Reactome | CLIP1 [cytosol]

CLIP1 [cytosol]

Stable Identifier

R-HSA-377732

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Clip170, CLIP-170

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CLIP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30622 CLIP1

Gene Names

CLIP1, CYLN1, RSN

Chain

chain:1-1438

Reference Genes

BioGPS Gene:6249 CLIP1

COSMIC (genes):CLIP1 CLIP1

CTD Gene:6249 CLIP1

dbSNP Gene:6249 CLIP1

ENSEMBL:ENSG00000130779 CLIP1

ENSEMBL:ENSG00000130779.22 CLIP1

HGNC:10461 CLIP1

KEGG Gene (Homo sapiens):6249 CLIP1

Monarch:6249 CLIP1

NCBI Gene:6249 CLIP1

OMIM:179838 CLIP1

UCSC:P30622 CLIP1

Reference Transcript

Other Identifiers

11740471_s_at

11740472_a_at

11740473_a_at

11743785_x_at

1558924_PM_s_at

1558924_s_at

16771680

201975_PM_at

201975_at

210716_PM_s_at

210716_s_at

2527359

34350_at

3475588

3475589

3475590

3475591

3475595

3475596

3475597

3475603

3475611

3475614

3475616

3475622

3475623

3475624

3475625

3475627

3475628

3475631

3475632

3475635

3475638

3475641

3475642

3475644

3475649

3475650

3475653

3475656

3475658

3475659

3475673

6249

75192_at

76751_at

7967255

A_23_P25003

A_24_P306425

GE59911

GO:0000278

GO:0000776

GO:0001578

GO:0001726

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005768

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005882

GO:0005938

GO:0007010

GO:0008017

GO:0008092

GO:0008270

GO:0015630

GO:0015631

GO:0016020

GO:0030659

GO:0031116

GO:0031122

GO:0031410

GO:0035371

GO:0042802

GO:0042995

GO:0043226

GO:0044354

GO:0046872

GO:0051010

GO:0065003

HMNXSV003039292

Hs2.432908.1.A1_3p_s_at

ILMN_1684038

ILMN_1723058

ILMN_2404085

PH_hs_0030090

TC12002073.hg

TC12003131.hg

X64838_at

g180621_3p_a_at

g4506750_3p_at

Participates

as a component of

as an input of

IQGAP1 binds CLIP1 and microtubules (Homo sapiens)

Inferred To

alp11 [cytosol] (Schizosaccharomyces pombe)

tbcb [cytosol] (Dictyostelium discoideum)

clip1 [cytosol] (Xenopus tropicalis)

Clip1 [cytosol] (Mus musculus)

Clip1 [cytosol] (Rattus norvegicus)

CLIP1 [cytosol] (Bos taurus)

CLIP1 [cytosol] (Canis familiaris)

CLIP1 [cytosol] (Danio rerio)

CLIP1 [cytosol] (Gallus gallus)

CLIP1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002947.1, NP_001234926.1, XP_016875275.1, NP_937883.1, XP_016875279.1

OpenTargets

ENSG00000130779

HPA

ENSG00000130779-CLIP1

GeneCards

P30622

Ensembl

ENST00000537178, ENST00000358808, ENST00000302528, ENSP00000479322, ENSP00000303585, ENSG00000130779, ENSP00000351665, ENST00000620786, ENSP00000445531

PRO

P30622

Pharos - Targets

P30622

Orphanet

22959

PDB

2CP6, 3RDV, 2E4H, 2E3H, 2HQH, 2QK0, 2CP5, 3E2U, 2E3I

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.672	3
UniProt:P68366 TUBA4A	9	AcK-TUBA4A [cytosol] (R-HSA-5618318) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) TUBA4A folding intermediate [cytosol] (R-HSA-392800) TUBA4A unfolded [cytosol] (R-HSA-392771) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) TUBA4A [extracellular region] (R-HSA-350734) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [cytosol] (R-HSA-191694)	0.618	3
UniProt:Q04864-2 REL			0.556	3
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.547	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4

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