP00000410474, ENST00000309035

PRO

P56545

Pharos - Targets

P56545

GlyGen

P56545

PDB

6WKW, 2OME, 4LCJ

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13363 CTBP1	3	SUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372) SUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.804	11
UniProt:Q8IVP5 FUNDC1	4	FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.556	3
UniProt:Q99708 RBBP8	4	p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138) p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399) Ac-K432,K526,K604-RBBP8 [nucleoplasm] (R-HSA-5685955)	0.547	2
UniProt:Q14526 HIC1	2	HIC1 [nucleoplasm] (R-HSA-4090364) SUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368)	0.508	2
UniProt:O75807 PPP1R15A	1	PPP1R15A [cytosol] (R-HSA-178231)	0.508	2