Reactome | DDX1 [nucleoplasm]

DDX1 [nucleoplasm]

Stable Identifier

R-HSA-5696771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ATP-dependent RNA helicase DDX1 ecNumber3.6.4.13/ecNumber, DDX1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92499 DDX1

Gene Names

DDX1

Chain

chain:1-740

Reference Genes

BioGPS Gene:1653 DDX1

COSMIC (genes):DDX1 DDX1

CTD Gene:1653 DDX1

dbSNP Gene:1653 DDX1

ENSEMBL:ENSG00000079785 DDX1

ENSEMBL:ENSG00000079785.16 DDX1

HGNC:2734 DDX1

KEGG Gene (Homo sapiens):1653 DDX1

Monarch:1653 DDX1

NCBI Gene:1653 DDX1

OMIM:601257 DDX1

UCSC:Q92499 DDX1

Reference Transcript

RefSeq:NM_004939.2 DDX1

Other Identifiers

11743035_a_at

1653

16877353

201241_PM_at

201241_at

2470655

2470656

2470657

2470659

2470660

2470661

2470663

2470665

2470666

2470667

2470668

2470669

2470670

2470671

2470673

2470675

2470676

2470677

2470678

2470679

2470683

2470686

2470688

2470691

2470693

2470695

2470697

2470700

2470701

37663_at

8040386

A_23_P108554

GE59972

GO:0000166

GO:0000245

GO:0002376

GO:0002735

GO:0003676

GO:0003677

GO:0003682

GO:0003712

GO:0003723

GO:0003724

GO:0003725

GO:0003824

GO:0004386

GO:0004518

GO:0004527

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006281

GO:0006302

GO:0006351

GO:0006388

GO:0006397

GO:0006399

GO:0006446

GO:0008033

GO:0008143

GO:0009615

GO:0010494

GO:0016020

GO:0016071

GO:0016787

GO:0016887

GO:0023052

GO:0032508

GO:0033677

GO:0043123

GO:0043226

GO:0043330

GO:0045087

GO:0051607

GO:0065003

GO:0071920

GO:0072669

GO:0090305

GO:0098542

GO:0140097

GO:0140098

GO:0140110

GO:0140657

GO:1903608

GO:1990904

HMNXSV003045931

ILMN_2182750

PH_hs_0025796

TC02000089.hg

X70649_at

g4826685_3p_at

Participates

as a component of

tRNA ligase complex [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_004930.1

OpenTargets

ENSG00000079785

IntEnz

3.6.4.13

GeneCards

Q92499

HPA

ENSG00000079785-DDX1

Ensembl

ENSP00000370745, ENSP00000413767, ENSG00000079785, ENST00000677302, ENST00000434671, ENST00000233084, ENSP00000504080, ENSP00000233084, ENST00000381341

PRO

Q92499

Pharos - Targets

Q92499

Orphanet

24460

PDB

4XW3

HMDB Protein

HMDBP11663

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.602	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7

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