Reactome | CTBP2 [nucleoplasm]

CTBP2 [nucleoplasm]

Stable Identifier

R-HSA-5333990

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by WNT in cancer (Homo sapiens)
    - Signaling by TCF7L2 mutants (Homo sapiens)
      - TFC7L2 mutants don't bind CTBP (Homo sapiens)
        
        CTBPs [nucleoplasm] (Homo sapiens)
        
        CTBP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P56545 CTBP2

Gene Names

CTBP2

Chain

chain:1-445

Reference Genes

BioGPS Gene:1488 CTBP2

COSMIC (genes):CTBP2 CTBP2

CTD Gene:1488 CTBP2

dbSNP Gene:1488 CTBP2

ENSEMBL:ENSG00000175029 CTBP2

HGNC:2495 CTBP2

KEGG:hsa:1488 CTBP2

Monarch:1488 CTBP2

NCBI Gene:1488 CTBP2

OMIM:602619 CTBP2

UCSC:P56545 CTBP2

Reference Transcript

Participates

as a candidate of

CTBPs [nucleoplasm] (Homo sapiens)

Inferred To

CTBP2 [nucleoplasm] (Bos taurus)

CTBP2 [nucleoplasm] (Caenorhabditis elegans)

CTBP2 [nucleoplasm] (Canis familiaris)

CTBP2 [nucleoplasm] (Drosophila melanogaster)

CTBP2 [nucleoplasm] (Gallus gallus)

CTBP2 [nucleoplasm] (Mus musculus)

CTBP2 [nucleoplasm] (Rattus norvegicus)

CTBP2 [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000175029

ENSEMBL

ENST00000531469, ENST00000411419, ENSP00000311825, ENSP00000410474, ENSP00000434630, ENSP00000436285, ENSP00000357816, ENST00000334808, ENSG00000175029, ENST00000337195, ENSP00000338615, ENST00000494626, ENST00000309035

HPA

ENSG00000175029-CTBP2

GeneCards

CTBP2

PRO

P56545

Pharos - Targets

P56545

GlyGen

P56545

PDB

2OME, 8ATI, 6WKW, 4LCJ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.918	17
UniProt:O75362 ZNF217	1	ZNF217 [nucleoplasm] (R-HSA-9011738)	0.69	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.556	3
UniProt:Q99708 RBBP8	4	p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138) Ac-K-RBBP8 [nucleoplasm] (R-HSA-5685955) RBBP8 [nucleoplasm] (R-HSA-912399) p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083)	0.547	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.527	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	2
UniProt:O75807 PPP1R15A	1	PPP1R15A [cytosol] (R-HSA-178231)	0.508	2
UniProt:Q14526 HIC1	2	monoSUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368) HIC1 [nucleoplasm] (R-HSA-4090364)	0.508	2

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