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PLEKHG3 [cytosol]
Stable Identifier
R-HSA-9679580
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Pleckstrin homology domain-containing family G member 3, PH domain-containing family G member 3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG binds effectors at the plasma membrane (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
RHOQ GTPase cycle (Homo sapiens)
RHOQ binds effectors at the plasma membrane (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
PLEKHG3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:A1L390 PLEKHG3
Gene Names
PLEKHG3, KIAA0599
Chain
chain:1-1219
Reference Genes
BioGPS Gene:26030 PLEKHG3
COSMIC (genes):PLEKHG3 PLEKHG3
CTD Gene:26030 PLEKHG3
dbSNP Gene:26030 PLEKHG3
ENSEMBL:ENSG00000126822 PLEKHG3
HGNC:20364 PLEKHG3
KEGG:hsa:26030 PLEKHG3
Monarch:26030 PLEKHG3
NCBI Gene:26030 PLEKHG3
OMIM:617940 PLEKHG3
UCSC:A1L390 PLEKHG3
Reference Transcript
RefSeq:XM_017021157.1 PLEKHG3
RefSeq:NM_001308147.1 PLEKHG3
Other Identifiers
11748409_a_at
16785410
212821_PM_at
212821_at
212823_PM_s_at
212823_s_at
229952_PM_at
229952_at
26030
3540215
3540216
3540228
3540229
3540230
3540231
3540234
3540235
3540236
3540237
3540238
3540239
3540240
3540241
3540242
3540243
3540244
3540245
3540246
3540256
3540257
3540258
3540259
3540260
3540264
3540265
3540266
3540267
3540268
3540269
3540270
3540271
3540272
3540273
3540274
3540275
3540276
3540277
3540278
3540279
3540280
3540292
3540293
40959_at
7975095
A_14_P103520
A_14_P128220
A_23_P76901
A_32_P311737
A_33_P3304212
GE79262
GO:0003779
GO:0005085
GO:0005737
GO:0005829
GO:0005856
GO:0008092
GO:0030334
GO:0031267
GO:0043226
GO:0051056
GO:0098772
GO:2000114
HMNXSV003052057
Hs.198037.0.A1_3p_a_at
Hs.198037.0.A2_3p_at
Hs.198037.0.A2_3p_x_at
Hs.47431.2.A1_3p_at
ILMN_1780671
PH_hs_0037366
TC14000393.hg
TC14001731.hg
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
as a member of
CDC42 GEFs [cytosol] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
Inferred To
PLEKHG3 [cytosol]
(Bos taurus)
PLEKHG3 [cytosol]
(Canis familiaris)
PLEKHG3 [cytosol]
(Sus scrofa)
uig-1 [cytosol]
(Caenorhabditis elegans)
Plekhg3 [cytosol]
(Mus musculus)
Plekhg3 [cytosol]
(Rattus norvegicus)
GEFmeso [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000394691
,
ENSP00000378183
,
ENSG00000126822
,
ENST00000247226
,
ENSP00000247226
OpenTargets
ENSG00000126822
GeneCards
PLEKHG3
HPA
ENSG00000126822-PLEKHG3
PRO
A1L390
Pharos - Targets
A1L390
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
10
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